83-OR: Defining the Transcriptome and Epitranscriptome of the ß-Cell Compensation to Insulin Resistance

Type 2 diabetes (T2D) is characterized by decreased functional β-cell mass and poor compensation to insulin resistance. Thus, understanding of the mechanism(s) responsible for the physiological adaptation of β-cells to states of high metabolic demand is desirable. We aimed to dissect the transcripto...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2023-06, Vol.72 (Supplement_1), p.1
Hauptverfasser:	DE JESUS, DARIO F., ZHANG, ZIJIE, WEI, JIANGBO, BROWN, NATALIE K., HU, JIANG, KAHRAMAN, SEVIM, DIRICE, ERCUMENT, KULKARNI, ROHIT
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Animal models Beta cells Bioinformatics Cell proliferation Chromatin Diabetes mellitus (non-insulin dependent) Diet Extracellular matrix High fat diet Insulin resistance Insulin secretion N6-methyladenosine Secretion Transcriptomes Transcriptomics
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