A Reappraisal of Superficial Pleomorphic Liposarcoma: Exploring the Relationship to Atypical Spindle Cell/ Pleomorphic Lipomatous Tumor
Objectives: Superficial pleomorphic liposarcoma (PL) has a favorable prognosis compared to deeply seated PL. Given developments in the classification of lipomatous neoplasms, we reappraised a series of cases. Methods: Retrospective clinicopathologic evaluation and genome-wide single-nucleotide polym...
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| Veröffentlicht in: | American journal of clinical pathology 2020-09, Vol.154 (3), p.353-361 |
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| creator | Berg, Scott Hilliard Massoud, Cathy Meade Jackson-Cook, Colleen Boikos, Sosipatros Alexander Smith, Steven Christopher Mochel, Mark Cameron |
| description | Objectives: Superficial pleomorphic liposarcoma (PL) has a favorable prognosis compared to deeply seated PL. Given developments in the classification of lipomatous neoplasms, we reappraised a series of cases. Methods: Retrospective clinicopathologic evaluation and genome-wide single-nucleotide polymorphism (SNP) microarray studies were performed for cases previously designated superficial PL. Results: Four cases were identified (age, 48-70 years). Two were dermally confined, whereas two were superficial subcutaneous; no recurrences or metastases were reported. Tumors demonstrated pleomorphic spindled morphology with variable cellularity. Multivacuolated atypical lipoblasts were focal in 3 and abundant in 1. Dermal tumors demonstrated atypical cells within sclerotic collagen. Genome-wide SNP microarray studies revealed consistent gains and losses, including losses at the 13q14.2 locus encompassing RBI and DLEU2 and deletion/disruption of the TP53 locus. Although subcutaneous examples showed genomic changes similar to deep PL, the dermal examples showed fewer genetic alterations, including changes reported in the spectrum of atypical spindle cell/pleomorphic lipomatous tumors (ASPLT). All lacked MDM2 amplification. Conclusions: Careful integration of histologic and genetic features may improve classification of lipomatous neoplasms with atypia, allowing reclassification of some superficial PL as ASPLT. Key Words: Liposarcoma; Atypical lipomatous tumor; Spindle cell lipoma; Pleomorphic lipoma |
| doi_str_mv | 10.1093/AJCP/AQAA045 |
| format | Article |
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Given developments in the classification of lipomatous neoplasms, we reappraised a series of cases. Methods: Retrospective clinicopathologic evaluation and genome-wide single-nucleotide polymorphism (SNP) microarray studies were performed for cases previously designated superficial PL. Results: Four cases were identified (age, 48-70 years). Two were dermally confined, whereas two were superficial subcutaneous; no recurrences or metastases were reported. Tumors demonstrated pleomorphic spindled morphology with variable cellularity. Multivacuolated atypical lipoblasts were focal in 3 and abundant in 1. Dermal tumors demonstrated atypical cells within sclerotic collagen. Genome-wide SNP microarray studies revealed consistent gains and losses, including losses at the 13q14.2 locus encompassing RBI and DLEU2 and deletion/disruption of the TP53 locus. Although subcutaneous examples showed genomic changes similar to deep PL, the dermal examples showed fewer genetic alterations, including changes reported in the spectrum of atypical spindle cell/pleomorphic lipomatous tumors (ASPLT). All lacked MDM2 amplification. Conclusions: Careful integration of histologic and genetic features may improve classification of lipomatous neoplasms with atypia, allowing reclassification of some superficial PL as ASPLT. Key Words: Liposarcoma; Atypical lipomatous tumor; Spindle cell lipoma; Pleomorphic lipoma</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1093/AJCP/AQAA045</identifier><language>eng</language><publisher>Chicago: Oxford University Press</publisher><subject>Chromosome 13 ; Collagen ; Comparative analysis ; Gene deletion ; Genomes ; Genomics ; Liposarcoma ; MDM2 protein ; Metastases ; Metastasis ; p53 Protein ; Prognosis ; Reclassification ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Tumor proteins ; Tumors</subject><ispartof>American journal of clinical pathology, 2020-09, Vol.154 (3), p.353-361</ispartof><rights>COPYRIGHT 2020 Oxford University Press</rights><rights>American Society for Clinical Pathology, 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Berg, Scott Hilliard</creatorcontrib><creatorcontrib>Massoud, Cathy Meade</creatorcontrib><creatorcontrib>Jackson-Cook, Colleen</creatorcontrib><creatorcontrib>Boikos, Sosipatros Alexander</creatorcontrib><creatorcontrib>Smith, Steven Christopher</creatorcontrib><creatorcontrib>Mochel, Mark Cameron</creatorcontrib><title>A Reappraisal of Superficial Pleomorphic Liposarcoma: Exploring the Relationship to Atypical Spindle Cell/ Pleomorphic Lipomatous Tumor</title><title>American journal of clinical pathology</title><description>Objectives: Superficial pleomorphic liposarcoma (PL) has a favorable prognosis compared to deeply seated PL. Given developments in the classification of lipomatous neoplasms, we reappraised a series of cases. Methods: Retrospective clinicopathologic evaluation and genome-wide single-nucleotide polymorphism (SNP) microarray studies were performed for cases previously designated superficial PL. Results: Four cases were identified (age, 48-70 years). Two were dermally confined, whereas two were superficial subcutaneous; no recurrences or metastases were reported. Tumors demonstrated pleomorphic spindled morphology with variable cellularity. Multivacuolated atypical lipoblasts were focal in 3 and abundant in 1. Dermal tumors demonstrated atypical cells within sclerotic collagen. Genome-wide SNP microarray studies revealed consistent gains and losses, including losses at the 13q14.2 locus encompassing RBI and DLEU2 and deletion/disruption of the TP53 locus. Although subcutaneous examples showed genomic changes similar to deep PL, the dermal examples showed fewer genetic alterations, including changes reported in the spectrum of atypical spindle cell/pleomorphic lipomatous tumors (ASPLT). All lacked MDM2 amplification. Conclusions: Careful integration of histologic and genetic features may improve classification of lipomatous neoplasms with atypia, allowing reclassification of some superficial PL as ASPLT. Key Words: Liposarcoma; Atypical lipomatous tumor; Spindle cell lipoma; Pleomorphic lipoma</description><subject>Chromosome 13</subject><subject>Collagen</subject><subject>Comparative analysis</subject><subject>Gene deletion</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Liposarcoma</subject><subject>MDM2 protein</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>p53 Protein</subject><subject>Prognosis</subject><subject>Reclassification</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><subject>Tumor proteins</subject><subject>Tumors</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptjV1LwzAUhoMoOKd3_oCA192StF1a78qYXwycbl6P0_R0y0ib2LSgv8C_bUBBQTkXh_PyvM8h5JKzCWd5PC0e5qtp8VQULEmPyIjnSRxJKcQxGTHGRJRzGZ-SM-8PjHGRsWREPgr6jOBcB9qDobam68FhV2ulw7kyaBvbub1WdKmd9dAp28A1Xbw5Yzvd7mi_x2Aw0Gvb-r12tLe06N-dVqG_drqtDNI5GjP9Y2ugt4OnmyGE5-SkBuPx4nuPycvNYjO_i5aPt_fzYhnteMb6SJYSsxlAHNdY1iUyOUtDJBIOoqokYA04K9My4TwpqwywKjOpIEXgUnHG4zG5-vK6zr4O6PvtwQ5dG15uRSbiTORpFv9QOzC41W1t-w5Uo73aFpLxJJd8JgM1-YcKU2GjlW2x1iH_VfgE35KCOQ</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Berg, Scott Hilliard</creator><creator>Massoud, Cathy Meade</creator><creator>Jackson-Cook, Colleen</creator><creator>Boikos, Sosipatros Alexander</creator><creator>Smith, Steven Christopher</creator><creator>Mochel, Mark Cameron</creator><general>Oxford University Press</general><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20200901</creationdate><title>A Reappraisal of Superficial Pleomorphic Liposarcoma: Exploring the Relationship to Atypical Spindle Cell/ Pleomorphic Lipomatous Tumor</title><author>Berg, Scott Hilliard ; Massoud, Cathy Meade ; Jackson-Cook, Colleen ; Boikos, Sosipatros Alexander ; Smith, Steven Christopher ; Mochel, Mark Cameron</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g180t-7b7e86aa33febfbe0765b7e241a2dd7aefae6b5b4114bd8aedb87ca5ea17c1013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Chromosome 13</topic><topic>Collagen</topic><topic>Comparative analysis</topic><topic>Gene deletion</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Liposarcoma</topic><topic>MDM2 protein</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>p53 Protein</topic><topic>Prognosis</topic><topic>Reclassification</topic><topic>Single nucleotide polymorphisms</topic><topic>Single-nucleotide polymorphism</topic><topic>Tumor proteins</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berg, Scott Hilliard</creatorcontrib><creatorcontrib>Massoud, Cathy Meade</creatorcontrib><creatorcontrib>Jackson-Cook, Colleen</creatorcontrib><creatorcontrib>Boikos, Sosipatros Alexander</creatorcontrib><creatorcontrib>Smith, Steven Christopher</creatorcontrib><creatorcontrib>Mochel, Mark Cameron</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berg, Scott Hilliard</au><au>Massoud, Cathy Meade</au><au>Jackson-Cook, Colleen</au><au>Boikos, Sosipatros Alexander</au><au>Smith, Steven Christopher</au><au>Mochel, Mark Cameron</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Reappraisal of Superficial Pleomorphic Liposarcoma: Exploring the Relationship to Atypical Spindle Cell/ Pleomorphic Lipomatous Tumor</atitle><jtitle>American journal of clinical pathology</jtitle><date>2020-09-01</date><risdate>2020</risdate><volume>154</volume><issue>3</issue><spage>353</spage><epage>361</epage><pages>353-361</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><abstract>Objectives: Superficial pleomorphic liposarcoma (PL) has a favorable prognosis compared to deeply seated PL. Given developments in the classification of lipomatous neoplasms, we reappraised a series of cases. Methods: Retrospective clinicopathologic evaluation and genome-wide single-nucleotide polymorphism (SNP) microarray studies were performed for cases previously designated superficial PL. Results: Four cases were identified (age, 48-70 years). Two were dermally confined, whereas two were superficial subcutaneous; no recurrences or metastases were reported. Tumors demonstrated pleomorphic spindled morphology with variable cellularity. Multivacuolated atypical lipoblasts were focal in 3 and abundant in 1. Dermal tumors demonstrated atypical cells within sclerotic collagen. Genome-wide SNP microarray studies revealed consistent gains and losses, including losses at the 13q14.2 locus encompassing RBI and DLEU2 and deletion/disruption of the TP53 locus. Although subcutaneous examples showed genomic changes similar to deep PL, the dermal examples showed fewer genetic alterations, including changes reported in the spectrum of atypical spindle cell/pleomorphic lipomatous tumors (ASPLT). All lacked MDM2 amplification. Conclusions: Careful integration of histologic and genetic features may improve classification of lipomatous neoplasms with atypia, allowing reclassification of some superficial PL as ASPLT. Key Words: Liposarcoma; Atypical lipomatous tumor; Spindle cell lipoma; Pleomorphic lipoma</abstract><cop>Chicago</cop><pub>Oxford University Press</pub><doi>10.1093/AJCP/AQAA045</doi><tpages>9</tpages></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Chromosome 13 Collagen Comparative analysis Gene deletion Genomes Genomics Liposarcoma MDM2 protein Metastases Metastasis p53 Protein Prognosis Reclassification Single nucleotide polymorphisms Single-nucleotide polymorphism Tumor proteins Tumors |
| title | A Reappraisal of Superficial Pleomorphic Liposarcoma: Exploring the Relationship to Atypical Spindle Cell/ Pleomorphic Lipomatous Tumor |
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