Assessment of the applicability of methods and tools in process systems engineering for fermentation processes

Fermentation is the main process for converting substrates into bioproducts such as ethanol, bioplastics, and different foods and drinks. However, there are numerous challenges associated with the fermentation process in bioreactors and many of them can be solved using simulations based on process s...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Biofuels, bioproducts and biorefining bioproducts and biorefining, 2023-09, Vol.17 (5), p.1121-1155
Hauptverfasser: Brito Rodrigues de Jesus, Alexandre, Carvalho Miranda, Júlio Cesar
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1155
container_issue 5
container_start_page 1121
container_title Biofuels, bioproducts and biorefining
container_volume 17
creator Brito Rodrigues de Jesus, Alexandre
Carvalho Miranda, Júlio Cesar
description Fermentation is the main process for converting substrates into bioproducts such as ethanol, bioplastics, and different foods and drinks. However, there are numerous challenges associated with the fermentation process in bioreactors and many of them can be solved using simulations based on process systems engineering (PSE). This study's objective is the design and assessment of the applicability of simulations of three fermentation processes (alcoholic, lactic, and propanoic) through their kinetic parameters, using the commercial process system engineering platform Aspen Plus, integrated with a chemical kinetics subroutine made as a Fortran User Model for calculating the process balances. The simulations of fermentation models in Aspen Plus were consistent, considering the experimental models available in the literature. In most cases, the residual standard deviation (RSD) (%) obtained was below 10%, which is acceptable for biotechnological processes. Some cases did not represent the literature models due to the limitations of the simulator (thermodynamics and components), linked with the complexity of the model. The applicability of these models within a commercial simulator, although limited, is therefore valid for the design, analysis, and optimization of complex reactional systems, such as fermentation, which implies quick technological advances, especially regarding bioprocesses. © 2023 Society of Industrial Chemistry and John Wiley & Sons Ltd.
doi_str_mv 10.1002/bbb.2520
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2859550424</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2859550424</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2880-dc6c582b7db789ac85071f0eb6748f0bddfc5cf8415f7334ca4f9a5690baa7e53</originalsourceid><addsrcrecordid>eNp1kE1LAzEURYMoWKvgTwi4cTM1ySTzsWyLX1Bwo-AuJJmkTZlJxiRF5t87Y6U7V-_xOO9eOADcYrTACJEHKeWCMILOwAzXOckwyvH5aaefl-Aqxj1CrGCUzYBbxqhj7LRL0BuYdhqKvm-tEtK2Ng3TsdNp55sIhWtg8r6N0DrYB6_GRxiHmHQXoXZb67QO1m2h8QEaHaZQkaw_wTpegwsj2qhv_uYcfDw9vq9fss3b8-t6uckUqSqUNapQrCKybGRZ1UJVDJXYIC2LklYGyaYxiilTUcxMmedUCWpqwYoaSSFKzfI5uDvmjs1fBx0T3_tDcGMlJxWrGUOU0JG6P1Iq-BiDNrwPthNh4BjxySYfbfLJ5ohmR_Tbtnr4l-Or1eqX_wH1RHg-</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2859550424</pqid></control><display><type>article</type><title>Assessment of the applicability of methods and tools in process systems engineering for fermentation processes</title><source>Wiley Online Library All Journals</source><creator>Brito Rodrigues de Jesus, Alexandre ; Carvalho Miranda, Júlio Cesar</creator><creatorcontrib>Brito Rodrigues de Jesus, Alexandre ; Carvalho Miranda, Júlio Cesar</creatorcontrib><description>Fermentation is the main process for converting substrates into bioproducts such as ethanol, bioplastics, and different foods and drinks. However, there are numerous challenges associated with the fermentation process in bioreactors and many of them can be solved using simulations based on process systems engineering (PSE). This study's objective is the design and assessment of the applicability of simulations of three fermentation processes (alcoholic, lactic, and propanoic) through their kinetic parameters, using the commercial process system engineering platform Aspen Plus, integrated with a chemical kinetics subroutine made as a Fortran User Model for calculating the process balances. The simulations of fermentation models in Aspen Plus were consistent, considering the experimental models available in the literature. In most cases, the residual standard deviation (RSD) (%) obtained was below 10%, which is acceptable for biotechnological processes. Some cases did not represent the literature models due to the limitations of the simulator (thermodynamics and components), linked with the complexity of the model. The applicability of these models within a commercial simulator, although limited, is therefore valid for the design, analysis, and optimization of complex reactional systems, such as fermentation, which implies quick technological advances, especially regarding bioprocesses. © 2023 Society of Industrial Chemistry and John Wiley &amp; Sons Ltd.</description><identifier>ISSN: 1932-104X</identifier><identifier>EISSN: 1932-1031</identifier><identifier>DOI: 10.1002/bbb.2520</identifier><language>eng</language><publisher>Chichester, UK: John Wiley &amp; Sons, Ltd</publisher><subject>Aspen Plus ; Biologically grown products ; Bioplastics ; Bioreactors ; Chemical kinetics ; Complexity ; Design ; Design optimization ; Ethanol ; Fermentation ; Kinetics ; Reaction kinetics ; Simulation ; Simulators ; Substrates ; Systems engineering ; transient state ; user sub‐routine</subject><ispartof>Biofuels, bioproducts and biorefining, 2023-09, Vol.17 (5), p.1121-1155</ispartof><rights>2023 Society of Industrial Chemistry and John Wiley &amp; Sons Ltd.</rights><rights>2023 Society of Chemical Industry and John Wiley &amp; Sons, Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2880-dc6c582b7db789ac85071f0eb6748f0bddfc5cf8415f7334ca4f9a5690baa7e53</cites><orcidid>0000-0001-7545-5948 ; 0000-0002-2925-419X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbbb.2520$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbbb.2520$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids></links><search><creatorcontrib>Brito Rodrigues de Jesus, Alexandre</creatorcontrib><creatorcontrib>Carvalho Miranda, Júlio Cesar</creatorcontrib><title>Assessment of the applicability of methods and tools in process systems engineering for fermentation processes</title><title>Biofuels, bioproducts and biorefining</title><description>Fermentation is the main process for converting substrates into bioproducts such as ethanol, bioplastics, and different foods and drinks. However, there are numerous challenges associated with the fermentation process in bioreactors and many of them can be solved using simulations based on process systems engineering (PSE). This study's objective is the design and assessment of the applicability of simulations of three fermentation processes (alcoholic, lactic, and propanoic) through their kinetic parameters, using the commercial process system engineering platform Aspen Plus, integrated with a chemical kinetics subroutine made as a Fortran User Model for calculating the process balances. The simulations of fermentation models in Aspen Plus were consistent, considering the experimental models available in the literature. In most cases, the residual standard deviation (RSD) (%) obtained was below 10%, which is acceptable for biotechnological processes. Some cases did not represent the literature models due to the limitations of the simulator (thermodynamics and components), linked with the complexity of the model. The applicability of these models within a commercial simulator, although limited, is therefore valid for the design, analysis, and optimization of complex reactional systems, such as fermentation, which implies quick technological advances, especially regarding bioprocesses. © 2023 Society of Industrial Chemistry and John Wiley &amp; Sons Ltd.</description><subject>Aspen Plus</subject><subject>Biologically grown products</subject><subject>Bioplastics</subject><subject>Bioreactors</subject><subject>Chemical kinetics</subject><subject>Complexity</subject><subject>Design</subject><subject>Design optimization</subject><subject>Ethanol</subject><subject>Fermentation</subject><subject>Kinetics</subject><subject>Reaction kinetics</subject><subject>Simulation</subject><subject>Simulators</subject><subject>Substrates</subject><subject>Systems engineering</subject><subject>transient state</subject><subject>user sub‐routine</subject><issn>1932-104X</issn><issn>1932-1031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kE1LAzEURYMoWKvgTwi4cTM1ySTzsWyLX1Bwo-AuJJmkTZlJxiRF5t87Y6U7V-_xOO9eOADcYrTACJEHKeWCMILOwAzXOckwyvH5aaefl-Aqxj1CrGCUzYBbxqhj7LRL0BuYdhqKvm-tEtK2Ng3TsdNp55sIhWtg8r6N0DrYB6_GRxiHmHQXoXZb67QO1m2h8QEaHaZQkaw_wTpegwsj2qhv_uYcfDw9vq9fss3b8-t6uckUqSqUNapQrCKybGRZ1UJVDJXYIC2LklYGyaYxiilTUcxMmedUCWpqwYoaSSFKzfI5uDvmjs1fBx0T3_tDcGMlJxWrGUOU0JG6P1Iq-BiDNrwPthNh4BjxySYfbfLJ5ohmR_Tbtnr4l-Or1eqX_wH1RHg-</recordid><startdate>202309</startdate><enddate>202309</enddate><creator>Brito Rodrigues de Jesus, Alexandre</creator><creator>Carvalho Miranda, Júlio Cesar</creator><general>John Wiley &amp; Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7ST</scope><scope>7TA</scope><scope>7TB</scope><scope>7TN</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H95</scope><scope>H98</scope><scope>H99</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L.F</scope><scope>L.G</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>SOI</scope><orcidid>https://orcid.org/0000-0001-7545-5948</orcidid><orcidid>https://orcid.org/0000-0002-2925-419X</orcidid></search><sort><creationdate>202309</creationdate><title>Assessment of the applicability of methods and tools in process systems engineering for fermentation processes</title><author>Brito Rodrigues de Jesus, Alexandre ; Carvalho Miranda, Júlio Cesar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2880-dc6c582b7db789ac85071f0eb6748f0bddfc5cf8415f7334ca4f9a5690baa7e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aspen Plus</topic><topic>Biologically grown products</topic><topic>Bioplastics</topic><topic>Bioreactors</topic><topic>Chemical kinetics</topic><topic>Complexity</topic><topic>Design</topic><topic>Design optimization</topic><topic>Ethanol</topic><topic>Fermentation</topic><topic>Kinetics</topic><topic>Reaction kinetics</topic><topic>Simulation</topic><topic>Simulators</topic><topic>Substrates</topic><topic>Systems engineering</topic><topic>transient state</topic><topic>user sub‐routine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brito Rodrigues de Jesus, Alexandre</creatorcontrib><creatorcontrib>Carvalho Miranda, Júlio Cesar</creatorcontrib><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics &amp; Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Environment Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical &amp; Transportation Engineering Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>ANTE: Abstracts in New Technology &amp; Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Aquatic Science &amp; Fisheries Abstracts (ASFA) 1: Biological Sciences &amp; Living Resources</collection><collection>Aquatic Science &amp; Fisheries Abstracts (ASFA) Aquaculture Abstracts</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Aquatic Science &amp; Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science &amp; Fisheries Abstracts (ASFA) Professional</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts – Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Biofuels, bioproducts and biorefining</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brito Rodrigues de Jesus, Alexandre</au><au>Carvalho Miranda, Júlio Cesar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of the applicability of methods and tools in process systems engineering for fermentation processes</atitle><jtitle>Biofuels, bioproducts and biorefining</jtitle><date>2023-09</date><risdate>2023</risdate><volume>17</volume><issue>5</issue><spage>1121</spage><epage>1155</epage><pages>1121-1155</pages><issn>1932-104X</issn><eissn>1932-1031</eissn><abstract>Fermentation is the main process for converting substrates into bioproducts such as ethanol, bioplastics, and different foods and drinks. However, there are numerous challenges associated with the fermentation process in bioreactors and many of them can be solved using simulations based on process systems engineering (PSE). This study's objective is the design and assessment of the applicability of simulations of three fermentation processes (alcoholic, lactic, and propanoic) through their kinetic parameters, using the commercial process system engineering platform Aspen Plus, integrated with a chemical kinetics subroutine made as a Fortran User Model for calculating the process balances. The simulations of fermentation models in Aspen Plus were consistent, considering the experimental models available in the literature. In most cases, the residual standard deviation (RSD) (%) obtained was below 10%, which is acceptable for biotechnological processes. Some cases did not represent the literature models due to the limitations of the simulator (thermodynamics and components), linked with the complexity of the model. The applicability of these models within a commercial simulator, although limited, is therefore valid for the design, analysis, and optimization of complex reactional systems, such as fermentation, which implies quick technological advances, especially regarding bioprocesses. © 2023 Society of Industrial Chemistry and John Wiley &amp; Sons Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley &amp; Sons, Ltd</pub><doi>10.1002/bbb.2520</doi><tpages>35</tpages><orcidid>https://orcid.org/0000-0001-7545-5948</orcidid><orcidid>https://orcid.org/0000-0002-2925-419X</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-104X
ispartof Biofuels, bioproducts and biorefining, 2023-09, Vol.17 (5), p.1121-1155
issn 1932-104X
1932-1031
language eng
recordid cdi_proquest_journals_2859550424
source Wiley Online Library All Journals
subjects Aspen Plus
Biologically grown products
Bioplastics
Bioreactors
Chemical kinetics
Complexity
Design
Design optimization
Ethanol
Fermentation
Kinetics
Reaction kinetics
Simulation
Simulators
Substrates
Systems engineering
transient state
user sub‐routine
title Assessment of the applicability of methods and tools in process systems engineering for fermentation processes
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T14%3A52%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Assessment%20of%20the%20applicability%20of%20methods%20and%20tools%20in%20process%20systems%20engineering%20for%20fermentation%20processes&rft.jtitle=Biofuels,%20bioproducts%20and%20biorefining&rft.au=Brito%20Rodrigues%20de%20Jesus,%20Alexandre&rft.date=2023-09&rft.volume=17&rft.issue=5&rft.spage=1121&rft.epage=1155&rft.pages=1121-1155&rft.issn=1932-104X&rft.eissn=1932-1031&rft_id=info:doi/10.1002/bbb.2520&rft_dat=%3Cproquest_cross%3E2859550424%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2859550424&rft_id=info:pmid/&rfr_iscdi=true