Interaction between Iron Nitrosyl Complexes and Phosphatidylcholine Membranes: A Fluorescence Study
Fluorescent probes: 8-anilino-1-naphthalenesulfonate (ANS), eosin Y, and pyrene were used to study the interaction between liposomes and three nitrosyl iron complexes that are promising anti-inflammatory agents and cardioprotectors. It was shown that the studied complexes compete with ANS molecules...
Gespeichert in:
| Veröffentlicht in: | Russian Journal of Physical Chemistry A 2023-05, Vol.97 (5), p.822-827 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 827 |
|---|---|
| container_issue | 5 |
| container_start_page | 822 |
| container_title | Russian Journal of Physical Chemistry A |
| container_volume | 97 |
| creator | Poletaeva, D. A. Faingold, I. I. Soldatova, Yu. V. Smolina, A. V. Savushkin, M. A. Sanina, N. A. Aldoshin, S. M. |
| description | Fluorescent probes: 8-anilino-1-naphthalenesulfonate (ANS), eosin Y, and pyrene were used to study the interaction between liposomes and three nitrosyl iron complexes that are promising anti-inflammatory agents and cardioprotectors. It was shown that the studied complexes compete with ANS molecules for the bonding sites in a bilayer of liposomes. The incorporation of the complexes into the lipid bilayer was also studied according to the quenching of eosin Y and pyrene fluorescence. The data suggest that iron nitrosyl complexes interact with the phospholipids headgroups and can penetrate deeper into the hydrophobic center of a lipid bilayer, where they affect the packing of fatty acid chains. The pronounced membranotropic properties of the complexes correlated with their ability to inhibit lipid peroxidation. Complexes with high constants of pyrene bonding are the most effective antioxidants. |
| doi_str_mv | 10.1134/S0036024423050217 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2823082728</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2823082728</sourcerecordid><originalsourceid>FETCH-LOGICAL-c268t-5ff27af5281280b3b7b80900e382fd36bfd37e3028ce00bbda93fc0854bb7b523</originalsourceid><addsrcrecordid>eNp1kFtLw0AQhRdRsFZ_gG8LPkdnL2m2vpXipVAvUAXfwu5mYlPSTdxN0Px7t1TwQXyZYTjfmWEOIecMLhkT8moFICbApeQCUuAsOyAjlgqWqIl4OySjnZzs9GNyEsIGQErJ5IjYhevQa9tVjaMGu09ERxc-Do9V55sw1HTebNsavzBQ7Qr6vG5Cu9ZdVQy1XTd15ZA-4NZ47TBc0xm9rfvGY7DoLNJV1xfDKTkqdR3w7KePyevtzcv8Plk-3S3ms2Vi-UR1SVqWPNNlyhXjCowwmVEwBUCheFmIiYklQwFcWQQwptBTUVpQqTQRTbkYk4v93tY3Hz2GLt80vXfxZM5VzEXxjKtIsT1l43vBY5m3vtpqP-QM8l2W-Z8so4fvPSGy7h397-b_Td-FP3aW</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2823082728</pqid></control><display><type>article</type><title>Interaction between Iron Nitrosyl Complexes and Phosphatidylcholine Membranes: A Fluorescence Study</title><source>SpringerLink Journals - AutoHoldings</source><creator>Poletaeva, D. A. ; Faingold, I. I. ; Soldatova, Yu. V. ; Smolina, A. V. ; Savushkin, M. A. ; Sanina, N. A. ; Aldoshin, S. M.</creator><creatorcontrib>Poletaeva, D. A. ; Faingold, I. I. ; Soldatova, Yu. V. ; Smolina, A. V. ; Savushkin, M. A. ; Sanina, N. A. ; Aldoshin, S. M.</creatorcontrib><description>Fluorescent probes: 8-anilino-1-naphthalenesulfonate (ANS), eosin Y, and pyrene were used to study the interaction between liposomes and three nitrosyl iron complexes that are promising anti-inflammatory agents and cardioprotectors. It was shown that the studied complexes compete with ANS molecules for the bonding sites in a bilayer of liposomes. The incorporation of the complexes into the lipid bilayer was also studied according to the quenching of eosin Y and pyrene fluorescence. The data suggest that iron nitrosyl complexes interact with the phospholipids headgroups and can penetrate deeper into the hydrophobic center of a lipid bilayer, where they affect the packing of fatty acid chains. The pronounced membranotropic properties of the complexes correlated with their ability to inhibit lipid peroxidation. Complexes with high constants of pyrene bonding are the most effective antioxidants.</description><identifier>ISSN: 0036-0244</identifier><identifier>EISSN: 1531-863X</identifier><identifier>DOI: 10.1134/S0036024423050217</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Chemical bonds ; Chemistry ; Chemistry and Materials Science ; Fatty acids ; Fluorescent indicators ; Iron ; Lipids ; Liposomes ; Phosphatidylcholine ; Phospholipids ; Physical Chemistry ; Physics and Chemistry of Elementary Chemical Processes</subject><ispartof>Russian Journal of Physical Chemistry A, 2023-05, Vol.97 (5), p.822-827</ispartof><rights>Pleiades Publishing, Ltd. 2023. ISSN 0036-0244, Russian Journal of Physical Chemistry A, 2023, Vol. 97, No. 5, pp. 822–827. © Pleiades Publishing, Ltd., 2023. Russian Text © The Author(s), 2023, published in Zhurnal Fizicheskoi Khimii, 2023, Vol. 97, No. 5, pp. 617–623.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c268t-5ff27af5281280b3b7b80900e382fd36bfd37e3028ce00bbda93fc0854bb7b523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S0036024423050217$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S0036024423050217$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Poletaeva, D. A.</creatorcontrib><creatorcontrib>Faingold, I. I.</creatorcontrib><creatorcontrib>Soldatova, Yu. V.</creatorcontrib><creatorcontrib>Smolina, A. V.</creatorcontrib><creatorcontrib>Savushkin, M. A.</creatorcontrib><creatorcontrib>Sanina, N. A.</creatorcontrib><creatorcontrib>Aldoshin, S. M.</creatorcontrib><title>Interaction between Iron Nitrosyl Complexes and Phosphatidylcholine Membranes: A Fluorescence Study</title><title>Russian Journal of Physical Chemistry A</title><addtitle>Russ. J. Phys. Chem</addtitle><description>Fluorescent probes: 8-anilino-1-naphthalenesulfonate (ANS), eosin Y, and pyrene were used to study the interaction between liposomes and three nitrosyl iron complexes that are promising anti-inflammatory agents and cardioprotectors. It was shown that the studied complexes compete with ANS molecules for the bonding sites in a bilayer of liposomes. The incorporation of the complexes into the lipid bilayer was also studied according to the quenching of eosin Y and pyrene fluorescence. The data suggest that iron nitrosyl complexes interact with the phospholipids headgroups and can penetrate deeper into the hydrophobic center of a lipid bilayer, where they affect the packing of fatty acid chains. The pronounced membranotropic properties of the complexes correlated with their ability to inhibit lipid peroxidation. Complexes with high constants of pyrene bonding are the most effective antioxidants.</description><subject>Chemical bonds</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Fatty acids</subject><subject>Fluorescent indicators</subject><subject>Iron</subject><subject>Lipids</subject><subject>Liposomes</subject><subject>Phosphatidylcholine</subject><subject>Phospholipids</subject><subject>Physical Chemistry</subject><subject>Physics and Chemistry of Elementary Chemical Processes</subject><issn>0036-0244</issn><issn>1531-863X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kFtLw0AQhRdRsFZ_gG8LPkdnL2m2vpXipVAvUAXfwu5mYlPSTdxN0Px7t1TwQXyZYTjfmWEOIecMLhkT8moFICbApeQCUuAsOyAjlgqWqIl4OySjnZzs9GNyEsIGQErJ5IjYhevQa9tVjaMGu09ERxc-Do9V55sw1HTebNsavzBQ7Qr6vG5Cu9ZdVQy1XTd15ZA-4NZ47TBc0xm9rfvGY7DoLNJV1xfDKTkqdR3w7KePyevtzcv8Plk-3S3ms2Vi-UR1SVqWPNNlyhXjCowwmVEwBUCheFmIiYklQwFcWQQwptBTUVpQqTQRTbkYk4v93tY3Hz2GLt80vXfxZM5VzEXxjKtIsT1l43vBY5m3vtpqP-QM8l2W-Z8so4fvPSGy7h397-b_Td-FP3aW</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Poletaeva, D. A.</creator><creator>Faingold, I. I.</creator><creator>Soldatova, Yu. V.</creator><creator>Smolina, A. V.</creator><creator>Savushkin, M. A.</creator><creator>Sanina, N. A.</creator><creator>Aldoshin, S. M.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20230501</creationdate><title>Interaction between Iron Nitrosyl Complexes and Phosphatidylcholine Membranes: A Fluorescence Study</title><author>Poletaeva, D. A. ; Faingold, I. I. ; Soldatova, Yu. V. ; Smolina, A. V. ; Savushkin, M. A. ; Sanina, N. A. ; Aldoshin, S. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c268t-5ff27af5281280b3b7b80900e382fd36bfd37e3028ce00bbda93fc0854bb7b523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Chemical bonds</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Fatty acids</topic><topic>Fluorescent indicators</topic><topic>Iron</topic><topic>Lipids</topic><topic>Liposomes</topic><topic>Phosphatidylcholine</topic><topic>Phospholipids</topic><topic>Physical Chemistry</topic><topic>Physics and Chemistry of Elementary Chemical Processes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Poletaeva, D. A.</creatorcontrib><creatorcontrib>Faingold, I. I.</creatorcontrib><creatorcontrib>Soldatova, Yu. V.</creatorcontrib><creatorcontrib>Smolina, A. V.</creatorcontrib><creatorcontrib>Savushkin, M. A.</creatorcontrib><creatorcontrib>Sanina, N. A.</creatorcontrib><creatorcontrib>Aldoshin, S. M.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian Journal of Physical Chemistry A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Poletaeva, D. A.</au><au>Faingold, I. I.</au><au>Soldatova, Yu. V.</au><au>Smolina, A. V.</au><au>Savushkin, M. A.</au><au>Sanina, N. A.</au><au>Aldoshin, S. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction between Iron Nitrosyl Complexes and Phosphatidylcholine Membranes: A Fluorescence Study</atitle><jtitle>Russian Journal of Physical Chemistry A</jtitle><stitle>Russ. J. Phys. Chem</stitle><date>2023-05-01</date><risdate>2023</risdate><volume>97</volume><issue>5</issue><spage>822</spage><epage>827</epage><pages>822-827</pages><issn>0036-0244</issn><eissn>1531-863X</eissn><abstract>Fluorescent probes: 8-anilino-1-naphthalenesulfonate (ANS), eosin Y, and pyrene were used to study the interaction between liposomes and three nitrosyl iron complexes that are promising anti-inflammatory agents and cardioprotectors. It was shown that the studied complexes compete with ANS molecules for the bonding sites in a bilayer of liposomes. The incorporation of the complexes into the lipid bilayer was also studied according to the quenching of eosin Y and pyrene fluorescence. The data suggest that iron nitrosyl complexes interact with the phospholipids headgroups and can penetrate deeper into the hydrophobic center of a lipid bilayer, where they affect the packing of fatty acid chains. The pronounced membranotropic properties of the complexes correlated with their ability to inhibit lipid peroxidation. Complexes with high constants of pyrene bonding are the most effective antioxidants.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S0036024423050217</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-0244 |
| ispartof | Russian Journal of Physical Chemistry A, 2023-05, Vol.97 (5), p.822-827 |
| issn | 0036-0244 1531-863X |
| language | eng |
| recordid | cdi_proquest_journals_2823082728 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Chemical bonds Chemistry Chemistry and Materials Science Fatty acids Fluorescent indicators Iron Lipids Liposomes Phosphatidylcholine Phospholipids Physical Chemistry Physics and Chemistry of Elementary Chemical Processes |
| title | Interaction between Iron Nitrosyl Complexes and Phosphatidylcholine Membranes: A Fluorescence Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T17%3A49%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Interaction%20between%20Iron%20Nitrosyl%20Complexes%20and%20Phosphatidylcholine%20Membranes:%20A%20Fluorescence%20Study&rft.jtitle=Russian%20Journal%20of%20Physical%20Chemistry%20A&rft.au=Poletaeva,%20D.%20A.&rft.date=2023-05-01&rft.volume=97&rft.issue=5&rft.spage=822&rft.epage=827&rft.pages=822-827&rft.issn=0036-0244&rft.eissn=1531-863X&rft_id=info:doi/10.1134/S0036024423050217&rft_dat=%3Cproquest_cross%3E2823082728%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2823082728&rft_id=info:pmid/&rfr_iscdi=true |