Alternative Mechanisms of Mutagenesis at mCpG Sites during Replication and Repair
5-Methyl-2'-deoxycytidine (mC) at CpG sites plays a key role in the epigenetic gene regulation, cell differentiation, and carcinogenesis. Despite the importance of mC for normal cell function, CpG dinucleotides are known as mutagenesis hotspots. Deamination of mC yields T, causing C→T transitio...
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| Veröffentlicht in: | Molecular biology (New York) 2023-08, Vol.57 (4), p.584-592 |
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| container_title | Molecular biology (New York) |
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| creator | Shilkin, E. S. Petrova, D. V. Zharkov, D. O. Makarova, A. V. |
| description | 5-Methyl-2'-deoxycytidine (mC) at CpG sites plays a key role in the epigenetic gene regulation, cell differentiation, and carcinogenesis. Despite the importance of mC for normal cell function, CpG dinucleotides are known as mutagenesis hotspots. Deamination of mC yields T, causing C→T transitions. However, several recent studies demonstrated the effect of epigenetic modifications of C on the fidelity and efficiency of DNA polymerases and excision repair enzymes. The review summarizes the available data that indicate the existence of deamination-independent mechanisms of mutagenesis at CpG sites. |
| doi_str_mv | 10.1134/S0026893323040155 |
| format | Article |
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The review summarizes the available data that indicate the existence of deamination-independent mechanisms of mutagenesis at CpG sites.</description><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Carcinogenesis</subject><subject>Cell differentiation</subject><subject>CpG islands</subject><subject>Deamination</subject><subject>DNA repair</subject><subject>DNA-directed DNA polymerase</subject><subject>Epigenetics</subject><subject>Gene regulation</subject><subject>Human Genetics</subject><subject>Life Sciences</subject><subject>Mutagenesis</subject><subject>Reviews</subject><issn>0026-8933</issn><issn>1608-3245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kN9LwzAQx4MoOKd_gG8Bn6v51Sx9HEM3YUN0-lzS9DIzurYmqeB_b8oEH0Q4-HL3vc9xdwhdU3JLKRd3W0KYVAXnjBNBaJ6foAmVRGWcifwUTUY7G_1zdBHCnhCagk3Q87yJ4Fsd3SfgDZh33bpwCLizeDNEvYMWggtYR3xY9Eu8dRECrgfv2h1-gb5xJqFdi3Vbj7l2_hKdWd0EuPrRKXp7uH9drLL10_JxMV9nhlMZM8VlQUFJU0gjc2qT0poVdW24qGZ6rFfcaqvS_rRiapYDU5wXoqrBVoTwKbo5zu199zFAiOW-G9IlTSiZEjOVi5yx1EWPXcZ3IXiwZe_dQfuvkpJy_Fz553OJYUcm9OOd4H8n_w99A5oObtg</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Shilkin, E. 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| subjects | Biochemistry Biomedical and Life Sciences Carcinogenesis Cell differentiation CpG islands Deamination DNA repair DNA-directed DNA polymerase Epigenetics Gene regulation Human Genetics Life Sciences Mutagenesis Reviews |
| title | Alternative Mechanisms of Mutagenesis at mCpG Sites during Replication and Repair |
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