Green tea and leukoplakia
A feasibility chemoprevention trial of green tea and oral leukoplakia has been conducted. The purpose is to demonstrate the success and pitfalls of conducting such a population-based trial within Indian rural villages. Two dosages of green tea were utilized: 3.6 g per day and 5.4 g per day. Complian...
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| Veröffentlicht in: | The American journal of surgery 1997-11, Vol.174 (5), p.552-555 |
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| creator | The Indian-US Head and Neck Cancer Cooperative Group |
| description | A feasibility chemoprevention trial of green tea and oral leukoplakia has been conducted. The purpose is to demonstrate the success and pitfalls of conducting such a population-based trial within Indian rural villages.
Two dosages of green tea were utilized: 3.6 g per day and 5.4 g per day. Compliance was measured using tea package counts and by measuring the blood concentration of the active anticancer compound in green tea, (−)-epigallocatechin-3-gallate (EGCG).
Following a 3-year planning period, 13 villages were visited, and 1,203 tobacco users were interviewed in order to identify 64 participants suitable for trial inclusion. Of the subsequently 28 consenting individuals entered, 23 remained on protocol for the entire 6-month duration. Overall compliance was excellent, with participants consuming approximately 80% of prescribed packets.
These results provide a basis for continuing international collaborative efforts in conducting population-based chemoprevention trials against head and neck cancer. |
| doi_str_mv | 10.1016/S0002-9610(97)00148-7 |
| format | Article |
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Two dosages of green tea were utilized: 3.6 g per day and 5.4 g per day. Compliance was measured using tea package counts and by measuring the blood concentration of the active anticancer compound in green tea, (−)-epigallocatechin-3-gallate (EGCG).
Following a 3-year planning period, 13 villages were visited, and 1,203 tobacco users were interviewed in order to identify 64 participants suitable for trial inclusion. Of the subsequently 28 consenting individuals entered, 23 remained on protocol for the entire 6-month duration. Overall compliance was excellent, with participants consuming approximately 80% of prescribed packets.
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Two dosages of green tea were utilized: 3.6 g per day and 5.4 g per day. Compliance was measured using tea package counts and by measuring the blood concentration of the active anticancer compound in green tea, (−)-epigallocatechin-3-gallate (EGCG).
Following a 3-year planning period, 13 villages were visited, and 1,203 tobacco users were interviewed in order to identify 64 participants suitable for trial inclusion. Of the subsequently 28 consenting individuals entered, 23 remained on protocol for the entire 6-month duration. Overall compliance was excellent, with participants consuming approximately 80% of prescribed packets.
These results provide a basis for continuing international collaborative efforts in conducting population-based chemoprevention trials against head and neck cancer.</description><subject>Biological and medical sciences</subject><subject>Blood levels</subject><subject>Ent. Stomatology</subject><subject>Epigallocatechin gallate</subject><subject>Green tea</subject><subject>Head & neck cancer</subject><subject>Leukokeratosis</subject><subject>Medical sciences</subject><subject>Pharmacology. 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Stomatology</topic><topic>Epigallocatechin gallate</topic><topic>Green tea</topic><topic>Head & neck cancer</topic><topic>Leukokeratosis</topic><topic>Medical sciences</topic><topic>Pharmacology. 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The purpose is to demonstrate the success and pitfalls of conducting such a population-based trial within Indian rural villages.
Two dosages of green tea were utilized: 3.6 g per day and 5.4 g per day. Compliance was measured using tea package counts and by measuring the blood concentration of the active anticancer compound in green tea, (−)-epigallocatechin-3-gallate (EGCG).
Following a 3-year planning period, 13 villages were visited, and 1,203 tobacco users were interviewed in order to identify 64 participants suitable for trial inclusion. Of the subsequently 28 consenting individuals entered, 23 remained on protocol for the entire 6-month duration. Overall compliance was excellent, with participants consuming approximately 80% of prescribed packets.
These results provide a basis for continuing international collaborative efforts in conducting population-based chemoprevention trials against head and neck cancer.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><doi>10.1016/S0002-9610(97)00148-7</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9610 |
| ispartof | The American journal of surgery, 1997-11, Vol.174 (5), p.552-555 |
| issn | 0002-9610 1879-1883 |
| language | eng |
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| source | ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Biological and medical sciences Blood levels Ent. Stomatology Epigallocatechin gallate Green tea Head & neck cancer Leukokeratosis Medical sciences Pharmacology. Drug treatments Tea Tobacco Villages |
| title | Green tea and leukoplakia |
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