Complement component C1q is an immunological rheostat that regulates Fc:FcγR interactions

Though binding sites for the complement factor C1q and the canonical fragment crystallizable (Fc) gamma receptors (Fc γ Rs) on immunoglobulin G (IgG) molecules overlap, how C1q decoration of immune complexes (ICs) influences their ability to engage Fc γ Rs remains unknown. In this report, we use rec...

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Veröffentlicht in:	Immunogenetics (New York) 2023-08, Vol.75 (4), p.369-383
Hauptverfasser:	So, Edward C., Zhou, Hua, Greenwell, Ariana, Burch, Erin E., Ji, Yaping, Mérigeon, Emmanuel Y., Olsen, Henrik S., Bentzen, Søren M., Block, David S., Zhang, Xiaoyu, Strome, Scott E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergology Antibodies Antibody-dependent cell-mediated cytotoxicity Antigen-antibody complexes Binding sites Biomedical and Life Sciences Biomedicine CD137 antigen CD16 antigen Cell activation Cell Biology Complement Complement component C1q Cytotoxicity Fc receptors Gene Function Homeostasis Human Genetics IgG antibody Immune system Immunoglobulin G Immunoglobulins Immunology Natural killer cells Original Article Otolaryngology Proteins Toxicity
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