Biomarkers and performance status as predictors of 30-day mortality in malignant spinal cord compression (MSCC) Patients
Introduction:Malignant spinal cord compression (MSCC) is a serious condition requiring urgent palliative radiotherapy to alleviate symptoms and avoid permanent paralysis. The aim of this project was to analyse the 30-day mortality rate post-palliative radiotherapy for MSCC patients to identify if ra...
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| Veröffentlicht in: | Journal of radiotherapy in practice 2022-03, Vol.21 (1), p.105-108 |
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| description | Introduction:Malignant spinal cord compression (MSCC) is a serious condition requiring urgent palliative radiotherapy to alleviate symptoms and avoid permanent paralysis. The aim of this project was to analyse the 30-day mortality rate post-palliative radiotherapy for MSCC patients to identify if radiotherapy can be safely omitted or the fractionation reduced in the poor prognosis group (patients likely to die within 30 days) by biomarkers and performance status (PS).Methods:A retrospective audit was performed (July–December 2019) and data on treatment duration, date of death, biomarkers (C-reactive protein (CRP), albumin) and PS were collected using hospital patient management systems.Results:Hundred and one patients received palliative radiotherapy for MSCC in the 6-month period. The number of patients who died within 30 days was 17, representing 16·8% mortality rate. Rising CRP levels and poor PS indicated a poorer prognosis in this patient group.Conclusion:Monitoring biomarkers and PS as standard throughout patients’ treatment is recommended to assess disease progression. Worsening PS and high CRP is an indicator of poor prognosis and early death, and therefore omission of treatment or a single fraction of radiotherapy is recommended. |
| doi_str_mv | 10.1017/S1460396920000989 |
| format | Article |
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The aim of this project was to analyse the 30-day mortality rate post-palliative radiotherapy for MSCC patients to identify if radiotherapy can be safely omitted or the fractionation reduced in the poor prognosis group (patients likely to die within 30 days) by biomarkers and performance status (PS).Methods:A retrospective audit was performed (July–December 2019) and data on treatment duration, date of death, biomarkers (C-reactive protein (CRP), albumin) and PS were collected using hospital patient management systems.Results:Hundred and one patients received palliative radiotherapy for MSCC in the 6-month period. The number of patients who died within 30 days was 17, representing 16·8% mortality rate. Rising CRP levels and poor PS indicated a poorer prognosis in this patient group.Conclusion:Monitoring biomarkers and PS as standard throughout patients’ treatment is recommended to assess disease progression. Worsening PS and high CRP is an indicator of poor prognosis and early death, and therefore omission of treatment or a single fraction of radiotherapy is recommended.</description><identifier>ISSN: 1460-3969</identifier><identifier>EISSN: 1467-1131</identifier><identifier>DOI: 10.1017/S1460396920000989</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Biomarkers ; C-reactive protein ; Cancer ; Compression ; Death ; Decision making ; Fecal incontinence ; Fractionation ; Management systems ; Medical prognosis ; Mortality ; Original Article ; Palliation ; Paralysis ; Patients ; Prognosis ; Quality improvement ; Radiation therapy ; Signs and symptoms ; Spinal cord</subject><ispartof>Journal of radiotherapy in practice, 2022-03, Vol.21 (1), p.105-108</ispartof><rights>The Author(s), 2020. Published by Cambridge University Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c269t-9c390eb7804c9a59944fcb6c947f837be88d4952a48c4c066ea9754538d51f023</cites><orcidid>0000-0002-1919-658X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S1460396920000989/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27903,27904,55606</link.rule.ids></links><search><creatorcontrib>Cameron, Josie</creatorcontrib><title>Biomarkers and performance status as predictors of 30-day mortality in malignant spinal cord compression (MSCC) Patients</title><title>Journal of radiotherapy in practice</title><addtitle>J Radiother Pract</addtitle><description>Introduction:Malignant spinal cord compression (MSCC) is a serious condition requiring urgent palliative radiotherapy to alleviate symptoms and avoid permanent paralysis. The aim of this project was to analyse the 30-day mortality rate post-palliative radiotherapy for MSCC patients to identify if radiotherapy can be safely omitted or the fractionation reduced in the poor prognosis group (patients likely to die within 30 days) by biomarkers and performance status (PS).Methods:A retrospective audit was performed (July–December 2019) and data on treatment duration, date of death, biomarkers (C-reactive protein (CRP), albumin) and PS were collected using hospital patient management systems.Results:Hundred and one patients received palliative radiotherapy for MSCC in the 6-month period. The number of patients who died within 30 days was 17, representing 16·8% mortality rate. Rising CRP levels and poor PS indicated a poorer prognosis in this patient group.Conclusion:Monitoring biomarkers and PS as standard throughout patients’ treatment is recommended to assess disease progression. Worsening PS and high CRP is an indicator of poor prognosis and early death, and therefore omission of treatment or a single fraction of radiotherapy is recommended.</description><subject>Biomarkers</subject><subject>C-reactive protein</subject><subject>Cancer</subject><subject>Compression</subject><subject>Death</subject><subject>Decision making</subject><subject>Fecal incontinence</subject><subject>Fractionation</subject><subject>Management systems</subject><subject>Medical prognosis</subject><subject>Mortality</subject><subject>Original Article</subject><subject>Palliation</subject><subject>Paralysis</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Quality improvement</subject><subject>Radiation therapy</subject><subject>Signs and symptoms</subject><subject>Spinal 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(MSCC) Patients</title><author>Cameron, Josie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c269t-9c390eb7804c9a59944fcb6c947f837be88d4952a48c4c066ea9754538d51f023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biomarkers</topic><topic>C-reactive protein</topic><topic>Cancer</topic><topic>Compression</topic><topic>Death</topic><topic>Decision making</topic><topic>Fecal incontinence</topic><topic>Fractionation</topic><topic>Management systems</topic><topic>Medical prognosis</topic><topic>Mortality</topic><topic>Original Article</topic><topic>Palliation</topic><topic>Paralysis</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Quality improvement</topic><topic>Radiation therapy</topic><topic>Signs and symptoms</topic><topic>Spinal cord</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cameron, 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Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Journal of radiotherapy in practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cameron, Josie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomarkers and performance status as predictors of 30-day mortality in malignant spinal cord compression (MSCC) Patients</atitle><jtitle>Journal of radiotherapy in practice</jtitle><addtitle>J Radiother Pract</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>21</volume><issue>1</issue><spage>105</spage><epage>108</epage><pages>105-108</pages><issn>1460-3969</issn><eissn>1467-1131</eissn><abstract>Introduction:Malignant spinal cord compression (MSCC) is a serious condition requiring urgent palliative radiotherapy to alleviate symptoms and avoid permanent paralysis. The aim of this project was to analyse the 30-day mortality rate post-palliative radiotherapy for MSCC patients to identify if radiotherapy can be safely omitted or the fractionation reduced in the poor prognosis group (patients likely to die within 30 days) by biomarkers and performance status (PS).Methods:A retrospective audit was performed (July–December 2019) and data on treatment duration, date of death, biomarkers (C-reactive protein (CRP), albumin) and PS were collected using hospital patient management systems.Results:Hundred and one patients received palliative radiotherapy for MSCC in the 6-month period. The number of patients who died within 30 days was 17, representing 16·8% mortality rate. Rising CRP levels and poor PS indicated a poorer prognosis in this patient group.Conclusion:Monitoring biomarkers and PS as standard throughout patients’ treatment is recommended to assess disease progression. Worsening PS and high CRP is an indicator of poor prognosis and early death, and therefore omission of treatment or a single fraction of radiotherapy is recommended.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><doi>10.1017/S1460396920000989</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-1919-658X</orcidid></addata></record> |
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| subjects | Biomarkers C-reactive protein Cancer Compression Death Decision making Fecal incontinence Fractionation Management systems Medical prognosis Mortality Original Article Palliation Paralysis Patients Prognosis Quality improvement Radiation therapy Signs and symptoms Spinal cord |
| title | Biomarkers and performance status as predictors of 30-day mortality in malignant spinal cord compression (MSCC) Patients |
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