Consideration of C1q and FcRn binding to allotypically disparate IgG3 could aid in engineering more efficacious anti-SARS-CoV-2 mAbs/Reply to Pandey: IgG3 allotypes, modulation of antigen binding by constant domain changes, and therapeutic applications of Fc engineering

Consideration of C1q and FcRn binding to allotypically disparate IgG3 could aid in engineering more efficacious anti-SARS-CoV-2 mAbs/Reply to Pandey: IgG3 allotypes, modulation of antigen binding by constant domain changes, and therapeutic applications of Fc engineering

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2023-05, Vol.120 (22), p.1
Hauptverfasser: Pandey, Janardan P, Izadi, Arman, Bahnan, Wael, Ohlin, Mats, Nordenfelt, Pontus
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Allotypes
Antigens
Binding
Immunoglobulin G
Severe acute respiratory syndrome coronavirus 2
Therapeutic applications
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container_title Proceedings of the National Academy of Sciences - PNAS
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creator Pandey, Janardan P
Izadi, Arman
Bahnan, Wael
Ohlin, Mats
Nordenfelt, Pontus
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source PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry
subjects Allotypes
Antigens
Binding
Immunoglobulin G
Severe acute respiratory syndrome coronavirus 2
Therapeutic applications
title Consideration of C1q and FcRn binding to allotypically disparate IgG3 could aid in engineering more efficacious anti-SARS-CoV-2 mAbs/Reply to Pandey: IgG3 allotypes, modulation of antigen binding by constant domain changes, and therapeutic applications of Fc engineering
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