Quantitative susceptibility mapping of the normal-appearing white matter as a potential new marker of disability progression in multiple sclerosis
Objectives To investigate the normal-appearing white matter (NAWM) susceptibility in a cohort of newly diagnosed multiple sclerosis (MS) patients and to evaluate possible correlations between NAWM susceptibility and disability progression. Methods Fifty-nine patients with a diagnosis of MS ( n = 53)...
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| Veröffentlicht in: | European radiology 2023-08, Vol.33 (8), p.5368-5377 |
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| creator | Pietroboni, Anna M. Colombi, Annalisa Contarino, Valeria E. Russo, Francesco Maria Lo Conte, Giorgio Morabito, Aurelia Siggillino, Silvia Carandini, Tiziana Fenoglio, Chiara Arighi, Andrea De Riz, Milena A. Arcaro, Marina Sacchi, Luca Fumagalli, Giorgio G. Bianchi, Anna Maria Triulzi, Fabio Scarpini, Elio Galimberti, Daniela |
| description | Objectives
To investigate the normal-appearing white matter (NAWM) susceptibility in a cohort of newly diagnosed multiple sclerosis (MS) patients and to evaluate possible correlations between NAWM susceptibility and disability progression.
Methods
Fifty-nine patients with a diagnosis of MS (
n
= 53) or clinically isolated syndrome (CIS) (
n
= 6) were recruited and followed up. All participants underwent neurological examination, blood sampling for serum neurofilament light chain (sNfL) level assessment, lumbar puncture for the quantification of cerebrospinal fluid (CSF) β-amyloid
1-42
(Aβ) levels, and brain MRI. T2-weighted scans were used to quantify white matter (WM) lesion loads. For each scan, we derived the NAWM volume fraction and the WM lesion volume fraction. Quantitative susceptibility mapping (QSM) of the NAWM was calculated using the susceptibility tensor imaging (STI) suite. Susceptibility maps were computed with the STAR algorithm.
Results
Primary progressive patients (
n
= 9) showed a higher mean susceptibility value in the NAWM than relapsing-remitting (
n
= 44) and CIS (
n
= 6) (
p
= 0.01 and
p =
0.02). Patients with a higher susceptibility in the NAWM showed increased sNfL concentration (
ρ
= 0.38,
p
= 0.004) and lower CSF Aβ levels (
ρ
= −0.34,
p
= 0.009). Mean NAWM susceptibility turned out to be a predictor of the expanded disability status scale (EDSS) worsening at follow-up (
β
= 0.41,
t
= 2.66,
p
= 0.01) and of the MS severity scale (MSSS) (
β
= 0.38,
t
= 2.43,
p
= 0.019).
Conclusions
QSM in the NAWM seems to predict the EDSS increment over time. This finding might provide evidence on the role of QSM in identifying patients with an increased
risk
of early disability
progression
.
Key Points
•
NAWM-QSM is higher in PPMS patients than in RRMS.
•
NAWM-QSM seems to be a predictor of EDSS worsening over time.
•
Patients with higher NAWM-QSM show increased sNfL concentration and lower CSF Aβ levels. |
| doi_str_mv | 10.1007/s00330-022-09338-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2833800590</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2833800590</sourcerecordid><originalsourceid>FETCH-LOGICAL-c342t-67a151b6fcfb1ed0a54c73de416884c84ccbf0e6fa28b41e4ba00bac625757583</originalsourceid><addsrcrecordid>eNp9Udtq3DAQFSWl2aT9gT4EQZ6djC6WvY9hSdpCIBTaZyFrxxulXtuR5Cz7G_niznY3l6cigYaZc86M5jD2VcCFAKguE4BSUICUBcyVqgvzgc2EVrIQUOujd_ExO0npAQDmQlef2LEypZFVrWbs-efk-hyyy-EJeZqSxzGHJnQhb_najWPoV3xoeb5H3g9x7bqCkujiLr-5DxkJlTNG7hJ3fBwykpzreI8bqsQ_VCH6MiR3EB3jsIqYUhh6Hnq-nrocxo56-w7jkEL6zD62rkv45fCest83178W34vbu28_Fle3hVda5sJUTpSiMa1vG4FLcKX2lVqiFqautafrmxbQtE7WjRaoGwfQOG9kWdGp1Sk73-vSRI8Tpmwfhin21NLKmtYJUM6BUHKP8jRcitjaMQb62NYKsDsb7N4GSzbYfzZYQ6Szg_TUrHH5SnnZOwHUHpDG3SYxvvX-j-xfmvyXHA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2833800590</pqid></control><display><type>article</type><title>Quantitative susceptibility mapping of the normal-appearing white matter as a potential new marker of disability progression in multiple sclerosis</title><source>Springer Nature - Complete Springer Journals</source><creator>Pietroboni, Anna M. ; Colombi, Annalisa ; Contarino, Valeria E. ; Russo, Francesco Maria Lo ; Conte, Giorgio ; Morabito, Aurelia ; Siggillino, Silvia ; Carandini, Tiziana ; Fenoglio, Chiara ; Arighi, Andrea ; De Riz, Milena A. ; Arcaro, Marina ; Sacchi, Luca ; Fumagalli, Giorgio G. ; Bianchi, Anna Maria ; Triulzi, Fabio ; Scarpini, Elio ; Galimberti, Daniela</creator><creatorcontrib>Pietroboni, Anna M. ; Colombi, Annalisa ; Contarino, Valeria E. ; Russo, Francesco Maria Lo ; Conte, Giorgio ; Morabito, Aurelia ; Siggillino, Silvia ; Carandini, Tiziana ; Fenoglio, Chiara ; Arighi, Andrea ; De Riz, Milena A. ; Arcaro, Marina ; Sacchi, Luca ; Fumagalli, Giorgio G. ; Bianchi, Anna Maria ; Triulzi, Fabio ; Scarpini, Elio ; Galimberti, Daniela</creatorcontrib><description>Objectives
To investigate the normal-appearing white matter (NAWM) susceptibility in a cohort of newly diagnosed multiple sclerosis (MS) patients and to evaluate possible correlations between NAWM susceptibility and disability progression.
Methods
Fifty-nine patients with a diagnosis of MS (
n
= 53) or clinically isolated syndrome (CIS) (
n
= 6) were recruited and followed up. All participants underwent neurological examination, blood sampling for serum neurofilament light chain (sNfL) level assessment, lumbar puncture for the quantification of cerebrospinal fluid (CSF) β-amyloid
1-42
(Aβ) levels, and brain MRI. T2-weighted scans were used to quantify white matter (WM) lesion loads. For each scan, we derived the NAWM volume fraction and the WM lesion volume fraction. Quantitative susceptibility mapping (QSM) of the NAWM was calculated using the susceptibility tensor imaging (STI) suite. Susceptibility maps were computed with the STAR algorithm.
Results
Primary progressive patients (
n
= 9) showed a higher mean susceptibility value in the NAWM than relapsing-remitting (
n
= 44) and CIS (
n
= 6) (
p
= 0.01 and
p =
0.02). Patients with a higher susceptibility in the NAWM showed increased sNfL concentration (
ρ
= 0.38,
p
= 0.004) and lower CSF Aβ levels (
ρ
= −0.34,
p
= 0.009). Mean NAWM susceptibility turned out to be a predictor of the expanded disability status scale (EDSS) worsening at follow-up (
β
= 0.41,
t
= 2.66,
p
= 0.01) and of the MS severity scale (MSSS) (
β
= 0.38,
t
= 2.43,
p
= 0.019).
Conclusions
QSM in the NAWM seems to predict the EDSS increment over time. This finding might provide evidence on the role of QSM in identifying patients with an increased
risk
of early disability
progression
.
Key Points
•
NAWM-QSM is higher in PPMS patients than in RRMS.
•
NAWM-QSM seems to be a predictor of EDSS worsening over time.
•
Patients with higher NAWM-QSM show increased sNfL concentration and lower CSF Aβ levels.</description><identifier>ISSN: 1432-1084</identifier><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-022-09338-6</identifier><identifier>PMID: 36562783</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Algorithms ; Cerebrospinal fluid ; Diagnostic Radiology ; Imaging ; Internal Medicine ; Interventional Radiology ; Lesions ; Magnetic resonance imaging ; Mapping ; Medicine ; Medicine & Public Health ; Multiple sclerosis ; Neuro ; Neuroimaging ; Neuroradiology ; Radiology ; Substantia alba ; Susceptibility ; Tensors ; Ultrasound</subject><ispartof>European radiology, 2023-08, Vol.33 (8), p.5368-5377</ispartof><rights>The Author(s), under exclusive licence to European Society of Radiology 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to European Society of Radiology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-67a151b6fcfb1ed0a54c73de416884c84ccbf0e6fa28b41e4ba00bac625757583</citedby><cites>FETCH-LOGICAL-c342t-67a151b6fcfb1ed0a54c73de416884c84ccbf0e6fa28b41e4ba00bac625757583</cites><orcidid>0000-0003-1538-1830</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-022-09338-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-022-09338-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36562783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pietroboni, Anna M.</creatorcontrib><creatorcontrib>Colombi, Annalisa</creatorcontrib><creatorcontrib>Contarino, Valeria E.</creatorcontrib><creatorcontrib>Russo, Francesco Maria Lo</creatorcontrib><creatorcontrib>Conte, Giorgio</creatorcontrib><creatorcontrib>Morabito, Aurelia</creatorcontrib><creatorcontrib>Siggillino, Silvia</creatorcontrib><creatorcontrib>Carandini, Tiziana</creatorcontrib><creatorcontrib>Fenoglio, Chiara</creatorcontrib><creatorcontrib>Arighi, Andrea</creatorcontrib><creatorcontrib>De Riz, Milena A.</creatorcontrib><creatorcontrib>Arcaro, Marina</creatorcontrib><creatorcontrib>Sacchi, Luca</creatorcontrib><creatorcontrib>Fumagalli, Giorgio G.</creatorcontrib><creatorcontrib>Bianchi, Anna Maria</creatorcontrib><creatorcontrib>Triulzi, Fabio</creatorcontrib><creatorcontrib>Scarpini, Elio</creatorcontrib><creatorcontrib>Galimberti, Daniela</creatorcontrib><title>Quantitative susceptibility mapping of the normal-appearing white matter as a potential new marker of disability progression in multiple sclerosis</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objectives
To investigate the normal-appearing white matter (NAWM) susceptibility in a cohort of newly diagnosed multiple sclerosis (MS) patients and to evaluate possible correlations between NAWM susceptibility and disability progression.
Methods
Fifty-nine patients with a diagnosis of MS (
n
= 53) or clinically isolated syndrome (CIS) (
n
= 6) were recruited and followed up. All participants underwent neurological examination, blood sampling for serum neurofilament light chain (sNfL) level assessment, lumbar puncture for the quantification of cerebrospinal fluid (CSF) β-amyloid
1-42
(Aβ) levels, and brain MRI. T2-weighted scans were used to quantify white matter (WM) lesion loads. For each scan, we derived the NAWM volume fraction and the WM lesion volume fraction. Quantitative susceptibility mapping (QSM) of the NAWM was calculated using the susceptibility tensor imaging (STI) suite. Susceptibility maps were computed with the STAR algorithm.
Results
Primary progressive patients (
n
= 9) showed a higher mean susceptibility value in the NAWM than relapsing-remitting (
n
= 44) and CIS (
n
= 6) (
p
= 0.01 and
p =
0.02). Patients with a higher susceptibility in the NAWM showed increased sNfL concentration (
ρ
= 0.38,
p
= 0.004) and lower CSF Aβ levels (
ρ
= −0.34,
p
= 0.009). Mean NAWM susceptibility turned out to be a predictor of the expanded disability status scale (EDSS) worsening at follow-up (
β
= 0.41,
t
= 2.66,
p
= 0.01) and of the MS severity scale (MSSS) (
β
= 0.38,
t
= 2.43,
p
= 0.019).
Conclusions
QSM in the NAWM seems to predict the EDSS increment over time. This finding might provide evidence on the role of QSM in identifying patients with an increased
risk
of early disability
progression
.
Key Points
•
NAWM-QSM is higher in PPMS patients than in RRMS.
•
NAWM-QSM seems to be a predictor of EDSS worsening over time.
•
Patients with higher NAWM-QSM show increased sNfL concentration and lower CSF Aβ levels.</description><subject>Algorithms</subject><subject>Cerebrospinal fluid</subject><subject>Diagnostic Radiology</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Lesions</subject><subject>Magnetic resonance imaging</subject><subject>Mapping</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multiple sclerosis</subject><subject>Neuro</subject><subject>Neuroimaging</subject><subject>Neuroradiology</subject><subject>Radiology</subject><subject>Substantia alba</subject><subject>Susceptibility</subject><subject>Tensors</subject><subject>Ultrasound</subject><issn>1432-1084</issn><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9Udtq3DAQFSWl2aT9gT4EQZ6djC6WvY9hSdpCIBTaZyFrxxulXtuR5Cz7G_niznY3l6cigYaZc86M5jD2VcCFAKguE4BSUICUBcyVqgvzgc2EVrIQUOujd_ExO0npAQDmQlef2LEypZFVrWbs-efk-hyyy-EJeZqSxzGHJnQhb_najWPoV3xoeb5H3g9x7bqCkujiLr-5DxkJlTNG7hJ3fBwykpzreI8bqsQ_VCH6MiR3EB3jsIqYUhh6Hnq-nrocxo56-w7jkEL6zD62rkv45fCest83178W34vbu28_Fle3hVda5sJUTpSiMa1vG4FLcKX2lVqiFqautafrmxbQtE7WjRaoGwfQOG9kWdGp1Sk73-vSRI8Tpmwfhin21NLKmtYJUM6BUHKP8jRcitjaMQb62NYKsDsb7N4GSzbYfzZYQ6Szg_TUrHH5SnnZOwHUHpDG3SYxvvX-j-xfmvyXHA</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Pietroboni, Anna M.</creator><creator>Colombi, Annalisa</creator><creator>Contarino, Valeria E.</creator><creator>Russo, Francesco Maria Lo</creator><creator>Conte, Giorgio</creator><creator>Morabito, Aurelia</creator><creator>Siggillino, Silvia</creator><creator>Carandini, Tiziana</creator><creator>Fenoglio, Chiara</creator><creator>Arighi, Andrea</creator><creator>De Riz, Milena A.</creator><creator>Arcaro, Marina</creator><creator>Sacchi, Luca</creator><creator>Fumagalli, Giorgio G.</creator><creator>Bianchi, Anna Maria</creator><creator>Triulzi, Fabio</creator><creator>Scarpini, Elio</creator><creator>Galimberti, Daniela</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><orcidid>https://orcid.org/0000-0003-1538-1830</orcidid></search><sort><creationdate>20230801</creationdate><title>Quantitative susceptibility mapping of the normal-appearing white matter as a potential new marker of disability progression in multiple sclerosis</title><author>Pietroboni, Anna M. ; Colombi, Annalisa ; Contarino, Valeria E. ; Russo, Francesco Maria Lo ; Conte, Giorgio ; Morabito, Aurelia ; Siggillino, Silvia ; Carandini, Tiziana ; Fenoglio, Chiara ; Arighi, Andrea ; De Riz, Milena A. ; Arcaro, Marina ; Sacchi, Luca ; Fumagalli, Giorgio G. ; Bianchi, Anna Maria ; Triulzi, Fabio ; Scarpini, Elio ; Galimberti, Daniela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-67a151b6fcfb1ed0a54c73de416884c84ccbf0e6fa28b41e4ba00bac625757583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Algorithms</topic><topic>Cerebrospinal fluid</topic><topic>Diagnostic Radiology</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Lesions</topic><topic>Magnetic resonance imaging</topic><topic>Mapping</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multiple sclerosis</topic><topic>Neuro</topic><topic>Neuroimaging</topic><topic>Neuroradiology</topic><topic>Radiology</topic><topic>Substantia alba</topic><topic>Susceptibility</topic><topic>Tensors</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pietroboni, Anna M.</creatorcontrib><creatorcontrib>Colombi, Annalisa</creatorcontrib><creatorcontrib>Contarino, Valeria E.</creatorcontrib><creatorcontrib>Russo, Francesco Maria Lo</creatorcontrib><creatorcontrib>Conte, Giorgio</creatorcontrib><creatorcontrib>Morabito, Aurelia</creatorcontrib><creatorcontrib>Siggillino, Silvia</creatorcontrib><creatorcontrib>Carandini, Tiziana</creatorcontrib><creatorcontrib>Fenoglio, Chiara</creatorcontrib><creatorcontrib>Arighi, Andrea</creatorcontrib><creatorcontrib>De Riz, Milena A.</creatorcontrib><creatorcontrib>Arcaro, Marina</creatorcontrib><creatorcontrib>Sacchi, Luca</creatorcontrib><creatorcontrib>Fumagalli, Giorgio G.</creatorcontrib><creatorcontrib>Bianchi, Anna Maria</creatorcontrib><creatorcontrib>Triulzi, Fabio</creatorcontrib><creatorcontrib>Scarpini, Elio</creatorcontrib><creatorcontrib>Galimberti, Daniela</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pietroboni, Anna M.</au><au>Colombi, Annalisa</au><au>Contarino, Valeria E.</au><au>Russo, Francesco Maria Lo</au><au>Conte, Giorgio</au><au>Morabito, Aurelia</au><au>Siggillino, Silvia</au><au>Carandini, Tiziana</au><au>Fenoglio, Chiara</au><au>Arighi, Andrea</au><au>De Riz, Milena A.</au><au>Arcaro, Marina</au><au>Sacchi, Luca</au><au>Fumagalli, Giorgio G.</au><au>Bianchi, Anna Maria</au><au>Triulzi, Fabio</au><au>Scarpini, Elio</au><au>Galimberti, Daniela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative susceptibility mapping of the normal-appearing white matter as a potential new marker of disability progression in multiple sclerosis</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>33</volume><issue>8</issue><spage>5368</spage><epage>5377</epage><pages>5368-5377</pages><issn>1432-1084</issn><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objectives
To investigate the normal-appearing white matter (NAWM) susceptibility in a cohort of newly diagnosed multiple sclerosis (MS) patients and to evaluate possible correlations between NAWM susceptibility and disability progression.
Methods
Fifty-nine patients with a diagnosis of MS (
n
= 53) or clinically isolated syndrome (CIS) (
n
= 6) were recruited and followed up. All participants underwent neurological examination, blood sampling for serum neurofilament light chain (sNfL) level assessment, lumbar puncture for the quantification of cerebrospinal fluid (CSF) β-amyloid
1-42
(Aβ) levels, and brain MRI. T2-weighted scans were used to quantify white matter (WM) lesion loads. For each scan, we derived the NAWM volume fraction and the WM lesion volume fraction. Quantitative susceptibility mapping (QSM) of the NAWM was calculated using the susceptibility tensor imaging (STI) suite. Susceptibility maps were computed with the STAR algorithm.
Results
Primary progressive patients (
n
= 9) showed a higher mean susceptibility value in the NAWM than relapsing-remitting (
n
= 44) and CIS (
n
= 6) (
p
= 0.01 and
p =
0.02). Patients with a higher susceptibility in the NAWM showed increased sNfL concentration (
ρ
= 0.38,
p
= 0.004) and lower CSF Aβ levels (
ρ
= −0.34,
p
= 0.009). Mean NAWM susceptibility turned out to be a predictor of the expanded disability status scale (EDSS) worsening at follow-up (
β
= 0.41,
t
= 2.66,
p
= 0.01) and of the MS severity scale (MSSS) (
β
= 0.38,
t
= 2.43,
p
= 0.019).
Conclusions
QSM in the NAWM seems to predict the EDSS increment over time. This finding might provide evidence on the role of QSM in identifying patients with an increased
risk
of early disability
progression
.
Key Points
•
NAWM-QSM is higher in PPMS patients than in RRMS.
•
NAWM-QSM seems to be a predictor of EDSS worsening over time.
•
Patients with higher NAWM-QSM show increased sNfL concentration and lower CSF Aβ levels.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>36562783</pmid><doi>10.1007/s00330-022-09338-6</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-1538-1830</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1432-1084 |
| ispartof | European radiology, 2023-08, Vol.33 (8), p.5368-5377 |
| issn | 1432-1084 0938-7994 1432-1084 |
| language | eng |
| recordid | cdi_proquest_journals_2833800590 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Algorithms Cerebrospinal fluid Diagnostic Radiology Imaging Internal Medicine Interventional Radiology Lesions Magnetic resonance imaging Mapping Medicine Medicine & Public Health Multiple sclerosis Neuro Neuroimaging Neuroradiology Radiology Substantia alba Susceptibility Tensors Ultrasound |
| title | Quantitative susceptibility mapping of the normal-appearing white matter as a potential new marker of disability progression in multiple sclerosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T18%3A20%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Quantitative%20susceptibility%20mapping%20of%20the%20normal-appearing%20white%20matter%20as%20a%20potential%20new%20marker%20of%20disability%20progression%20in%20multiple%20sclerosis&rft.jtitle=European%20radiology&rft.au=Pietroboni,%20Anna%20M.&rft.date=2023-08-01&rft.volume=33&rft.issue=8&rft.spage=5368&rft.epage=5377&rft.pages=5368-5377&rft.issn=1432-1084&rft.eissn=1432-1084&rft_id=info:doi/10.1007/s00330-022-09338-6&rft_dat=%3Cproquest_cross%3E2833800590%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2833800590&rft_id=info:pmid/36562783&rfr_iscdi=true |