A coumarin-pyrazole-based probe for the fluorescence detection of phosgene with high selectivity and sensitivity
The high toxicity of phosgene poses potential threats to public health and safety. In this work, a novel fluorescent probe was designed to detect phosgene using hydroxyl and pyrazole moieties as the recognition sites. The response to phosgene with probe 1 was fast (less than 30 s), highly selective...
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| Veröffentlicht in: | Analytical methods 2023-06, Vol.15 (22), p.2761-2765 |
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| container_title | Analytical methods |
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| creator | Hu, Qiang Song, Yu-Fei Wu, Wei-Na Zhao, Xiao-Lei Wang, Yuan Fan, Yun-Chang |
| description | The high toxicity of phosgene poses potential threats to public health and safety. In this work, a novel fluorescent probe was designed to detect phosgene using hydroxyl and pyrazole moieties as the recognition sites. The response to phosgene with probe
1
was fast (less than 30 s), highly selective and sensitive with the limit of detection being 4.78 nM in solution. Furthermore, probe
1
was employed to conveniently fabricate paper test strips for efficiently detecting phosgene gas. The limit of detection was obtained as 0.014 ppm by using a smartphone RGB app, revealing that probe
1
has good prospects for sensitively detecting phosgene gas.
In this study, we reported a coumarin-pyrazole-based probe for the fluorescence detection of phosgene. Probe
1
responded rapidly to phosgene with good selectivity and high sensitivity, especially for phosgene gas-phase detection. |
| doi_str_mv | 10.1039/d3ay00516j |
| format | Article |
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1
was fast (less than 30 s), highly selective and sensitive with the limit of detection being 4.78 nM in solution. Furthermore, probe
1
was employed to conveniently fabricate paper test strips for efficiently detecting phosgene gas. The limit of detection was obtained as 0.014 ppm by using a smartphone RGB app, revealing that probe
1
has good prospects for sensitively detecting phosgene gas.
In this study, we reported a coumarin-pyrazole-based probe for the fluorescence detection of phosgene. Probe
1
responded rapidly to phosgene with good selectivity and high sensitivity, especially for phosgene gas-phase detection.</description><identifier>ISSN: 1759-9660</identifier><identifier>EISSN: 1759-9679</identifier><identifier>DOI: 10.1039/d3ay00516j</identifier><identifier>PMID: 37255236</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Coumarin ; Coumarins ; Fluorescence ; Fluorescent Dyes ; Fluorescent indicators ; Phosgene ; Public health ; Pyrazole ; Pyrazoles ; Spectrometry, Fluorescence ; Toxicity</subject><ispartof>Analytical methods, 2023-06, Vol.15 (22), p.2761-2765</ispartof><rights>Copyright Royal Society of Chemistry 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-b917bdc4029326359e0f4a0d4cc99f58025c5f6652b8345243bb97b6d34325083</citedby><cites>FETCH-LOGICAL-c337t-b917bdc4029326359e0f4a0d4cc99f58025c5f6652b8345243bb97b6d34325083</cites><orcidid>0000-0001-7723-4647</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37255236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Qiang</creatorcontrib><creatorcontrib>Song, Yu-Fei</creatorcontrib><creatorcontrib>Wu, Wei-Na</creatorcontrib><creatorcontrib>Zhao, Xiao-Lei</creatorcontrib><creatorcontrib>Wang, Yuan</creatorcontrib><creatorcontrib>Fan, Yun-Chang</creatorcontrib><title>A coumarin-pyrazole-based probe for the fluorescence detection of phosgene with high selectivity and sensitivity</title><title>Analytical methods</title><addtitle>Anal Methods</addtitle><description>The high toxicity of phosgene poses potential threats to public health and safety. In this work, a novel fluorescent probe was designed to detect phosgene using hydroxyl and pyrazole moieties as the recognition sites. The response to phosgene with probe
1
was fast (less than 30 s), highly selective and sensitive with the limit of detection being 4.78 nM in solution. Furthermore, probe
1
was employed to conveniently fabricate paper test strips for efficiently detecting phosgene gas. The limit of detection was obtained as 0.014 ppm by using a smartphone RGB app, revealing that probe
1
has good prospects for sensitively detecting phosgene gas.
In this study, we reported a coumarin-pyrazole-based probe for the fluorescence detection of phosgene. Probe
1
responded rapidly to phosgene with good selectivity and high sensitivity, especially for phosgene gas-phase detection.</description><subject>Coumarin</subject><subject>Coumarins</subject><subject>Fluorescence</subject><subject>Fluorescent Dyes</subject><subject>Fluorescent indicators</subject><subject>Phosgene</subject><subject>Public health</subject><subject>Pyrazole</subject><subject>Pyrazoles</subject><subject>Spectrometry, Fluorescence</subject><subject>Toxicity</subject><issn>1759-9660</issn><issn>1759-9679</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkUFP3DAQhS1U1AXaC3cqS70gpFDbEzvxcUWBglbi0h56imJnsskqG6d2QrX8erzdZZF6mhm9T08z8wg55-yaM9DfKig3jEmuVkfkhGdSJ1pl-sOhV2xGTkNYMaY0KP6RzCATUgpQJ2SYU-umdenbPhk2vnxxHSamDFjRwTuDtHaejk2s3eQ8Bou9RVrhiHZsXU9dTYfGhSX2SP-2Y0ObdtnQgN1Wf27HDS37Ks59aHfzJ3Jcl13Az_t6Rn7d3f68-ZEsnu4fbuaLxAJkY2I0z0xlUyY0CAVSI6vTklWptVrXMmdCWlkrJYXJIZUiBWN0ZlQFKQjJcjgjlzvfeMafCcNYrNu4fdeVPbopFCIXHFIh-Rb9-h-6cpPv43ZbCqTSOWSRutpR1rsQPNbF4Nv4uE3BWbHNofgO89__cniM8Je95WTWWB3Qt8dH4GIH-GAP6nuQ8ArnyYz8</recordid><startdate>20230608</startdate><enddate>20230608</enddate><creator>Hu, Qiang</creator><creator>Song, Yu-Fei</creator><creator>Wu, Wei-Na</creator><creator>Zhao, Xiao-Lei</creator><creator>Wang, Yuan</creator><creator>Fan, Yun-Chang</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SE</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>H8G</scope><scope>JG9</scope><scope>L7M</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7723-4647</orcidid></search><sort><creationdate>20230608</creationdate><title>A coumarin-pyrazole-based probe for the fluorescence detection of phosgene with high selectivity and sensitivity</title><author>Hu, Qiang ; Song, Yu-Fei ; Wu, Wei-Na ; Zhao, Xiao-Lei ; Wang, Yuan ; Fan, Yun-Chang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-b917bdc4029326359e0f4a0d4cc99f58025c5f6652b8345243bb97b6d34325083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Coumarin</topic><topic>Coumarins</topic><topic>Fluorescence</topic><topic>Fluorescent Dyes</topic><topic>Fluorescent indicators</topic><topic>Phosgene</topic><topic>Public health</topic><topic>Pyrazole</topic><topic>Pyrazoles</topic><topic>Spectrometry, Fluorescence</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Qiang</creatorcontrib><creatorcontrib>Song, Yu-Fei</creatorcontrib><creatorcontrib>Wu, Wei-Na</creatorcontrib><creatorcontrib>Zhao, Xiao-Lei</creatorcontrib><creatorcontrib>Wang, Yuan</creatorcontrib><creatorcontrib>Fan, Yun-Chang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical methods</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Qiang</au><au>Song, Yu-Fei</au><au>Wu, Wei-Na</au><au>Zhao, Xiao-Lei</au><au>Wang, Yuan</au><au>Fan, Yun-Chang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A coumarin-pyrazole-based probe for the fluorescence detection of phosgene with high selectivity and sensitivity</atitle><jtitle>Analytical methods</jtitle><addtitle>Anal Methods</addtitle><date>2023-06-08</date><risdate>2023</risdate><volume>15</volume><issue>22</issue><spage>2761</spage><epage>2765</epage><pages>2761-2765</pages><issn>1759-9660</issn><eissn>1759-9679</eissn><abstract>The high toxicity of phosgene poses potential threats to public health and safety. In this work, a novel fluorescent probe was designed to detect phosgene using hydroxyl and pyrazole moieties as the recognition sites. The response to phosgene with probe
1
was fast (less than 30 s), highly selective and sensitive with the limit of detection being 4.78 nM in solution. Furthermore, probe
1
was employed to conveniently fabricate paper test strips for efficiently detecting phosgene gas. The limit of detection was obtained as 0.014 ppm by using a smartphone RGB app, revealing that probe
1
has good prospects for sensitively detecting phosgene gas.
In this study, we reported a coumarin-pyrazole-based probe for the fluorescence detection of phosgene. Probe
1
responded rapidly to phosgene with good selectivity and high sensitivity, especially for phosgene gas-phase detection.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>37255236</pmid><doi>10.1039/d3ay00516j</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-7723-4647</orcidid></addata></record> |
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| identifier | ISSN: 1759-9660 |
| ispartof | Analytical methods, 2023-06, Vol.15 (22), p.2761-2765 |
| issn | 1759-9660 1759-9679 |
| language | eng |
| recordid | cdi_proquest_journals_2823569837 |
| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Coumarin Coumarins Fluorescence Fluorescent Dyes Fluorescent indicators Phosgene Public health Pyrazole Pyrazoles Spectrometry, Fluorescence Toxicity |
| title | A coumarin-pyrazole-based probe for the fluorescence detection of phosgene with high selectivity and sensitivity |
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