1413-P: Associations of Age at Menarche with Biomarkers of Inflammation and Glucose Metabolism in U.S. Adult Women—NHANES 1999–2018

Background: Early age at menarche (AAM) is a risk factor for type 2 diabetes later in life, but the pathways involved remain unknown. We examined the associations of AAM with C-reactive protein, fasting glucose, and fasting insulin among U.S. adult women free of diabetes in adulthood. Methods: Using the National Health and Nutrition Examination Survey (NHANES) 1999-2018, 19,228 women over 20 years old, free of cancer and diabetes were included in our cross-sectional analysis. AAM was self-reported age of first menstruation. Multiple linear regression was performed on biomarkers measured in adulthood. Results: The median age was 44 years (IQR, 33-62). Age-adjusted least-square means for AAM categories ≤10, 11, 12, 13, 14, and ≥15 years were 1.42, 1.08, 1.05, 0.80, 0.84, and 0.91 mg/L for C-reactive protein (P-trend=0.006); 84.85, 69.19, 68.11, 67.27, 64.42, and 60.69 pmol/L for fasting glucose (P-trend