1173-P: Maternally Supplemented PQQ Targets Ceramide Metabolism in Offspring to Blunt Developmental Programming of NAFLD

Maternal obesity is a key risk factor for pediatric nonalcoholic fatty liver disease (NAFLD). Using a mouse model of Western-style diet (WD)-induced maternal obesity, we studied effects of supplementing dams with pyrroloquinoline quinone (PQQ; a potent dietary antioxidant) during gestation and lacta...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2023-06, Vol.72 (Supplement_1), p.1
Hauptverfasser:	MANDALA, ASHOK, TEAGUE, APRIL M., JANSSEN, RACHEL, PATIL, NIKHIL, JOSHI, ADITYA D., FRIEDMAN, JACOB E., JONSCHER, KAREN R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Body weight gain Ceramide Chromatin Cytochrome P450 Desaturase Fatty acids Fatty liver Fibrosis Immune response Lactation Lipid metabolism Liver diseases Long-term effects Metabolism Neonates Obesity Offspring Pediatrics Pyrroloquinoline quinone Risk factors Signal transduction Sphingolipids Steatosis Triglycerides
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