253 Fully human CD123 CAR T cells irradicate AML in pre-clinical models and exhibit a favorable safety profile

BackgroundCD123, the interleukin-3 receptor alpha chain (IL-3Ra), is widely overexpressed in hematologic malignancies including acute myeloid leukemia (AML), at both the level of leukemic stem cells (LSCs) and leukemic blasts. This makes CD123 an attractive therapeutic target. Monoclonal antibodies...

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Veröffentlicht in:	Journal for immunotherapy of cancer 2022-11, Vol.10 (Suppl 2), p.A268-A268
Hauptverfasser:	Liang, Genqing, Hu, Peirong, Tran, Ngoc, Mahmud, Hasan, Dash, Pradyot, Schneider, Dina
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytokines Immunotherapy Leukemia Lymphocytes Stem cells
Online-Zugang:	Volltext
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