Enhanced brain delivery of hypoxia-sensitive liposomes by hydroxyurea for rescue therapy of hyperacute ischemic stroke

Ischemic stroke is characterized by high morbidity, disability, and mortality. Unfortunately, the only FDA-approved pharmacological thrombolytic, alteplase, has a narrow therapeutic window of only 4.5 h. Other drugs like neuroprotective agents have not been clinically used because of their low effic...

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Veröffentlicht in:	Nanoscale 2023-07, Vol.15 (27), p.11625-11646
Hauptverfasser:	Wang, Kai, Zhou, Wentao, Jin, Xiangyu, Shang, Xuwei, Wu, Xiaomei, Wen, Lijuan, Li, Sufen, Hong, Yiling, Ke, Jia, Xu, Yichong, Yuan, Hong, Hu, Fuqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood flow Blood-brain barrier Effectiveness Endothelial cells Hypoxia Liposomes Nitric oxide Permeability Stroke
Online-Zugang:	Volltext
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