Flexible and rigid ionic organoplatinum complexes and their antiproliferative activities

Syntheses of five (1–5) cationic organometallic complexes bearing two platinum (II) centers are being reported. Compounds 1 and 2 have a flexible molecular backbone and are isomeric. Compounds 3, 4, and 5 are structural isomers with a rigid structural framework and containing pyrimidine/pyrazine in the center and two pendant arms bearing the alkynyl–ditopic platinum units. Compounds 1–5 were systematically characterized using FT‐IR, NMR [1H, 31P{1H}, and 13C{1H}], and HRMS. The antiproliferative activity of these compounds was examined against HeLa cancer cell line, and results were compared with that of cisplatin. “Live/dead” cell death assay was performed to ratify the superior antiproliferative activities of some of these organometallic complexes with respect to cisplatin. Five cationic organoplatinum compounds (1–5) are reported. Their anticancer activity was examined against HeLa carcinoma cell lines. “Live/dead” cell death assay confirmed superior antiproliferative activities of some of the organometallic complexes with respect to cisplatin.