Dietary protein restriction increases plasma soluble leptin receptor levels and suppresses the appetite-reducing effect of administered leptin

Background and objectives: Leptin, a hormone secreted by the adipose tissue, suppresses appetite and regulates body fat mass. We found that the liver leptin receptor (Ob-R) mRNA and plasma soluble Ob-R (sOb-R) levels increased in mice fed a low-protein diet. In this study, we investigated the physio...

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