231-OR: Reduced NKX2-2 Expression Enhances Insulin Secretion by Primary Human ß-Cells

Pancreatic islet endocrine cell phenotype and function are tightly regulated by transcription factor (TF) regulatory networks. In a mouse model of pancreas organogenesis, the key islet-enriched TF NKX2.2 governs both β and α cell specification. Further, loss of NKX2.2 in adult mouse β cells results...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2023-06, Vol.72 (Supplement_1), p.1
Hauptverfasser:	PETTWAY, YASMINYE D., WALKER, JOHN, DAI, CHUNHUA, ARAMANDLA, RADHIKA, HOPKIRK, ALEXANDER L., REIHSMANN, CONRAD, DAVIS, COREY, JENKINS, REGINA, SUSSEL, LORI, PARKER, STEPHEN, POWERS, ALVIN C., BRISSOVA, MARCELA
Format:	Artikel
Sprache:	eng
Schlagworte:	Beta cells CRISPR Diabetes mellitus Glucose Glucose tolerance Immunofluorescence Insulin Insulin secretion Intolerance Islet cells Nkx2.2 protein Organogenesis Phenotypes
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