Serotonin type-3 receptor antagonists selectively kill melanoma cells through classical apoptosis, microtubule depolymerisation, ERK activation, and NF-κB downregulation

Malignant melanoma is a highly metastatic tumour, resistant to treatment. Serotonin type-3 (5-HT 3 ) receptor antagonists, such as tropisetron and ondansetron, are well-tolerated antiemetic drugs commonly used to prevent nausea caused by chemotherapy or radiotherapy. We investigated the anticancer e...

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Veröffentlicht in:	Cell biology and toxicology 2023-06, Vol.39 (3), p.1119-1135
Hauptverfasser:	Barzegar-fallah, Anita, Alimoradi, Houman, Dunlop, Jessica L., Torbati, Elham, Baird, Sarah K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antiemetics Antiemetics - adverse effects Apoptosis Binding sites Biochemistry Biomedical and Life Sciences Calcium permeability Caspase-3 Cell Biology Cell cycle Cell death Chemotherapy Colchicine Cytoskeleton Cytotoxicity Data analysis Depolymerization Down-Regulation Drugs Extracellular signal-regulated kinase Flow cytometry Fluorescence Humans Life Sciences Melanoma Melanoma - drug therapy Membrane permeability Metastases Microtubules Mitochondrial DNA Molecular docking Molecular Docking Simulation NF-kappa B NF-κB protein Ondansetron - adverse effects Original Article Paclitaxel Paclitaxel - pharmacology Pharmacology/Toxicology Phosphatidylserine Radiation therapy Receptors Serotonin Serotonin - adverse effects Serotonin S3 receptors Skin cancer Treatment resistance Tropisetron - adverse effects Tumor cell lines Tumors Variance analysis Vomiting - chemically induced Vomiting - drug therapy Vomiting - prevention & control Western blotting
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