Alternative Mechanisms of Mutagenesis at mCpG Sites during Replication and Repair

5-Methyl-2'-deoxycytidine (mC) at CpG sites plays a key role in the epigenetic gene regulation, cell differentiation, and carcinogenesis. Despite the importance of mC for normal cell function, CpG dinucleotides are known as mutagenesis hotspots. Deamination of mC yields T, causing C→T transitio...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Molecular biology (New York) 2023-08, Vol.57 (4), p.584-592
Hauptverfasser:	Shilkin, E. S., Petrova, D. V., Zharkov, D. O., Makarova, A. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Carcinogenesis Cell differentiation CpG islands Deamination DNA repair DNA-directed DNA polymerase Epigenetics Gene regulation Human Genetics Life Sciences Mutagenesis Reviews
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!