Advances in combined application of dental stem cells and small-molecule drugs in regenerative medicine

Teeth are a kind of masticatory organs of special histological origin, unique to vertebrates, playing an important role in chewing, esthetics, and auxiliary pronunciation. In the past decades, with the development of tissue engineering and regenerative medicine, the studies of mesenchymal stem cells...

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Veröffentlicht in:Human cell : official journal of Human Cell Research Society 2023-09, Vol.36 (5), p.1620-1637
Hauptverfasser: Zheng, Zejun, Tang, Shuai, Yang, Tong, Wang, Xiaolan, Ding, Gang
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container_issue 5
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container_title Human cell : official journal of Human Cell Research Society
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creator Zheng, Zejun
Tang, Shuai
Yang, Tong
Wang, Xiaolan
Ding, Gang
description Teeth are a kind of masticatory organs of special histological origin, unique to vertebrates, playing an important role in chewing, esthetics, and auxiliary pronunciation. In the past decades, with the development of tissue engineering and regenerative medicine, the studies of mesenchymal stem cells (MSCs) gradually attracted the interest of researchers. Accordingly, several types of MSCs have been successively isolated in teeth or teeth-related tissues, including dental pulp stem cells, periodontal ligament stem cells, stem cells from human exfoliated deciduous teeth, dental follicle stem cells, stem cells from apical papilla and gingival mesenchymal stem cells. These dental stem cells (DSCs) are easily accessible, possess excellent stem cell characteristics, such as high proliferation rates and profound immunomodulatory properties. Small-molecule drugs are widely used and show great advantages in clinical practice. As research progressed, small-molecule drugs are found to have various complex effects on the characteristics of DSCs, especially the enhancement of biological characteristics of DSCs, which has gradually become a hot issue in the field of DSCs research. This review summarizes the background, current status, existing problems, future research directions, and prospects of the combination of DSCs with three common small-molecule drugs: aspirin, metformin, and berberine.
doi_str_mv 10.1007/s13577-023-00943-1
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subjects Aspirin
Berberine
Biomedical and Life Sciences
Cell Biology
Dental pulp
Drugs
Gynecology
Immunomodulation
Life Sciences
Mastication
Mesenchymal stem cells
Metformin
Oncology
Periodontal ligament
Regenerative medicine
Reproductive Medicine
Review Article
Stem Cells
Surgery
Teeth
Tissue engineering
title Advances in combined application of dental stem cells and small-molecule drugs in regenerative medicine
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