Prospects for Infrared Luminescent Diagnostics of Superficially Located Neoplasms Using Ytterbium Porphyrin Complexes
In this paper, we developed a promising technique for luminescent infrared (IR) diagnostics of neoplasms of visually and endoscopically accessible localization (dermatology, gynecology, dentistry) using ytterbium complexes of porphyrins. Possible mechanisms of accumulation of a pharmaceutical compos...
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| Veröffentlicht in: | Journal of communications technology & electronics 2023-04, Vol.68 (4), p.474-480 |
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| creator | Shilov, I. P. Rumyantseva, V. D. Ivanov, A. V. Alekseev, Yu. V. Gorshkova, A. S. Ryabov, M. V. Kovaleva, A. M. Kovalev, M. I. |
| description | In this paper, we developed a promising technique for luminescent infrared (IR) diagnostics of neoplasms of visually and endoscopically accessible localization (dermatology, gynecology, dentistry) using ytterbium complexes of porphyrins. Possible mechanisms of accumulation of a pharmaceutical composition based on the ytterbium complex of 2,4-di(α-methoxyethyl)deuteroporphyrin IX (Yb-DMDP) in tumor tissues were studied. Studies on the pharmacokinetics and biodistribution of this substance in various organs and neoplasms of laboratory animals showed a significant selectivity of the accumulation of nanoparticles with ytterbium ions in tumors as early as 24 h after intravenous administration. For the purposes of luminescent IR diagnostics, a highly sensitive laser-fiber fluorimeter operating in the spectral range of 900–1100 nm was developed. Preclinical tests of the developed method of fluorescent IR cancer diagnostics were carried out and its prospects were shown. |
| doi_str_mv | 10.1134/S1064226923030130 |
| format | Article |
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P. ; Rumyantseva, V. D. ; Ivanov, A. V. ; Alekseev, Yu. V. ; Gorshkova, A. S. ; Ryabov, M. V. ; Kovaleva, A. M. ; Kovalev, M. I.</creator><creatorcontrib>Shilov, I. P. ; Rumyantseva, V. D. ; Ivanov, A. V. ; Alekseev, Yu. V. ; Gorshkova, A. S. ; Ryabov, M. V. ; Kovaleva, A. M. ; Kovalev, M. I.</creatorcontrib><description>In this paper, we developed a promising technique for luminescent infrared (IR) diagnostics of neoplasms of visually and endoscopically accessible localization (dermatology, gynecology, dentistry) using ytterbium complexes of porphyrins. Possible mechanisms of accumulation of a pharmaceutical composition based on the ytterbium complex of 2,4-di(α-methoxyethyl)deuteroporphyrin IX (Yb-DMDP) in tumor tissues were studied. Studies on the pharmacokinetics and biodistribution of this substance in various organs and neoplasms of laboratory animals showed a significant selectivity of the accumulation of nanoparticles with ytterbium ions in tumors as early as 24 h after intravenous administration. For the purposes of luminescent IR diagnostics, a highly sensitive laser-fiber fluorimeter operating in the spectral range of 900–1100 nm was developed. Preclinical tests of the developed method of fluorescent IR cancer diagnostics were carried out and its prospects were shown.</description><identifier>ISSN: 1064-2269</identifier><identifier>EISSN: 1555-6557</identifier><identifier>DOI: 10.1134/S1064226923030130</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Accumulation ; Applications of Radiotechnology and Electronics in Biology and Medicine ; Communications Engineering ; Dermatology ; Engineering ; Fluorescence ; Fluorometers ; Gynecology ; Laboratory animals ; Nanoparticles ; Neoplasms ; Networks ; Porphyrins ; Tumors ; Ytterbium</subject><ispartof>Journal of communications technology & electronics, 2023-04, Vol.68 (4), p.474-480</ispartof><rights>Pleiades Publishing, Inc. 2023. ISSN 1064-2269, Journal of Communications Technology and Electronics, 2023, Vol. 68, No. 4, pp. 474–480. © Pleiades Publishing, Inc., 2023. Russian Text © The Author(s), 2023, published in Radiotekhnika i Elektronika, 2023, Vol. 68, No. 4, pp. 399–406.</rights><rights>COPYRIGHT 2023 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c406t-134dda7eabd668fa1cb9562b7e214540e0d05d47679c861abf3a3b72351108e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1064226923030130$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1064226923030130$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids></links><search><creatorcontrib>Shilov, I. P.</creatorcontrib><creatorcontrib>Rumyantseva, V. D.</creatorcontrib><creatorcontrib>Ivanov, A. V.</creatorcontrib><creatorcontrib>Alekseev, Yu. 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Studies on the pharmacokinetics and biodistribution of this substance in various organs and neoplasms of laboratory animals showed a significant selectivity of the accumulation of nanoparticles with ytterbium ions in tumors as early as 24 h after intravenous administration. For the purposes of luminescent IR diagnostics, a highly sensitive laser-fiber fluorimeter operating in the spectral range of 900–1100 nm was developed. Preclinical tests of the developed method of fluorescent IR cancer diagnostics were carried out and its prospects were shown.</description><subject>Accumulation</subject><subject>Applications of Radiotechnology and Electronics in Biology and Medicine</subject><subject>Communications Engineering</subject><subject>Dermatology</subject><subject>Engineering</subject><subject>Fluorescence</subject><subject>Fluorometers</subject><subject>Gynecology</subject><subject>Laboratory animals</subject><subject>Nanoparticles</subject><subject>Neoplasms</subject><subject>Networks</subject><subject>Porphyrins</subject><subject>Tumors</subject><subject>Ytterbium</subject><issn>1064-2269</issn><issn>1555-6557</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>N95</sourceid><recordid>eNp1klFr1TAUgIsobE5_wN4CPgl2Jk2Tto_jOvXCRceue_CppOlJl9EmNSeF3X9vLnc4LzoCScj5vhNycrLsnNELxnj5ccuoLItCNgWnnDJOX2SnTAiRSyGql2mfwvk-fpK9RrynlDeS8tNsuQ4eZ9ARifGBrJ0JKkBPNstkHaAGF8knqwbnMVqNxBuyXWYIxmqrxnFHNl6rmIRv4OdR4YTkFq0byM8YIXR2mci1D_PdLlhHVn6aR3gAfJO9MmpEePu4nmW3n69-rL7mm-9f1qvLTa5LKmOeHtb3qgLV9VLWRjHdNUIWXQUFK0VJgfZU9GUlq0bXkqnOcMW7quCCMVqD4GfZu0PeOfhfC2Bs7_0SXLqyLeqirutmX4U_1KBGaK0zPgalJ4u6vaxEyWktGE_UxX-oNHqYrPYOjE3nR8L7IyExER7ioBbEdr29OWY__MV2C-6Lnya0w13Eg3KEswOu0-9hANPOwU4q7FpG230_tP_0Q3KKg4OJdQOEp1o8L_0GVKK1yQ</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Shilov, I. 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| subjects | Accumulation Applications of Radiotechnology and Electronics in Biology and Medicine Communications Engineering Dermatology Engineering Fluorescence Fluorometers Gynecology Laboratory animals Nanoparticles Neoplasms Networks Porphyrins Tumors Ytterbium |
| title | Prospects for Infrared Luminescent Diagnostics of Superficially Located Neoplasms Using Ytterbium Porphyrin Complexes |
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