Depletion of microglia with PLX3397 attenuates MK-801-induced hyperactivity associated with regulating inflammation-related genes in the brain

Acute administration of MK-801 (dizocilpine), an N-methyl-D-aspartate receptor (NMDAR) antagonist, can establish animal models of psychiatric disorders. However, the roles of microglia and inflammation-related genes in these animal models of psychiatric disorders remain unknown. Here, we found rapid...

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Veröffentlicht in:	Dōngwùxué yánjiū 2023-05, Vol.44 (3), p.543-555
Hauptverfasser:	Ni, Rong-Jun, Wang, Yi-Yan, Gao, Tian-Hao, Wang, Qi-Run, Wei, Jin-Xue, Zhao, Lian-Sheng, Ma, Yang-Rui, Ma, Xiao-Hong, Li, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Behavior Brain Brain - metabolism c-Kit protein CD11b antigen CD163 antigen Cluster analysis Clustering Colonies Colony-stimulating factor Correlation analysis CX3CR1 protein Depletion Disorders Dizocilpine Dizocilpine Maleate - metabolism Dizocilpine Maleate - pharmacology Drinking water Enzyme inhibitors Field tests gamma-Aminobutyric Acid - metabolism Gene expression Genes Genetic engineering Glutamate receptors Hyperactivity Inflammation Inflammation - chemically induced Inflammation - drug therapy Inflammation - genetics Inflammation - veterinary Inhibitors Kinases Macrophage colony-stimulating factor Membrane Glycoproteins - metabolism Mental disorders Mice Microglia Microglia - metabolism Minocycline N-Methyl-D-aspartic acid receptors Open-field behavior Prefrontal cortex Receptors Receptors, Immunologic - metabolism Repopulation Schizophrenia γ-Aminobutyric acid
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