421-P: Methylglyoxal-Derived Advanced Glycation End Products Are Prognostic Biomarkers for Diabetic Complications and Drivers of Endothelial Dysfunction

Diabetic kidney disease (DKD) affects over 30% of individuals with T1D, significantly increasing mortality risk in this population. Canonical tools to predict DKD such as glomerular filtration rate (GFR) or albumin excretion rate (AER) alone may not be sufficient to predict disease risk, as they oft...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2023-06, Vol.72 (Supplement_1), p.1
Hauptverfasser:	LAI, SEIGMUND, LOPEZ GONZALEZ, EDWIN D.J., SHUCK, SARAH
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced glycosylation end products Biomarkers Diabetes Diabetes mellitus Endothelial cells Gene expression Glomerular filtration rate Glycolysis Glycosylation Inflammation Kidney diseases Lipid metabolism Macromolecules Mass spectroscopy Medical prognosis Metabolic flux NF-κB protein Oxidative stress Protein turnover Pyruvaldehyde Umbilical vein
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