Assessment of the applicability of methods and tools in process systems engineering for fermentation processes
Fermentation is the main process for converting substrates into bioproducts such as ethanol, bioplastics, and different foods and drinks. However, there are numerous challenges associated with the fermentation process in bioreactors and many of them can be solved using simulations based on process s...
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Veröffentlicht in: | Biofuels, bioproducts and biorefining bioproducts and biorefining, 2023-09, Vol.17 (5), p.1121-1155 |
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description | Fermentation is the main process for converting substrates into bioproducts such as ethanol, bioplastics, and different foods and drinks. However, there are numerous challenges associated with the fermentation process in bioreactors and many of them can be solved using simulations based on process systems engineering (PSE). This study's objective is the design and assessment of the applicability of simulations of three fermentation processes (alcoholic, lactic, and propanoic) through their kinetic parameters, using the commercial process system engineering platform Aspen Plus, integrated with a chemical kinetics subroutine made as a Fortran User Model for calculating the process balances. The simulations of fermentation models in Aspen Plus were consistent, considering the experimental models available in the literature. In most cases, the residual standard deviation (RSD) (%) obtained was below 10%, which is acceptable for biotechnological processes. Some cases did not represent the literature models due to the limitations of the simulator (thermodynamics and components), linked with the complexity of the model. The applicability of these models within a commercial simulator, although limited, is therefore valid for the design, analysis, and optimization of complex reactional systems, such as fermentation, which implies quick technological advances, especially regarding bioprocesses. © 2023 Society of Industrial Chemistry and John Wiley & Sons Ltd. |
doi_str_mv | 10.1002/bbb.2520 |
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subjects | Aspen Plus Biologically grown products Bioplastics Bioreactors Chemical kinetics Complexity Design Design optimization Ethanol Fermentation Kinetics Reaction kinetics Simulation Simulators Substrates Systems engineering transient state user sub‐routine |
title | Assessment of the applicability of methods and tools in process systems engineering for fermentation processes |
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