Evaluation of efficacy of new chalcone-based endodontic irrigant against dual biofilm Enterococcus faecalis and Candida albicans : a study in vitro
[Abstract] The aim of this research was to develop a chalcone-based endodontic irrigant for cleaning and disinfecting the root canal. Minimal inhibitory concentration (MIC) experiments in C. albicans and E. faecalis strains with different aminochalcones (AM) were carried out, and the compound that p...
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| Veröffentlicht in: | Odontology 2023-07, Vol.111 (3), p.573-579 |
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| creator | Graciani, Joice Rosalen, Pedro Luiz de Oliveira Chaves dos Santos, Emmanuely Rocha, Kellyth Andrade Pereira Balen, Bruno Rafael Teixeira Garcia, Mayara Aparecida Rocha Lazarini, Josy Goldoni da Silva, Diego Romario Carvalho, Suzana Gonçalves Regasini, Luís Octávio Chorilli, Marlus Orlandi Sardi, Janaina de Cássia |
| description | [Abstract] The aim of this research was to develop a chalcone-based endodontic irrigant for cleaning and disinfecting the root canal. Minimal inhibitory concentration (MIC) experiments in C. albicans and E. faecalis strains with different aminochalcones (AM) were carried out, and the compound that presented the best activity against both pathogens was chosen. The formulation of an endodontic irrigant was elaborated, tested in mono and dual specie biofilms. Disks were sterilized and then incubated with E. faecalis, C. albicans and E. faecalis and C. albicans mixed for 72 h for biofilm maturation. After contamination, samples were divided in 4 experimental groups and 2 positive control group as follows: Group1: Irrigant; Group2: Irrigant + AM-38; Group3: Chlorhexidine 2% (positive control) and, Group4: 1.0% sodium hypochlorite (positive control). The samples were analyzed by CFU/ml count. The sample was taken to sonicador to remove the cells and then plated. The toxicity was determined in vitro with human gingival fibroblast cells (HGF) and in vivo using the Galleria mellonella model. Formulation showed antimicrobial activity, with MIC on C. albicans 15.6 and E. faecalis 7.8 μg/ml. Treatment with formulation in concentration 156 μg/ml significantly reduced mono or dual species biofilm formation and viability (p < 0.05). The results were significant against C. albicans and E. faecalis and did not show toxicity in cells and G. mellonella. In general, the formulation showed effective antibiofilm activity, significantly reducing microorganisms, opening paths in search of new endodontic irrigants. |
| doi_str_mv | 10.1007/s10266-022-00764-y |
| format | Article |
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Minimal inhibitory concentration (MIC) experiments in C. albicans and E. faecalis strains with different aminochalcones (AM) were carried out, and the compound that presented the best activity against both pathogens was chosen. The formulation of an endodontic irrigant was elaborated, tested in mono and dual specie biofilms. Disks were sterilized and then incubated with E. faecalis, C. albicans and E. faecalis and C. albicans mixed for 72 h for biofilm maturation. After contamination, samples were divided in 4 experimental groups and 2 positive control group as follows: Group1: Irrigant; Group2: Irrigant + AM-38; Group3: Chlorhexidine 2% (positive control) and, Group4: 1.0% sodium hypochlorite (positive control). The samples were analyzed by CFU/ml count. The sample was taken to sonicador to remove the cells and then plated. The toxicity was determined in vitro with human gingival fibroblast cells (HGF) and in vivo using the Galleria mellonella model. Formulation showed antimicrobial activity, with MIC on C. albicans 15.6 and E. faecalis 7.8 μg/ml. Treatment with formulation in concentration 156 μg/ml significantly reduced mono or dual species biofilm formation and viability (p < 0.05). The results were significant against C. albicans and E. faecalis and did not show toxicity in cells and G. mellonella. In general, the formulation showed effective antibiofilm activity, significantly reducing microorganisms, opening paths in search of new endodontic irrigants.</description><identifier>ISSN: 1618-1247</identifier><identifier>EISSN: 1618-1255</identifier><identifier>DOI: 10.1007/s10266-022-00764-y</identifier><identifier>PMID: 36414881</identifier><language>eng</language><publisher>Singapore: The Society of the Nippon Dental University</publisher><subject>Antimicrobial activity ; Biofilms ; Candida albicans ; Chalcones - pharmacology ; Chlorhexidine ; Contamination ; Dental Pulp Cavity ; Dentistry ; Enterococcus faecalis ; Humans ; Medicine ; Minimum inhibitory concentration ; Oral and Maxillofacial Surgery ; Original Article ; Root Canal Irrigants - pharmacology ; Root canals ; Sodium hypochlorite ; Sodium Hypochlorite - pharmacology ; Toxicity</subject><ispartof>Odontology, 2023-07, Vol.111 (3), p.573-579</ispartof><rights>The Author(s), under exclusive licence to The Society of The Nippon Dental University 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to The Society of The Nippon Dental University.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c414t-31d1293bf11976857f20e672b2fd53b4fc8c5bbf1a8afad8124c6329bac687373</cites><orcidid>0000-0002-8500-2691</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10266-022-00764-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10266-022-00764-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36414881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Graciani, Joice</creatorcontrib><creatorcontrib>Rosalen, Pedro Luiz</creatorcontrib><creatorcontrib>de Oliveira Chaves dos Santos, Emmanuely</creatorcontrib><creatorcontrib>Rocha, Kellyth Andrade Pereira</creatorcontrib><creatorcontrib>Balen, Bruno Rafael Teixeira</creatorcontrib><creatorcontrib>Garcia, Mayara Aparecida Rocha</creatorcontrib><creatorcontrib>Lazarini, Josy Goldoni</creatorcontrib><creatorcontrib>da Silva, Diego Romario</creatorcontrib><creatorcontrib>Carvalho, Suzana Gonçalves</creatorcontrib><creatorcontrib>Regasini, Luís Octávio</creatorcontrib><creatorcontrib>Chorilli, Marlus</creatorcontrib><creatorcontrib>Orlandi Sardi, Janaina de Cássia</creatorcontrib><creatorcontrib>Department of Chemistry and Environmental Sciences</creatorcontrib><creatorcontrib>PostGraduate Program On Integrated Dental Sciences</creatorcontrib><creatorcontrib>Department of Physiological Sciences</creatorcontrib><creatorcontrib>Program on Integrated Dental Sciences</creatorcontrib><creatorcontrib>School of Dentistry of the University of Cuiaba</creatorcontrib><creatorcontrib>University of Campinas</creatorcontrib><creatorcontrib>School of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>Dental Research Division</creatorcontrib><creatorcontrib>Faculty of Dentistry</creatorcontrib><creatorcontrib>Sao Paulo State University (UNESP</creatorcontrib><creatorcontrib>Department of Periodontology</creatorcontrib><creatorcontrib>Julio de Mesquita Filho University</creatorcontrib><creatorcontrib>Piracicaba Dental School</creatorcontrib><creatorcontrib>Guarulhos University</creatorcontrib><title>Evaluation of efficacy of new chalcone-based endodontic irrigant against dual biofilm Enterococcus faecalis and Candida albicans : a study in vitro</title><title>Odontology</title><addtitle>Odontology</addtitle><addtitle>Odontology</addtitle><description>[Abstract] The aim of this research was to develop a chalcone-based endodontic irrigant for cleaning and disinfecting the root canal. Minimal inhibitory concentration (MIC) experiments in C. albicans and E. faecalis strains with different aminochalcones (AM) were carried out, and the compound that presented the best activity against both pathogens was chosen. The formulation of an endodontic irrigant was elaborated, tested in mono and dual specie biofilms. Disks were sterilized and then incubated with E. faecalis, C. albicans and E. faecalis and C. albicans mixed for 72 h for biofilm maturation. After contamination, samples were divided in 4 experimental groups and 2 positive control group as follows: Group1: Irrigant; Group2: Irrigant + AM-38; Group3: Chlorhexidine 2% (positive control) and, Group4: 1.0% sodium hypochlorite (positive control). The samples were analyzed by CFU/ml count. The sample was taken to sonicador to remove the cells and then plated. The toxicity was determined in vitro with human gingival fibroblast cells (HGF) and in vivo using the Galleria mellonella model. 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In general, the formulation showed effective antibiofilm activity, significantly reducing microorganisms, opening paths in search of new endodontic irrigants.</description><subject>Antimicrobial activity</subject><subject>Biofilms</subject><subject>Candida albicans</subject><subject>Chalcones - pharmacology</subject><subject>Chlorhexidine</subject><subject>Contamination</subject><subject>Dental Pulp Cavity</subject><subject>Dentistry</subject><subject>Enterococcus faecalis</subject><subject>Humans</subject><subject>Medicine</subject><subject>Minimum inhibitory concentration</subject><subject>Oral and Maxillofacial Surgery</subject><subject>Original Article</subject><subject>Root Canal Irrigants - pharmacology</subject><subject>Root canals</subject><subject>Sodium hypochlorite</subject><subject>Sodium Hypochlorite - pharmacology</subject><subject>Toxicity</subject><issn>1618-1247</issn><issn>1618-1255</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uc1u1DAQjhCIVqUvwAFZ4hzqsZ044YZWS0GqxAXO1vhvMcraxU6K8hy8cL1NaW9cZsaa78ear2neAv0AlMqrApT1fUsZa-uzF-36ojmHHoYWWNe9fJqFPGsuSwmaCgZAJXSvmzPeCxDDAOfN3_0dTgvOIUWSPHHeB4NmPc3R_SHmJ04mRddqLM4SF22yKc7BkJBzOGCcCR4wxDITu-BEdEg-TEeyj7PLySRjlkI8OoNTKASjJbtagkWCk65OsZCPBEmZF7uSEMldmHN607zyOBV3-dgvmh-f9993X9qbb9dfd59uWlN_P7ccLLCRaw8wyn7opGfU9ZJp5m3HtfBmMJ2uaxzQox3qLUzP2ajR9IPkkl807zfd25x-L67M6ldacqyWig0Mxm6U4oRiG8rkVEp2Xt3mcMS8KqDqFIXaolA1CvUQhVor6d2j9KKPzj5R_h2-AvgGKHUVDy4_e_9X9npjVc16vSnFKUT3TDUHeMhHMcq4olADr412inaSn8ooGBeCAr8HJZSsoA</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Graciani, Joice</creator><creator>Rosalen, Pedro Luiz</creator><creator>de Oliveira Chaves dos Santos, Emmanuely</creator><creator>Rocha, Kellyth Andrade Pereira</creator><creator>Balen, Bruno Rafael Teixeira</creator><creator>Garcia, Mayara Aparecida Rocha</creator><creator>Lazarini, Josy Goldoni</creator><creator>da Silva, Diego Romario</creator><creator>Carvalho, Suzana Gonçalves</creator><creator>Regasini, Luís Octávio</creator><creator>Chorilli, Marlus</creator><creator>Orlandi Sardi, Janaina de Cássia</creator><general>The Society of the Nippon Dental University</general><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0002-8500-2691</orcidid></search><sort><creationdate>20230701</creationdate><title>Evaluation of efficacy of new chalcone-based endodontic irrigant against dual biofilm Enterococcus faecalis and Candida albicans : a study in vitro</title><author>Graciani, Joice ; Rosalen, Pedro Luiz ; de Oliveira Chaves dos Santos, Emmanuely ; Rocha, Kellyth Andrade Pereira ; Balen, Bruno Rafael Teixeira ; Garcia, Mayara Aparecida Rocha ; Lazarini, Josy Goldoni ; da Silva, Diego Romario ; Carvalho, Suzana Gonçalves ; Regasini, Luís Octávio ; Chorilli, Marlus ; Orlandi Sardi, Janaina de Cássia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-31d1293bf11976857f20e672b2fd53b4fc8c5bbf1a8afad8124c6329bac687373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antimicrobial activity</topic><topic>Biofilms</topic><topic>Candida albicans</topic><topic>Chalcones - pharmacology</topic><topic>Chlorhexidine</topic><topic>Contamination</topic><topic>Dental Pulp Cavity</topic><topic>Dentistry</topic><topic>Enterococcus faecalis</topic><topic>Humans</topic><topic>Medicine</topic><topic>Minimum inhibitory concentration</topic><topic>Oral and Maxillofacial Surgery</topic><topic>Original Article</topic><topic>Root Canal Irrigants - pharmacology</topic><topic>Root canals</topic><topic>Sodium hypochlorite</topic><topic>Sodium Hypochlorite - pharmacology</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Graciani, Joice</creatorcontrib><creatorcontrib>Rosalen, Pedro Luiz</creatorcontrib><creatorcontrib>de Oliveira Chaves dos Santos, Emmanuely</creatorcontrib><creatorcontrib>Rocha, Kellyth Andrade Pereira</creatorcontrib><creatorcontrib>Balen, Bruno Rafael Teixeira</creatorcontrib><creatorcontrib>Garcia, Mayara Aparecida Rocha</creatorcontrib><creatorcontrib>Lazarini, Josy Goldoni</creatorcontrib><creatorcontrib>da Silva, Diego Romario</creatorcontrib><creatorcontrib>Carvalho, Suzana Gonçalves</creatorcontrib><creatorcontrib>Regasini, Luís Octávio</creatorcontrib><creatorcontrib>Chorilli, Marlus</creatorcontrib><creatorcontrib>Orlandi Sardi, Janaina de Cássia</creatorcontrib><creatorcontrib>Department of Chemistry and Environmental Sciences</creatorcontrib><creatorcontrib>PostGraduate Program On Integrated Dental Sciences</creatorcontrib><creatorcontrib>Department of Physiological Sciences</creatorcontrib><creatorcontrib>Program on Integrated Dental Sciences</creatorcontrib><creatorcontrib>School of Dentistry of the University of Cuiaba</creatorcontrib><creatorcontrib>University of Campinas</creatorcontrib><creatorcontrib>School of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>Dental Research Division</creatorcontrib><creatorcontrib>Faculty of Dentistry</creatorcontrib><creatorcontrib>Sao Paulo State University (UNESP</creatorcontrib><creatorcontrib>Department of Periodontology</creatorcontrib><creatorcontrib>Julio de Mesquita Filho University</creatorcontrib><creatorcontrib>Piracicaba Dental School</creatorcontrib><creatorcontrib>Guarulhos University</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Odontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Graciani, Joice</au><au>Rosalen, Pedro Luiz</au><au>de Oliveira Chaves dos Santos, Emmanuely</au><au>Rocha, Kellyth Andrade Pereira</au><au>Balen, Bruno Rafael Teixeira</au><au>Garcia, Mayara Aparecida Rocha</au><au>Lazarini, Josy Goldoni</au><au>da Silva, Diego Romario</au><au>Carvalho, Suzana Gonçalves</au><au>Regasini, Luís Octávio</au><au>Chorilli, Marlus</au><au>Orlandi Sardi, Janaina de Cássia</au><aucorp>Department of Chemistry and Environmental Sciences</aucorp><aucorp>PostGraduate Program On Integrated Dental Sciences</aucorp><aucorp>Department of Physiological Sciences</aucorp><aucorp>Program on Integrated Dental Sciences</aucorp><aucorp>School of Dentistry of the University of Cuiaba</aucorp><aucorp>University of Campinas</aucorp><aucorp>School of Pharmaceutical Sciences</aucorp><aucorp>Dental Research Division</aucorp><aucorp>Faculty of Dentistry</aucorp><aucorp>Sao Paulo State University (UNESP</aucorp><aucorp>Department of Periodontology</aucorp><aucorp>Julio de Mesquita Filho University</aucorp><aucorp>Piracicaba Dental School</aucorp><aucorp>Guarulhos University</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of efficacy of new chalcone-based endodontic irrigant against dual biofilm Enterococcus faecalis and Candida albicans : a study in vitro</atitle><jtitle>Odontology</jtitle><stitle>Odontology</stitle><addtitle>Odontology</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>111</volume><issue>3</issue><spage>573</spage><epage>579</epage><pages>573-579</pages><issn>1618-1247</issn><eissn>1618-1255</eissn><abstract>[Abstract] The aim of this research was to develop a chalcone-based endodontic irrigant for cleaning and disinfecting the root canal. Minimal inhibitory concentration (MIC) experiments in C. albicans and E. faecalis strains with different aminochalcones (AM) were carried out, and the compound that presented the best activity against both pathogens was chosen. The formulation of an endodontic irrigant was elaborated, tested in mono and dual specie biofilms. Disks were sterilized and then incubated with E. faecalis, C. albicans and E. faecalis and C. albicans mixed for 72 h for biofilm maturation. After contamination, samples were divided in 4 experimental groups and 2 positive control group as follows: Group1: Irrigant; Group2: Irrigant + AM-38; Group3: Chlorhexidine 2% (positive control) and, Group4: 1.0% sodium hypochlorite (positive control). The samples were analyzed by CFU/ml count. The sample was taken to sonicador to remove the cells and then plated. The toxicity was determined in vitro with human gingival fibroblast cells (HGF) and in vivo using the Galleria mellonella model. Formulation showed antimicrobial activity, with MIC on C. albicans 15.6 and E. faecalis 7.8 μg/ml. Treatment with formulation in concentration 156 μg/ml significantly reduced mono or dual species biofilm formation and viability (p < 0.05). The results were significant against C. albicans and E. faecalis and did not show toxicity in cells and G. mellonella. In general, the formulation showed effective antibiofilm activity, significantly reducing microorganisms, opening paths in search of new endodontic irrigants.</abstract><cop>Singapore</cop><pub>The Society of the Nippon Dental University</pub><pmid>36414881</pmid><doi>10.1007/s10266-022-00764-y</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8500-2691</orcidid></addata></record> |
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| ispartof | Odontology, 2023-07, Vol.111 (3), p.573-579 |
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| subjects | Antimicrobial activity Biofilms Candida albicans Chalcones - pharmacology Chlorhexidine Contamination Dental Pulp Cavity Dentistry Enterococcus faecalis Humans Medicine Minimum inhibitory concentration Oral and Maxillofacial Surgery Original Article Root Canal Irrigants - pharmacology Root canals Sodium hypochlorite Sodium Hypochlorite - pharmacology Toxicity |
| title | Evaluation of efficacy of new chalcone-based endodontic irrigant against dual biofilm Enterococcus faecalis and Candida albicans : a study in vitro |
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