Study on the synthesis technology of anticancer drug Gilteritinib fumarate

Based on the reported routes, a convergent eight-step approach to Gilteritinib fumarate was designed, which is suitable for industrial implementation. The first key intermediate, 3,5-dichloro-6-ethylpyrazine-2-carboxamide ( 6 ), was obtained from 2,6-dichloropyrazine in 49.3% yield by two subsequent...

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Veröffentlicht in:	Russian chemical bulletin 2023-08, Vol.72 (8), p.1921-1928
Hauptverfasser:	Xu, Huashen, Chen, Lu, Chen, Yuanguang, Fu, Yang, Xu, Feng, Chen, Guoliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Chemistry and Materials Science Chemistry/Food Science Full Articles Inorganic Chemistry Nitrobenzene Organic Chemistry Quebrachitol
Online-Zugang:	Volltext
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