High-cholesterol diet in combination with hydroxypropyl-beta-cyclodextrin induces NASH-like disorders in the liver of rats

Non-alcoholic fatty liver disease (NAFLD) is a general term for fatty liver disease not caused by viruses or alcohol. Fibrotic hepatitis, cirrhosis, and hepatocellular carcinoma can develop. The recent increase in NAFLD incidence worldwide has stimulated drug development efforts. However, there is s...

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Veröffentlicht in:	Physiological research 2023-07, Vol.72 (3), p.371-382
Hauptverfasser:	Saigo, Y, Sasase, T, Tohma, M, Uno, K, Shinozaki, Y, Maekawa, T, Sano, R, Miyajima, K, Ohta, T
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Hydroxypropyl-beta-cyclodextrin - metabolism 2-Hydroxypropyl-beta-cyclodextrin - therapeutic use Age Alanine transaminase Animal models Animals Aspartate aminotransferase Autopsy Blood levels Cholesterol Cholic acid Cirrhosis Diet Diet, High-Fat - adverse effects Disease Models, Animal Drug development Endoplasmic reticulum Fatty liver Female Females Fibrosis Gene expression Hepatitis Hepatocellular carcinoma High cholesterol diet Humans Hypercholesterolemia - metabolism Hyperlipidemias Hypotheses Inflammation Lipids Liver - metabolism Liver cancer Liver cirrhosis Liver diseases Metabolic syndrome Metabolism Non-alcoholic Fatty Liver Disease - chemically induced Overnutrition Oxidative stress Pathogenesis Pathology Pathophysiology Rats Rats, Sprague-Dawley Triglycerides β-Cyclodextrin
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