Osteonecrosis of the femoral head in SARS patients: seven years later
This study is aimed to explore the progression of osteonecrosis of the femoral head (OFNH) in severe acute respiratory syndrome patients 7 years after steroid administration and to analyze factors affecting the prognosis. One-hundred and ninety hips in 117 patients with more than 7 years of follow-u...
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| Veröffentlicht in: | European journal of orthopaedic surgery & traumatology 2013-08, Vol.23 (6), p.671-677 |
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| creator | Zhao, Feng-Chao Guo, Kai-Jin Li, Zi-Rong |
| description | This study is aimed to explore the progression of osteonecrosis of the femoral head (OFNH) in severe acute respiratory syndrome patients 7 years after steroid administration and to analyze factors affecting the prognosis. One-hundred and ninety hips in 117 patients with more than 7 years of follow-up were studied. The prevalence of progression to symptoms and collapse was determined. The total dose of steroid, gender, age, stage, lesion location, volume of necrosis, viable lateral column and bone marrow edema were analyzed and correlated with progression. During the 7 years of follow-up, 66 hips progressed to symptoms, 50 hips collapsed and 10 hips showed complete regression. Fifty-seven hips (86.36 %) caused pain and 32 (64.00 %) collapsed within 3 years of steroid administration. The lesion was relatively larger, and there was relatively less viable lateral column in hips that exhibited symptoms or collapsed. Mechanical failure of the necrotic segment of bone principally occurred within 3 years after the administration of steroids. Larger lesions and less viable lateral column were the main risk factors for progression. Small ONFH lesions seldom collapsed. |
| doi_str_mv | 10.1007/s00590-012-1054-4 |
| format | Article |
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One-hundred and ninety hips in 117 patients with more than 7 years of follow-up were studied. The prevalence of progression to symptoms and collapse was determined. The total dose of steroid, gender, age, stage, lesion location, volume of necrosis, viable lateral column and bone marrow edema were analyzed and correlated with progression. During the 7 years of follow-up, 66 hips progressed to symptoms, 50 hips collapsed and 10 hips showed complete regression. Fifty-seven hips (86.36 %) caused pain and 32 (64.00 %) collapsed within 3 years of steroid administration. The lesion was relatively larger, and there was relatively less viable lateral column in hips that exhibited symptoms or collapsed. Mechanical failure of the necrotic segment of bone principally occurred within 3 years after the administration of steroids. Larger lesions and less viable lateral column were the main risk factors for progression. 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One-hundred and ninety hips in 117 patients with more than 7 years of follow-up were studied. The prevalence of progression to symptoms and collapse was determined. The total dose of steroid, gender, age, stage, lesion location, volume of necrosis, viable lateral column and bone marrow edema were analyzed and correlated with progression. During the 7 years of follow-up, 66 hips progressed to symptoms, 50 hips collapsed and 10 hips showed complete regression. Fifty-seven hips (86.36 %) caused pain and 32 (64.00 %) collapsed within 3 years of steroid administration. The lesion was relatively larger, and there was relatively less viable lateral column in hips that exhibited symptoms or collapsed. Mechanical failure of the necrotic segment of bone principally occurred within 3 years after the administration of steroids. Larger lesions and less viable lateral column were the main risk factors for progression. Small ONFH lesions seldom collapsed.</description><subject>Adult</subject><subject>Bone Transplantation</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Femur Head Necrosis - chemically induced</subject><subject>Femur Head Necrosis - diagnosis</subject><subject>Femur Head Necrosis - surgery</subject><subject>Follow-Up Studies</subject><subject>Glucocorticoids - adverse effects</subject><subject>Hip Joint - pathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Necrosis</subject><subject>Original Article</subject><subject>Pain - etiology</subject><subject>Prednisolone - adverse effects</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Severe Acute Respiratory Syndrome - complications</subject><subject>Steroids</subject><subject>Surgical Orthopedics</subject><subject>Traumatic Surgery</subject><subject>Young Adult</subject><issn>1633-8065</issn><issn>1432-1068</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1Lw0AQhhdRbK3-AC-y4Dk6-5XseiulfkChYPW8bLIT29ImdTcV-u9NSNWTc5kZ5p13mIeQawZ3DCC7jwDKQAKMJwyUTOQJGTIpui7Vp22dCpFoSNWAXMS4BmDKMHVOBlxIxpnOhmQ6jw3WFRahjqtI65I2S6QlbuvgNnSJztNVRRfj1wXduWaFVRMfaMQvrOgBXYh04xoMl-SsdJuIV8c8Iu-P07fJczKbP71MxrOkEErIxBc6S53XjglltE9NwbmRDkQOKkNfSChyLrwXKjdSpGCcdGnBtCtM6Y0sxYjc9r67UH_uMTZ2Xe9D1Z60XIuMgxFtjAjrVd1TMWBpd2G1deFgGdgOnO3B2Rac7cBZ2e7cHJ33-Rb978YPqVbAe0FsR9UHhr_T_7t-A6s3dto</recordid><startdate>201308</startdate><enddate>201308</enddate><creator>Zhao, Feng-Chao</creator><creator>Guo, Kai-Jin</creator><creator>Li, Zi-Rong</creator><general>Springer Paris</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>201308</creationdate><title>Osteonecrosis of the femoral head in SARS patients: seven years later</title><author>Zhao, Feng-Chao ; Guo, Kai-Jin ; Li, Zi-Rong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3534-dc876ad8a13598d69c2294a03b057edc40cb23dd35b943609a4a6c18ac9fd94f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Bone Transplantation</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Femur Head Necrosis - chemically induced</topic><topic>Femur Head Necrosis - diagnosis</topic><topic>Femur Head Necrosis - surgery</topic><topic>Follow-Up Studies</topic><topic>Glucocorticoids - adverse effects</topic><topic>Hip Joint - pathology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Necrosis</topic><topic>Original Article</topic><topic>Pain - etiology</topic><topic>Prednisolone - adverse effects</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Severe Acute Respiratory Syndrome - complications</topic><topic>Steroids</topic><topic>Surgical Orthopedics</topic><topic>Traumatic Surgery</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Feng-Chao</creatorcontrib><creatorcontrib>Guo, Kai-Jin</creatorcontrib><creatorcontrib>Li, Zi-Rong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>European journal of orthopaedic surgery & traumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Feng-Chao</au><au>Guo, Kai-Jin</au><au>Li, Zi-Rong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Osteonecrosis of the femoral head in SARS patients: seven years later</atitle><jtitle>European journal of orthopaedic surgery & traumatology</jtitle><stitle>Eur J Orthop Surg Traumatol</stitle><addtitle>Eur J Orthop Surg Traumatol</addtitle><date>2013-08</date><risdate>2013</risdate><volume>23</volume><issue>6</issue><spage>671</spage><epage>677</epage><pages>671-677</pages><issn>1633-8065</issn><eissn>1432-1068</eissn><abstract>This study is aimed to explore the progression of osteonecrosis of the femoral head (OFNH) in severe acute respiratory syndrome patients 7 years after steroid administration and to analyze factors affecting the prognosis. One-hundred and ninety hips in 117 patients with more than 7 years of follow-up were studied. The prevalence of progression to symptoms and collapse was determined. The total dose of steroid, gender, age, stage, lesion location, volume of necrosis, viable lateral column and bone marrow edema were analyzed and correlated with progression. During the 7 years of follow-up, 66 hips progressed to symptoms, 50 hips collapsed and 10 hips showed complete regression. Fifty-seven hips (86.36 %) caused pain and 32 (64.00 %) collapsed within 3 years of steroid administration. The lesion was relatively larger, and there was relatively less viable lateral column in hips that exhibited symptoms or collapsed. Mechanical failure of the necrotic segment of bone principally occurred within 3 years after the administration of steroids. Larger lesions and less viable lateral column were the main risk factors for progression. Small ONFH lesions seldom collapsed.</abstract><cop>Paris</cop><pub>Springer Paris</pub><pmid>23412187</pmid><doi>10.1007/s00590-012-1054-4</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of orthopaedic surgery & traumatology, 2013-08, Vol.23 (6), p.671-677 |
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| subjects | Adult Bone Transplantation Disease Progression Female Femur Head Necrosis - chemically induced Femur Head Necrosis - diagnosis Femur Head Necrosis - surgery Follow-Up Studies Glucocorticoids - adverse effects Hip Joint - pathology Humans Magnetic Resonance Imaging Male Medicine Medicine & Public Health Middle Aged Necrosis Original Article Pain - etiology Prednisolone - adverse effects Prognosis Risk Factors Severe Acute Respiratory Syndrome - complications Steroids Surgical Orthopedics Traumatic Surgery Young Adult |
| title | Osteonecrosis of the femoral head in SARS patients: seven years later |
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