THE THERAPEUTIC EFFECT OF A Lactobacillus Rhamnosus PROBIOTIC AGAINST CHRONIC LEAD-INDUCED NEUROTOXICITY IN DEVELOPING WISTAR RATS (GESTATION AND LACTATION)
This study aims to examine the effects induced by lead acetate (Pb) using different experimental approaches, such as neurobehavioral, biochemical, and histological in young Wistar rats during gestation and lactation, and to test the probiotic effect of Lactobacillus rhamnosus (Prob) throughout corre...
Gespeichert in:
| Veröffentlicht in: | Fresenius environmental bulletin 2023-05, Vol.32 (5), p.2350 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 5 |
| container_start_page | 2350 |
| container_title | Fresenius environmental bulletin |
| container_volume | 32 |
| creator | Adli, Djallel Eddine Houari Benreguieg, Mokhtar Brahmi, Mostapha Ziani, Kaddour Arabi, Wafaa Hachem, Kadda Kahloula, Khaled Slimani, Miloud |
| description | This study aims to examine the effects induced by lead acetate (Pb) using different experimental approaches, such as neurobehavioral, biochemical, and histological in young Wistar rats during gestation and lactation, and to test the probiotic effect of Lactobacillus rhamnosus (Prob) throughout correcting or not the harmful effects of the studied metal. Chronic exposure to 0.2% lead acetate in rats during the development period resulted in a decrease in body and brain weights compared to controls. Test results for depression (forced swimming test), anxiety (Elevated plus ma2e), and locomotor and exploratory activity (Open field) all show that Pb intoxication causes neurobehavioraldisorders, leading to decreased locomotor activity and a reduction of the exploration behavior of the environment which reflects the establishment of a state of stress, anxiety, and depression. In fact, the histopathological analysis revealed significant lesions in the brain tissue. Furthermore, the administration of probiotics (Prob) allowed the rats to regain body and brain weight when compared to the intoxicated rats. In addition, the use of various behavioral test techniques reveals that the administration of Lactobacillus rhamnosus corrects the depressive state, locomotor hypoactivity, and anxiety observed in rats exposed to Pb. Blood antioxidant status analysis revealed that Prob restored the activity of different antioxidant enzymes (SOD, CAT, GPx, and GSH) and non-enzymatic enzymes (glutathione) in rats intoxicated and treated with Prob. In effect, the histological study showed a significant improvement in the brain histology in rats intoxicated and treated with Prob. This illustrates the important implications of probiotic lactobacilli and their therapeutic properties. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_2822800227</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2822800227</sourcerecordid><originalsourceid>FETCH-proquest_journals_28228002273</originalsourceid><addsrcrecordid>eNqNit1Kw0AUhBexYLF9hwPe6EVgsylpvFw3J8mBsBs2G3-uSiwVLbHRbvM2Pqwr-gAODDMfM2dsHqcxj0TCV-eh8ziLVml8e8GW3u95UCrWIk3m7MtVCMFWNtg5UoBFgcqBKUBC3W9P43O_fRuGyYN97d8Pow-tseaOzM9blpJ060BV1ujANco8Ip13CnPQ2FnjzCMpck9AGnK8x9o0pEt4oNZJC1a6Fq5LDODIaJA6h1qqX7pZsNlLP_jd8i8v2VWBTlXRx3H8nHb-tNmP0_EQpo3IhMg4F2Kd_O_1DSuDUBk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2822800227</pqid></control><display><type>article</type><title>THE THERAPEUTIC EFFECT OF A Lactobacillus Rhamnosus PROBIOTIC AGAINST CHRONIC LEAD-INDUCED NEUROTOXICITY IN DEVELOPING WISTAR RATS (GESTATION AND LACTATION)</title><source>EZB-FREE-00999 freely available EZB journals</source><creator>Adli, Djallel Eddine Houari ; Benreguieg, Mokhtar ; Brahmi, Mostapha ; Ziani, Kaddour ; Arabi, Wafaa ; Hachem, Kadda ; Kahloula, Khaled ; Slimani, Miloud</creator><creatorcontrib>Adli, Djallel Eddine Houari ; Benreguieg, Mokhtar ; Brahmi, Mostapha ; Ziani, Kaddour ; Arabi, Wafaa ; Hachem, Kadda ; Kahloula, Khaled ; Slimani, Miloud</creatorcontrib><description>This study aims to examine the effects induced by lead acetate (Pb) using different experimental approaches, such as neurobehavioral, biochemical, and histological in young Wistar rats during gestation and lactation, and to test the probiotic effect of Lactobacillus rhamnosus (Prob) throughout correcting or not the harmful effects of the studied metal. Chronic exposure to 0.2% lead acetate in rats during the development period resulted in a decrease in body and brain weights compared to controls. Test results for depression (forced swimming test), anxiety (Elevated plus ma2e), and locomotor and exploratory activity (Open field) all show that Pb intoxication causes neurobehavioraldisorders, leading to decreased locomotor activity and a reduction of the exploration behavior of the environment which reflects the establishment of a state of stress, anxiety, and depression. In fact, the histopathological analysis revealed significant lesions in the brain tissue. Furthermore, the administration of probiotics (Prob) allowed the rats to regain body and brain weight when compared to the intoxicated rats. In addition, the use of various behavioral test techniques reveals that the administration of Lactobacillus rhamnosus corrects the depressive state, locomotor hypoactivity, and anxiety observed in rats exposed to Pb. Blood antioxidant status analysis revealed that Prob restored the activity of different antioxidant enzymes (SOD, CAT, GPx, and GSH) and non-enzymatic enzymes (glutathione) in rats intoxicated and treated with Prob. In effect, the histological study showed a significant improvement in the brain histology in rats intoxicated and treated with Prob. This illustrates the important implications of probiotic lactobacilli and their therapeutic properties.</description><identifier>ISSN: 1018-4619</identifier><identifier>EISSN: 1610-2304</identifier><language>eng</language><publisher>Freising: Parlar Scientific Publications</publisher><subject>Antioxidants ; Anxiety ; Brain ; Breastfeeding & lactation ; Chronic exposure ; Enzymes ; Exploratory behavior ; Gestation ; Glutathione ; Histology ; Intoxication ; Lactation ; Lactobacilli ; Lactobacillus rhamnosus ; Lead ; Lead acetates ; Locomotor activity ; Mental depression ; Neurotoxicity ; Probiotics</subject><ispartof>Fresenius environmental bulletin, 2023-05, Vol.32 (5), p.2350</ispartof><rights>Copyright Parlar Scientific Publications May 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids></links><search><creatorcontrib>Adli, Djallel Eddine Houari</creatorcontrib><creatorcontrib>Benreguieg, Mokhtar</creatorcontrib><creatorcontrib>Brahmi, Mostapha</creatorcontrib><creatorcontrib>Ziani, Kaddour</creatorcontrib><creatorcontrib>Arabi, Wafaa</creatorcontrib><creatorcontrib>Hachem, Kadda</creatorcontrib><creatorcontrib>Kahloula, Khaled</creatorcontrib><creatorcontrib>Slimani, Miloud</creatorcontrib><title>THE THERAPEUTIC EFFECT OF A Lactobacillus Rhamnosus PROBIOTIC AGAINST CHRONIC LEAD-INDUCED NEUROTOXICITY IN DEVELOPING WISTAR RATS (GESTATION AND LACTATION)</title><title>Fresenius environmental bulletin</title><description>This study aims to examine the effects induced by lead acetate (Pb) using different experimental approaches, such as neurobehavioral, biochemical, and histological in young Wistar rats during gestation and lactation, and to test the probiotic effect of Lactobacillus rhamnosus (Prob) throughout correcting or not the harmful effects of the studied metal. Chronic exposure to 0.2% lead acetate in rats during the development period resulted in a decrease in body and brain weights compared to controls. Test results for depression (forced swimming test), anxiety (Elevated plus ma2e), and locomotor and exploratory activity (Open field) all show that Pb intoxication causes neurobehavioraldisorders, leading to decreased locomotor activity and a reduction of the exploration behavior of the environment which reflects the establishment of a state of stress, anxiety, and depression. In fact, the histopathological analysis revealed significant lesions in the brain tissue. Furthermore, the administration of probiotics (Prob) allowed the rats to regain body and brain weight when compared to the intoxicated rats. In addition, the use of various behavioral test techniques reveals that the administration of Lactobacillus rhamnosus corrects the depressive state, locomotor hypoactivity, and anxiety observed in rats exposed to Pb. Blood antioxidant status analysis revealed that Prob restored the activity of different antioxidant enzymes (SOD, CAT, GPx, and GSH) and non-enzymatic enzymes (glutathione) in rats intoxicated and treated with Prob. In effect, the histological study showed a significant improvement in the brain histology in rats intoxicated and treated with Prob. This illustrates the important implications of probiotic lactobacilli and their therapeutic properties.</description><subject>Antioxidants</subject><subject>Anxiety</subject><subject>Brain</subject><subject>Breastfeeding & lactation</subject><subject>Chronic exposure</subject><subject>Enzymes</subject><subject>Exploratory behavior</subject><subject>Gestation</subject><subject>Glutathione</subject><subject>Histology</subject><subject>Intoxication</subject><subject>Lactation</subject><subject>Lactobacilli</subject><subject>Lactobacillus rhamnosus</subject><subject>Lead</subject><subject>Lead acetates</subject><subject>Locomotor activity</subject><subject>Mental depression</subject><subject>Neurotoxicity</subject><subject>Probiotics</subject><issn>1018-4619</issn><issn>1610-2304</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqNit1Kw0AUhBexYLF9hwPe6EVgsylpvFw3J8mBsBs2G3-uSiwVLbHRbvM2Pqwr-gAODDMfM2dsHqcxj0TCV-eh8ziLVml8e8GW3u95UCrWIk3m7MtVCMFWNtg5UoBFgcqBKUBC3W9P43O_fRuGyYN97d8Pow-tseaOzM9blpJ060BV1ujANco8Ip13CnPQ2FnjzCMpck9AGnK8x9o0pEt4oNZJC1a6Fq5LDODIaJA6h1qqX7pZsNlLP_jd8i8v2VWBTlXRx3H8nHb-tNmP0_EQpo3IhMg4F2Kd_O_1DSuDUBk</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Adli, Djallel Eddine Houari</creator><creator>Benreguieg, Mokhtar</creator><creator>Brahmi, Mostapha</creator><creator>Ziani, Kaddour</creator><creator>Arabi, Wafaa</creator><creator>Hachem, Kadda</creator><creator>Kahloula, Khaled</creator><creator>Slimani, Miloud</creator><general>Parlar Scientific Publications</general><scope>7ST</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>SOI</scope></search><sort><creationdate>20230501</creationdate><title>THE THERAPEUTIC EFFECT OF A Lactobacillus Rhamnosus PROBIOTIC AGAINST CHRONIC LEAD-INDUCED NEUROTOXICITY IN DEVELOPING WISTAR RATS (GESTATION AND LACTATION)</title><author>Adli, Djallel Eddine Houari ; Benreguieg, Mokhtar ; Brahmi, Mostapha ; Ziani, Kaddour ; Arabi, Wafaa ; Hachem, Kadda ; Kahloula, Khaled ; Slimani, Miloud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_28228002273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antioxidants</topic><topic>Anxiety</topic><topic>Brain</topic><topic>Breastfeeding & lactation</topic><topic>Chronic exposure</topic><topic>Enzymes</topic><topic>Exploratory behavior</topic><topic>Gestation</topic><topic>Glutathione</topic><topic>Histology</topic><topic>Intoxication</topic><topic>Lactation</topic><topic>Lactobacilli</topic><topic>Lactobacillus rhamnosus</topic><topic>Lead</topic><topic>Lead acetates</topic><topic>Locomotor activity</topic><topic>Mental depression</topic><topic>Neurotoxicity</topic><topic>Probiotics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adli, Djallel Eddine Houari</creatorcontrib><creatorcontrib>Benreguieg, Mokhtar</creatorcontrib><creatorcontrib>Brahmi, Mostapha</creatorcontrib><creatorcontrib>Ziani, Kaddour</creatorcontrib><creatorcontrib>Arabi, Wafaa</creatorcontrib><creatorcontrib>Hachem, Kadda</creatorcontrib><creatorcontrib>Kahloula, Khaled</creatorcontrib><creatorcontrib>Slimani, Miloud</creatorcontrib><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Fresenius environmental bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adli, Djallel Eddine Houari</au><au>Benreguieg, Mokhtar</au><au>Brahmi, Mostapha</au><au>Ziani, Kaddour</au><au>Arabi, Wafaa</au><au>Hachem, Kadda</au><au>Kahloula, Khaled</au><au>Slimani, Miloud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>THE THERAPEUTIC EFFECT OF A Lactobacillus Rhamnosus PROBIOTIC AGAINST CHRONIC LEAD-INDUCED NEUROTOXICITY IN DEVELOPING WISTAR RATS (GESTATION AND LACTATION)</atitle><jtitle>Fresenius environmental bulletin</jtitle><date>2023-05-01</date><risdate>2023</risdate><volume>32</volume><issue>5</issue><spage>2350</spage><pages>2350-</pages><issn>1018-4619</issn><eissn>1610-2304</eissn><abstract>This study aims to examine the effects induced by lead acetate (Pb) using different experimental approaches, such as neurobehavioral, biochemical, and histological in young Wistar rats during gestation and lactation, and to test the probiotic effect of Lactobacillus rhamnosus (Prob) throughout correcting or not the harmful effects of the studied metal. Chronic exposure to 0.2% lead acetate in rats during the development period resulted in a decrease in body and brain weights compared to controls. Test results for depression (forced swimming test), anxiety (Elevated plus ma2e), and locomotor and exploratory activity (Open field) all show that Pb intoxication causes neurobehavioraldisorders, leading to decreased locomotor activity and a reduction of the exploration behavior of the environment which reflects the establishment of a state of stress, anxiety, and depression. In fact, the histopathological analysis revealed significant lesions in the brain tissue. Furthermore, the administration of probiotics (Prob) allowed the rats to regain body and brain weight when compared to the intoxicated rats. In addition, the use of various behavioral test techniques reveals that the administration of Lactobacillus rhamnosus corrects the depressive state, locomotor hypoactivity, and anxiety observed in rats exposed to Pb. Blood antioxidant status analysis revealed that Prob restored the activity of different antioxidant enzymes (SOD, CAT, GPx, and GSH) and non-enzymatic enzymes (glutathione) in rats intoxicated and treated with Prob. In effect, the histological study showed a significant improvement in the brain histology in rats intoxicated and treated with Prob. This illustrates the important implications of probiotic lactobacilli and their therapeutic properties.</abstract><cop>Freising</cop><pub>Parlar Scientific Publications</pub></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1018-4619 |
| ispartof | Fresenius environmental bulletin, 2023-05, Vol.32 (5), p.2350 |
| issn | 1018-4619 1610-2304 |
| language | eng |
| recordid | cdi_proquest_journals_2822800227 |
| source | EZB-FREE-00999 freely available EZB journals |
| subjects | Antioxidants Anxiety Brain Breastfeeding & lactation Chronic exposure Enzymes Exploratory behavior Gestation Glutathione Histology Intoxication Lactation Lactobacilli Lactobacillus rhamnosus Lead Lead acetates Locomotor activity Mental depression Neurotoxicity Probiotics |
| title | THE THERAPEUTIC EFFECT OF A Lactobacillus Rhamnosus PROBIOTIC AGAINST CHRONIC LEAD-INDUCED NEUROTOXICITY IN DEVELOPING WISTAR RATS (GESTATION AND LACTATION) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T03%3A05%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=THE%20THERAPEUTIC%20EFFECT%20OF%20A%20Lactobacillus%20Rhamnosus%20PROBIOTIC%20AGAINST%20CHRONIC%20LEAD-INDUCED%20NEUROTOXICITY%20IN%20DEVELOPING%20WISTAR%20RATS%20(GESTATION%20AND%20LACTATION)&rft.jtitle=Fresenius%20environmental%20bulletin&rft.au=Adli,%20Djallel%20Eddine%20Houari&rft.date=2023-05-01&rft.volume=32&rft.issue=5&rft.spage=2350&rft.pages=2350-&rft.issn=1018-4619&rft.eissn=1610-2304&rft_id=info:doi/&rft_dat=%3Cproquest%3E2822800227%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2822800227&rft_id=info:pmid/&rfr_iscdi=true |