254 The CBL-B inhibitor, NX-0255, enhances human drug enhanced tumor infiltrating lymphocyte (DeTIL) expansion and T cell function in full-scale runs

BackgroundEx-vivo expanded autologous tumor-infiltrating lymphocyte (TIL) therapy is one type of adoptive cellular therapy (ACT) which has demonstrated encouraging clinical responses in patients with melanoma or those with epithelial tumors. Effective methods to obtain sufficient TIL of suitable qua...

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Veröffentlicht in:	Journal for immunotherapy of cancer 2022-11, Vol.10 (Suppl 2), p.A269-A269
Hauptverfasser:	Liang, Xiaoyan, Wu, Xianzhu, Jeevitha Jeevan, Butler, Samuel, Murthy, Pranav, Sands, Arthur, Lotze, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Genotype & phenotype Immunotherapy Lymphocytes T cell receptors
Online-Zugang:	Volltext
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