1540-P: Diazoxide (DZ) May Lower Endogenous Glucose Production (EGP) via Mitochondrial ATP-Sensitive K+ (mt KATP) Channels

Rodent and human studies suggest that ventromedial hypothalamus (VMH) KATP channels suppress EGP. The VMH possesses glucose-sensing neurons that are either excited (GE) or inhibited (GI) by glucose. Since administration of the KATP channel activator DZ reduces EGP in rodents and humans, we examined...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2023-06, Vol.72 (Supplement_1), p.1
Hauptverfasser:	VAIL, GWYNDOLIN, PATEL, VISHWENDRA, SARKAR, PALLABI, ZHANG, KEHAO, HAWKINS, MEREDITH, ROUTH, VANESSA H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemoreception Glucose Hypothalamus (ventromedial) Membrane potential Neurons
Online-Zugang:	Volltext
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