Nebivolol Alleviates Vascular Endothelial Insulin Resistance by Inhibiting Endoplasmic Reticulum Stress

Vascular endothelial insulin resistance (IR) is an important risk factor in the development of vascular complications in diabetes. Prolonged endoplasmic reticulum stress (ERS) contributes to the development and progression of endothelial IR. The current study assessed the effects and mechanism of ne...

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Veröffentlicht in:	International Heart Journal 2023/03/31, Vol.64(2), pp.283-293
Hauptverfasser:	Li, Xinxin, Li, Qiuping, Wu, Lijun, Wang, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Aorta Diabetes mellitus Dyslipidemia Endoplasmic reticulum Endoplasmic Reticulum Stress Endothelial cells Endothelial Cells - metabolism GK rats Glucose HAECs Homeostasis Humans Hyperglycemia Immunoglobulins Insulin - pharmacology Insulin receptor substrate 1 Insulin Resistance IRS-1/PI3K/Akt/eNOS Metabolic disorders Nebivolol - pharmacology Nebivolol - therapeutic use Nitric oxide Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Wistar Risk factors TUDCA Tunicamycin Vasodilation
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