Inactivation of mitochondrial pyruvate carrier promotes NLRP3 inflammasome activation and gout development via metabolic reprogramming

The nucleotide‐binding and oligomerization domain, leucine‐rich repeats, and pyrin domain‐containing protein 3 (NLRP3) inflammasome plays a crucial role in innate immunity and is involved in the pathogenesis of autoinflammatory diseases. Glycolysis regulates NLRP3 inflammasome activation in macropha...

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Veröffentlicht in:	Immunology 2023-07, Vol.169 (3), p.271-291
Hauptverfasser:	Chen, Lih‐Chyang, Chen, Yu‐Jen, Lin, Hsin‐An, Chien, Wu‐Chien, Tsai, Kuen‐Jou, Chung, Chi‐Hsiang, Wang, Jui‐Yang, Chen, Chien‐Chou, Liao, Nan‐Shih, Shih, Chieh‐Tien, Lin, Yi‐Ying, Huang, Chi‐Ning, Ojcius, David M., Huang, Kuo‐Yang, Lin, Hsin‐Chung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphate Cell activation Crystals Deactivation Diabetes Diabetes mellitus Fermentation Glycolysis Gout Inactivation Inflammasomes Inflammatory diseases Innate immunity Insulin Lactic acid Leucine Macrophages Mitochondria mitochondrial pyruvate carrier NLRP3 inflammasome Nucleotides Oligomerization Oxidation Oxygen consumption Pathogenesis Peritonitis Pioglitazone Pyrin protein Pyruvic acid Uric acid
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