Protective Effect of Thymoquinone Against Morphine Injuries to Kidneys of Mice
Thymoquinone is a phytochemical compound found in the plant Nigella sativa. It has various pharmacological effects such as antioxidant and anti-apoptotic. Morphine can increase the generation of free radicals. It is mainly excreted through the kidneys and causes disturbing effects. This study was de...
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| Veröffentlicht in: | Iranian journal of kidney diseases 2017-03, Vol.11 (2), p.142 |
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| creator | Jalili, Cyrus Salahshoor, Mohammad Reza Hoseini, Mohsen Roshankhah, Shiva Sohrabi, Maryam Shabanizadeh, Ahmad |
| description | Thymoquinone is a phytochemical compound found in the plant Nigella sativa. It has various pharmacological effects such as antioxidant and anti-apoptotic. Morphine can increase the generation of free radicals. It is mainly excreted through the kidneys and causes disturbing effects. This study was designed to evaluate protective effects of thymoquinone against morphine-induced damages to the kidneys of mice.
Various doses of thymoquinone (4.5 mg/kg, 9 mg/kg, and 18 mg/kg) were intraperitoneally administered along with morphine to 48 male mice for 20 consequent days. These mice were compared with a control group with saline injection, morphine group, and groups with same doses of thymoquinone only (n = 6 in each group). Blood urea nitrogen, serum creatinine, and serum nitric oxide levels, as well kidney weight and histology were assessed after the interventions.
Morphine administration significantly decreased kidney weight and the number and mean diameter of the glomeruli. Increased levels of blood urea nitrogen, serum creatinine, and serum nitric oxide were also noted with morphine compared to the control group (P < .05). However, administration of thymoquinone and thymoquinone plus morphine significantly enhanced kidney weight, number and mean diameter of the glomeruli. All of the groups with thymoquinone were also associated with reduced blood urea nitrogen, serum creatinine, and serum nitric oxide levels compared to the morphine group (P < .05).
It seems that antioxidant and anti-apoptotic effects of thymoquinone could protect of the kidneys against damage due to morphine toxicity. |
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Various doses of thymoquinone (4.5 mg/kg, 9 mg/kg, and 18 mg/kg) were intraperitoneally administered along with morphine to 48 male mice for 20 consequent days. These mice were compared with a control group with saline injection, morphine group, and groups with same doses of thymoquinone only (n = 6 in each group). Blood urea nitrogen, serum creatinine, and serum nitric oxide levels, as well kidney weight and histology were assessed after the interventions.
Morphine administration significantly decreased kidney weight and the number and mean diameter of the glomeruli. Increased levels of blood urea nitrogen, serum creatinine, and serum nitric oxide were also noted with morphine compared to the control group (P < .05). However, administration of thymoquinone and thymoquinone plus morphine significantly enhanced kidney weight, number and mean diameter of the glomeruli. All of the groups with thymoquinone were also associated with reduced blood urea nitrogen, serum creatinine, and serum nitric oxide levels compared to the morphine group (P < .05).
It seems that antioxidant and anti-apoptotic effects of thymoquinone could protect of the kidneys against damage due to morphine toxicity.</description><identifier>ISSN: 1735-8582</identifier><identifier>EISSN: 1735-8604</identifier><identifier>PMID: 28270647</identifier><language>eng</language><publisher>Iran: Iranian Society of Nephrology</publisher><subject>Acute Kidney Injury - chemically induced ; Acute Kidney Injury - drug therapy ; Animals ; Antioxidants - administration & dosage ; Benzoquinones - administration & dosage ; Blood Urea Nitrogen ; Creatinine ; Creatinine - analysis ; Kidney - drug effects ; Kidney - pathology ; Kidneys ; Male ; Mice ; Mice, Inbred BALB C ; Models, Animal ; Morphine ; Morphine - toxicity ; Nigella sativa - chemistry ; Nitric oxide ; Nitric Oxide - blood ; Nitrogen ; Oxidative Stress - drug effects ; Phytotherapy ; Random Allocation</subject><ispartof>Iranian journal of kidney diseases, 2017-03, Vol.11 (2), p.142</ispartof><rights>Copyright Iranian Society of Nephrology Mar 2017</rights><rights>Copyright Iranian Society of Nephrology 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28270647$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jalili, Cyrus</creatorcontrib><creatorcontrib>Salahshoor, Mohammad Reza</creatorcontrib><creatorcontrib>Hoseini, Mohsen</creatorcontrib><creatorcontrib>Roshankhah, Shiva</creatorcontrib><creatorcontrib>Sohrabi, Maryam</creatorcontrib><creatorcontrib>Shabanizadeh, Ahmad</creatorcontrib><title>Protective Effect of Thymoquinone Against Morphine Injuries to Kidneys of Mice</title><title>Iranian journal of kidney diseases</title><addtitle>Iran J Kidney Dis</addtitle><description>Thymoquinone is a phytochemical compound found in the plant Nigella sativa. It has various pharmacological effects such as antioxidant and anti-apoptotic. Morphine can increase the generation of free radicals. It is mainly excreted through the kidneys and causes disturbing effects. This study was designed to evaluate protective effects of thymoquinone against morphine-induced damages to the kidneys of mice.
Various doses of thymoquinone (4.5 mg/kg, 9 mg/kg, and 18 mg/kg) were intraperitoneally administered along with morphine to 48 male mice for 20 consequent days. These mice were compared with a control group with saline injection, morphine group, and groups with same doses of thymoquinone only (n = 6 in each group). Blood urea nitrogen, serum creatinine, and serum nitric oxide levels, as well kidney weight and histology were assessed after the interventions.
Morphine administration significantly decreased kidney weight and the number and mean diameter of the glomeruli. Increased levels of blood urea nitrogen, serum creatinine, and serum nitric oxide were also noted with morphine compared to the control group (P < .05). However, administration of thymoquinone and thymoquinone plus morphine significantly enhanced kidney weight, number and mean diameter of the glomeruli. All of the groups with thymoquinone were also associated with reduced blood urea nitrogen, serum creatinine, and serum nitric oxide levels compared to the morphine group (P < .05).
It seems that antioxidant and anti-apoptotic effects of thymoquinone could protect of the kidneys against damage due to morphine toxicity.</description><subject>Acute Kidney Injury - chemically induced</subject><subject>Acute Kidney Injury - drug therapy</subject><subject>Animals</subject><subject>Antioxidants - administration & dosage</subject><subject>Benzoquinones - administration & dosage</subject><subject>Blood Urea Nitrogen</subject><subject>Creatinine</subject><subject>Creatinine - analysis</subject><subject>Kidney - drug effects</subject><subject>Kidney - pathology</subject><subject>Kidneys</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Models, Animal</subject><subject>Morphine</subject><subject>Morphine - toxicity</subject><subject>Nigella sativa - chemistry</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - blood</subject><subject>Nitrogen</subject><subject>Oxidative Stress - drug effects</subject><subject>Phytotherapy</subject><subject>Random Allocation</subject><issn>1735-8582</issn><issn>1735-8604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kF1LwzAYhYMobk7_ggS8LuQ72eUYU4ebejGvS9q-cSmuqUkr9N-v4nbr1TkcnveDc4GmVHOZGUXE5dlLwyboJqWaEMXnglyjCTNMEyX0FL2-x9BB2fkfwCvnRoeDw7v9cAjfvW9CA3jxaX2TOrwNsd37MVg3dR89JNwF_OKrBob0O7T1JdyiK2e_EtyddIY-Hle75XO2eXtaLxebrGVcdBnTBSspdcYSacqCc5CFphYqB1Bx5goGUjGlSuWkVYY5XknNLBVgrC1K4DP08Le3jeOfkLq8Dn1sxpM5M4IoTblS_1HU6PmcaaHMSN2fqL44QJW30R9sHPJzSfwIV_5jnA</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Jalili, Cyrus</creator><creator>Salahshoor, Mohammad Reza</creator><creator>Hoseini, Mohsen</creator><creator>Roshankhah, Shiva</creator><creator>Sohrabi, Maryam</creator><creator>Shabanizadeh, Ahmad</creator><general>Iranian Society of Nephrology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20170301</creationdate><title>Protective Effect of Thymoquinone Against Morphine Injuries to Kidneys of Mice</title><author>Jalili, Cyrus ; Salahshoor, Mohammad Reza ; Hoseini, Mohsen ; Roshankhah, Shiva ; Sohrabi, Maryam ; Shabanizadeh, Ahmad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p234t-27b2c11f8a058cb33e5b71aedfeed32fb2e56266c6f5a682f3d572a14e8aabce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acute Kidney Injury - chemically induced</topic><topic>Acute Kidney Injury - drug therapy</topic><topic>Animals</topic><topic>Antioxidants - administration & dosage</topic><topic>Benzoquinones - administration & dosage</topic><topic>Blood Urea Nitrogen</topic><topic>Creatinine</topic><topic>Creatinine - analysis</topic><topic>Kidney - drug effects</topic><topic>Kidney - pathology</topic><topic>Kidneys</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Models, Animal</topic><topic>Morphine</topic><topic>Morphine - toxicity</topic><topic>Nigella sativa - chemistry</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - blood</topic><topic>Nitrogen</topic><topic>Oxidative Stress - drug effects</topic><topic>Phytotherapy</topic><topic>Random Allocation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jalili, Cyrus</creatorcontrib><creatorcontrib>Salahshoor, Mohammad Reza</creatorcontrib><creatorcontrib>Hoseini, Mohsen</creatorcontrib><creatorcontrib>Roshankhah, Shiva</creatorcontrib><creatorcontrib>Sohrabi, Maryam</creatorcontrib><creatorcontrib>Shabanizadeh, Ahmad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Iranian journal of kidney diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jalili, Cyrus</au><au>Salahshoor, Mohammad Reza</au><au>Hoseini, Mohsen</au><au>Roshankhah, Shiva</au><au>Sohrabi, Maryam</au><au>Shabanizadeh, Ahmad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective Effect of Thymoquinone Against Morphine Injuries to Kidneys of Mice</atitle><jtitle>Iranian journal of kidney diseases</jtitle><addtitle>Iran J Kidney Dis</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>11</volume><issue>2</issue><spage>142</spage><pages>142-</pages><issn>1735-8582</issn><eissn>1735-8604</eissn><abstract>Thymoquinone is a phytochemical compound found in the plant Nigella sativa. It has various pharmacological effects such as antioxidant and anti-apoptotic. Morphine can increase the generation of free radicals. It is mainly excreted through the kidneys and causes disturbing effects. This study was designed to evaluate protective effects of thymoquinone against morphine-induced damages to the kidneys of mice.
Various doses of thymoquinone (4.5 mg/kg, 9 mg/kg, and 18 mg/kg) were intraperitoneally administered along with morphine to 48 male mice for 20 consequent days. These mice were compared with a control group with saline injection, morphine group, and groups with same doses of thymoquinone only (n = 6 in each group). Blood urea nitrogen, serum creatinine, and serum nitric oxide levels, as well kidney weight and histology were assessed after the interventions.
Morphine administration significantly decreased kidney weight and the number and mean diameter of the glomeruli. Increased levels of blood urea nitrogen, serum creatinine, and serum nitric oxide were also noted with morphine compared to the control group (P < .05). However, administration of thymoquinone and thymoquinone plus morphine significantly enhanced kidney weight, number and mean diameter of the glomeruli. All of the groups with thymoquinone were also associated with reduced blood urea nitrogen, serum creatinine, and serum nitric oxide levels compared to the morphine group (P < .05).
It seems that antioxidant and anti-apoptotic effects of thymoquinone could protect of the kidneys against damage due to morphine toxicity.</abstract><cop>Iran</cop><pub>Iranian Society of Nephrology</pub><pmid>28270647</pmid></addata></record> |
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| subjects | Acute Kidney Injury - chemically induced Acute Kidney Injury - drug therapy Animals Antioxidants - administration & dosage Benzoquinones - administration & dosage Blood Urea Nitrogen Creatinine Creatinine - analysis Kidney - drug effects Kidney - pathology Kidneys Male Mice Mice, Inbred BALB C Models, Animal Morphine Morphine - toxicity Nigella sativa - chemistry Nitric oxide Nitric Oxide - blood Nitrogen Oxidative Stress - drug effects Phytotherapy Random Allocation |
| title | Protective Effect of Thymoquinone Against Morphine Injuries to Kidneys of Mice |
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