Predicting transporter mediated drug–drug interactions via static and dynamic physiologically based pharmacokinetic modeling: A comprehensive insight on where we are now and the way forward

The greater utilization and acceptance of physiologically‐based pharmacokinetic (PBPK) modeling to evaluate the potential metabolic drug–drug interactions is evident by the plethora of literature, guidance's, and regulatory dossiers available in the literature. In contrast, it is not widely use...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biopharmaceutics & drug disposition 2023-06, Vol.44 (3), p.195-220
Hauptverfasser:	Vijaywargi, Gautam, Kollipara, Sivacharan, Ahmed, Tausif, Chachad, Siddharth
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug interaction Drug interactions Enzymes Geriatrics IVIVE PBPK modeling Pediatrics Pharmacokinetics Predictions regulatory special population transporter‐mediated drug–drug interactions
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!