Cardiac involvement in a case of juvenile dermatomyositis with positive anti‐melanoma differentiation associated protein 5 antibody
Juvenile dermatomyositis (JDM) is an autoimmune disease characterized by muscle weakness and specific skin lesions, as well as non‐muscular involvement such as interstitial lung disease (ILD), cardiac involvement and arthritis. Anti‐melanoma differentiation‐associated protein 5 (anti‐MDA5)‐positive...
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| Veröffentlicht in: | International journal of rheumatic diseases 2023-08, Vol.26 (8), p.1582-1585 |
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| container_title | International journal of rheumatic diseases |
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| creator | Kaplan, Melike Mehveş Çelikel, Elif Güngörer, Vildan Ekici Tekin, Zahide Gürsu, Hazım Alper Polat, Sanem Eryılmaz Cinel, Güzin Çelikel Acar, Banu |
| description | Juvenile dermatomyositis (JDM) is an autoimmune disease characterized by muscle weakness and specific skin lesions, as well as non‐muscular involvement such as interstitial lung disease (ILD), cardiac involvement and arthritis. Anti‐melanoma differentiation‐associated protein 5 (anti‐MDA5)‐positive JDM patients are typically characterized by the presence of skin ulcers and rapidly progressing ILD (RP‐ILD). Although cardiac involvement is not an expected involvement in anti‐MDA5‐positive JDM cases, it is significant because it can be fatal. In this report, an anti‐MDA5 myositis‐specific autoantibody‐positive JDM case referred with the diagnosis of psoriatic arthritis in whom cardiomyopathy and arrhythmia were detected in follow‐up is presented. Since cardiac involvement is associated with mortality, it would be useful to follow up anti‐MDA5 positive patients for cardiac involvement in addition to lung involvement. Tofacitinib is a promising treatment option in treatment‐resistant JDM. |
| doi_str_mv | 10.1111/1756-185X.14630 |
| format | Article |
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Anti‐melanoma differentiation‐associated protein 5 (anti‐MDA5)‐positive JDM patients are typically characterized by the presence of skin ulcers and rapidly progressing ILD (RP‐ILD). Although cardiac involvement is not an expected involvement in anti‐MDA5‐positive JDM cases, it is significant because it can be fatal. In this report, an anti‐MDA5 myositis‐specific autoantibody‐positive JDM case referred with the diagnosis of psoriatic arthritis in whom cardiomyopathy and arrhythmia were detected in follow‐up is presented. Since cardiac involvement is associated with mortality, it would be useful to follow up anti‐MDA5 positive patients for cardiac involvement in addition to lung involvement. Tofacitinib is a promising treatment option in treatment‐resistant JDM.</description><identifier>ISSN: 1756-1841</identifier><identifier>EISSN: 1756-185X</identifier><identifier>DOI: 10.1111/1756-185X.14630</identifier><identifier>PMID: 36852875</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>anti‐MDA5 ; Arrhythmia ; Autoantibodies ; Autoimmune diseases ; cardiac involvement ; Cardiomyopathy ; Coronary artery disease ; Dermatomyositis ; Heart diseases ; juvenile dermatomyositis ; Lung diseases ; Melanoma ; Myositis ; Psoriatic arthritis ; Skin diseases ; Skin lesions ; Ulcers</subject><ispartof>International journal of rheumatic diseases, 2023-08, Vol.26 (8), p.1582-1585</ispartof><rights>2023 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.</rights><rights>International Journal of Rheumatic Diseases © 2023 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3380-32f1a8a0a544d20f15a85f2359ff120dd7813b2905859604804282dbc1f074343</citedby><cites>FETCH-LOGICAL-c3380-32f1a8a0a544d20f15a85f2359ff120dd7813b2905859604804282dbc1f074343</cites><orcidid>0000-0003-0129-4410 ; 0000-0003-2309-7952 ; 0000-0002-6209-196X ; 0000-0002-0707-2678 ; 0000-0002-5446-667X ; 0000-0002-8012-2774 ; 0000-0002-9838-2603 ; 0000-0002-1808-3655</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1756-185X.14630$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1756-185X.14630$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36852875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaplan, Melike Mehveş</creatorcontrib><creatorcontrib>Çelikel, Elif</creatorcontrib><creatorcontrib>Güngörer, Vildan</creatorcontrib><creatorcontrib>Ekici Tekin, Zahide</creatorcontrib><creatorcontrib>Gürsu, Hazım Alper</creatorcontrib><creatorcontrib>Polat, Sanem Eryılmaz</creatorcontrib><creatorcontrib>Cinel, Güzin</creatorcontrib><creatorcontrib>Çelikel Acar, Banu</creatorcontrib><title>Cardiac involvement in a case of juvenile dermatomyositis with positive anti‐melanoma differentiation associated protein 5 antibody</title><title>International journal of rheumatic diseases</title><addtitle>Int J Rheum Dis</addtitle><description>Juvenile dermatomyositis (JDM) is an autoimmune disease characterized by muscle weakness and specific skin lesions, as well as non‐muscular involvement such as interstitial lung disease (ILD), cardiac involvement and arthritis. Anti‐melanoma differentiation‐associated protein 5 (anti‐MDA5)‐positive JDM patients are typically characterized by the presence of skin ulcers and rapidly progressing ILD (RP‐ILD). Although cardiac involvement is not an expected involvement in anti‐MDA5‐positive JDM cases, it is significant because it can be fatal. In this report, an anti‐MDA5 myositis‐specific autoantibody‐positive JDM case referred with the diagnosis of psoriatic arthritis in whom cardiomyopathy and arrhythmia were detected in follow‐up is presented. Since cardiac involvement is associated with mortality, it would be useful to follow up anti‐MDA5 positive patients for cardiac involvement in addition to lung involvement. Tofacitinib is a promising treatment option in treatment‐resistant JDM.</description><subject>anti‐MDA5</subject><subject>Arrhythmia</subject><subject>Autoantibodies</subject><subject>Autoimmune diseases</subject><subject>cardiac involvement</subject><subject>Cardiomyopathy</subject><subject>Coronary artery disease</subject><subject>Dermatomyositis</subject><subject>Heart diseases</subject><subject>juvenile dermatomyositis</subject><subject>Lung diseases</subject><subject>Melanoma</subject><subject>Myositis</subject><subject>Psoriatic arthritis</subject><subject>Skin diseases</subject><subject>Skin lesions</subject><subject>Ulcers</subject><issn>1756-1841</issn><issn>1756-185X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqFkLtOwzAUhi0EolCY2ZAl5rS-Ju5YVdykSjCAxGY5sS1cNXGxk1bdWNh5Rp4E90JXvPgc6z_fsT4ArjAa4HSGuOB5hgV_G2CWU3QEzg4vx4ea4R44j3GGUI5pXpyCHs0FJ6LgZ-BrooJ2qoKuWfr50tSmaVMNFaxUNNBbOOuWpnFzA7UJtWp9vfbRtS7ClWvf4WLbLA1UTet-Pr9rM1eNrxXUzloTEs2p1vkEjNFXqTYaLoJvTdrBt0Ol1-sLcGLVPJrL_d0Hr3e3L5OHbPp0_zgZT7OKUoEySixWQiHFGdMEWcyV4JZQPrIWE6R1ITAtyQhxwUc5YgIxIoguK2xRwSijfXCz46YvfHQmtnLmu9CklZIIxjAjpEApNdylquBjDMbKRXC1CmuJkdxolxuxciNZbrWnies9tytrow_5P88pwHeBVTK5_o8nx8_THfgXKyqPIg</recordid><startdate>202308</startdate><enddate>202308</enddate><creator>Kaplan, Melike Mehveş</creator><creator>Çelikel, Elif</creator><creator>Güngörer, Vildan</creator><creator>Ekici Tekin, Zahide</creator><creator>Gürsu, Hazım Alper</creator><creator>Polat, Sanem Eryılmaz</creator><creator>Cinel, Güzin</creator><creator>Çelikel Acar, Banu</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><orcidid>https://orcid.org/0000-0003-0129-4410</orcidid><orcidid>https://orcid.org/0000-0003-2309-7952</orcidid><orcidid>https://orcid.org/0000-0002-6209-196X</orcidid><orcidid>https://orcid.org/0000-0002-0707-2678</orcidid><orcidid>https://orcid.org/0000-0002-5446-667X</orcidid><orcidid>https://orcid.org/0000-0002-8012-2774</orcidid><orcidid>https://orcid.org/0000-0002-9838-2603</orcidid><orcidid>https://orcid.org/0000-0002-1808-3655</orcidid></search><sort><creationdate>202308</creationdate><title>Cardiac involvement in a case of juvenile dermatomyositis with positive anti‐melanoma differentiation associated protein 5 antibody</title><author>Kaplan, Melike Mehveş ; Çelikel, Elif ; Güngörer, Vildan ; Ekici Tekin, Zahide ; Gürsu, Hazım Alper ; Polat, Sanem Eryılmaz ; Cinel, Güzin ; Çelikel Acar, Banu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3380-32f1a8a0a544d20f15a85f2359ff120dd7813b2905859604804282dbc1f074343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>anti‐MDA5</topic><topic>Arrhythmia</topic><topic>Autoantibodies</topic><topic>Autoimmune diseases</topic><topic>cardiac involvement</topic><topic>Cardiomyopathy</topic><topic>Coronary artery disease</topic><topic>Dermatomyositis</topic><topic>Heart diseases</topic><topic>juvenile dermatomyositis</topic><topic>Lung diseases</topic><topic>Melanoma</topic><topic>Myositis</topic><topic>Psoriatic arthritis</topic><topic>Skin diseases</topic><topic>Skin lesions</topic><topic>Ulcers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaplan, Melike Mehveş</creatorcontrib><creatorcontrib>Çelikel, Elif</creatorcontrib><creatorcontrib>Güngörer, Vildan</creatorcontrib><creatorcontrib>Ekici Tekin, Zahide</creatorcontrib><creatorcontrib>Gürsu, Hazım Alper</creatorcontrib><creatorcontrib>Polat, Sanem Eryılmaz</creatorcontrib><creatorcontrib>Cinel, Güzin</creatorcontrib><creatorcontrib>Çelikel Acar, Banu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>International journal of rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaplan, Melike Mehveş</au><au>Çelikel, Elif</au><au>Güngörer, Vildan</au><au>Ekici Tekin, Zahide</au><au>Gürsu, Hazım Alper</au><au>Polat, Sanem Eryılmaz</au><au>Cinel, Güzin</au><au>Çelikel Acar, Banu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac involvement in a case of juvenile dermatomyositis with positive anti‐melanoma differentiation associated protein 5 antibody</atitle><jtitle>International journal of rheumatic diseases</jtitle><addtitle>Int J Rheum Dis</addtitle><date>2023-08</date><risdate>2023</risdate><volume>26</volume><issue>8</issue><spage>1582</spage><epage>1585</epage><pages>1582-1585</pages><issn>1756-1841</issn><eissn>1756-185X</eissn><abstract>Juvenile dermatomyositis (JDM) is an autoimmune disease characterized by muscle weakness and specific skin lesions, as well as non‐muscular involvement such as interstitial lung disease (ILD), cardiac involvement and arthritis. Anti‐melanoma differentiation‐associated protein 5 (anti‐MDA5)‐positive JDM patients are typically characterized by the presence of skin ulcers and rapidly progressing ILD (RP‐ILD). Although cardiac involvement is not an expected involvement in anti‐MDA5‐positive JDM cases, it is significant because it can be fatal. In this report, an anti‐MDA5 myositis‐specific autoantibody‐positive JDM case referred with the diagnosis of psoriatic arthritis in whom cardiomyopathy and arrhythmia were detected in follow‐up is presented. Since cardiac involvement is associated with mortality, it would be useful to follow up anti‐MDA5 positive patients for cardiac involvement in addition to lung involvement. 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| ispartof | International journal of rheumatic diseases, 2023-08, Vol.26 (8), p.1582-1585 |
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| language | eng |
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| source | Wiley Journals |
| subjects | anti‐MDA5 Arrhythmia Autoantibodies Autoimmune diseases cardiac involvement Cardiomyopathy Coronary artery disease Dermatomyositis Heart diseases juvenile dermatomyositis Lung diseases Melanoma Myositis Psoriatic arthritis Skin diseases Skin lesions Ulcers |
| title | Cardiac involvement in a case of juvenile dermatomyositis with positive anti‐melanoma differentiation associated protein 5 antibody |
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