Chemical Composition, Antimicrobial, Antiparasitic, and Cytotoxic Activities of Rhanterium intermedium Pomel Leaves Essential Oil
This study evaluates the chemical composition, antimicrobial, antiparasitic, and cytotoxic activities of essential oil extracted from Rhanterium intermedium Pomel (EORI) leaves. The chemical composition of the essential oil was analyzed by GC/MS analysis. In addition, the antimicrobial capacity of E...
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| Veröffentlicht in: | Arabian journal for science and engineering (2011) 2023-06, Vol.48 (6), p.7337-7347 |
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| creator | Mahcene, Salem Elhouiti, Fatiha Mennai, Imad Pinto, Diana C. G. A. Tahri, Djilali Ouinten, Mohamed Yousfi, Mohamed |
| description | This study evaluates the chemical composition, antimicrobial, antiparasitic, and cytotoxic activities of essential oil extracted from
Rhanterium intermedium
Pomel (EORI) leaves. The chemical composition of the essential oil was analyzed by GC/MS analysis. In addition, the antimicrobial capacity of EORI against five pathogenic bacteria and two yeast strains was determined by disk diffusion and broth microdilution methods. Alamar Blue® assay was used to evaluate the antiparasitic potential of EORI against epimastigotes forms of
Trypanosoma cruzi
, trophozoïtes forms of
Acanthamoeba castellanii
Neff., and promastigotes forms of
Leishmania amazonensis
and
Leishmania donovani
. The same assay was used to assess the cytotoxicity effect of oil against murine macrophage J774. A1 cell line. GC/MS results showed that the EORI comprised 22 compounds, representing 97.99% of the total composition. The main constituents of EORI were camphene (32.08%), myrcene (13.86%),
α
-pinene (11.29%), sabinene (5.85%), and
β
-pinene (5.73%). Additionally, a significant antibacterial effect was recorded against
Escherichia coli
with MIC inferior to 14.78 mg/mL. Concerning the antifungal activity, EORI showed a remarkable efficiency against the two tested
Candida albicans
strains (MIC = 14.78 mg/mL). The EORI showed promising antiparasitic activity against epimastigotes forms of
Trypanosoma cruzi
(IC
50
= 07.21 ± 0.09 μg/mL) and low cytotoxicity levels on murine macrophages (LD
50
= 47.91 ± 3.61 μg/mL). Overall, it was shown that our tested essential oil possesses potential antimicrobial and antiparasitic capacities; also, it is considered safe to use. Further detailed investigations are needed to ensure EORI as a novel source of alternative drugs for microbial and parasitic diseases. |
| doi_str_mv | 10.1007/s13369-023-07913-7 |
| format | Article |
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Rhanterium intermedium
Pomel (EORI) leaves. The chemical composition of the essential oil was analyzed by GC/MS analysis. In addition, the antimicrobial capacity of EORI against five pathogenic bacteria and two yeast strains was determined by disk diffusion and broth microdilution methods. Alamar Blue® assay was used to evaluate the antiparasitic potential of EORI against epimastigotes forms of
Trypanosoma cruzi
, trophozoïtes forms of
Acanthamoeba castellanii
Neff., and promastigotes forms of
Leishmania amazonensis
and
Leishmania donovani
. The same assay was used to assess the cytotoxicity effect of oil against murine macrophage J774. A1 cell line. GC/MS results showed that the EORI comprised 22 compounds, representing 97.99% of the total composition. The main constituents of EORI were camphene (32.08%), myrcene (13.86%),
α
-pinene (11.29%), sabinene (5.85%), and
β
-pinene (5.73%). Additionally, a significant antibacterial effect was recorded against
Escherichia coli
with MIC inferior to 14.78 mg/mL. Concerning the antifungal activity, EORI showed a remarkable efficiency against the two tested
Candida albicans
strains (MIC = 14.78 mg/mL). The EORI showed promising antiparasitic activity against epimastigotes forms of
Trypanosoma cruzi
(IC
50
= 07.21 ± 0.09 μg/mL) and low cytotoxicity levels on murine macrophages (LD
50
= 47.91 ± 3.61 μg/mL). Overall, it was shown that our tested essential oil possesses potential antimicrobial and antiparasitic capacities; also, it is considered safe to use. Further detailed investigations are needed to ensure EORI as a novel source of alternative drugs for microbial and parasitic diseases.</description><identifier>ISSN: 2193-567X</identifier><identifier>ISSN: 1319-8025</identifier><identifier>EISSN: 2191-4281</identifier><identifier>DOI: 10.1007/s13369-023-07913-7</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Antiinfectives and antibacterials ; Chemical composition ; Cytotoxicity ; E coli ; Engineering ; Essential oils ; Fungicides ; Humanities and Social Sciences ; Macrophages ; Microorganisms ; multidisciplinary ; Oils & fats ; Parasitic diseases ; Protozoa ; Research Article-Biological Sciences ; Science ; Toxicity</subject><ispartof>Arabian journal for science and engineering (2011), 2023-06, Vol.48 (6), p.7337-7347</ispartof><rights>King Fahd University of Petroleum & Minerals 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-6eb1fcf746a814d38f3eebcb45295a75153255e21b9329559c1ee5d253d0588d3</citedby><cites>FETCH-LOGICAL-c319t-6eb1fcf746a814d38f3eebcb45295a75153255e21b9329559c1ee5d253d0588d3</cites><orcidid>0000-0002-8482-3164</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13369-023-07913-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13369-023-07913-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27925,27926,41489,42558,51320</link.rule.ids></links><search><creatorcontrib>Mahcene, Salem</creatorcontrib><creatorcontrib>Elhouiti, Fatiha</creatorcontrib><creatorcontrib>Mennai, Imad</creatorcontrib><creatorcontrib>Pinto, Diana C. G. A.</creatorcontrib><creatorcontrib>Tahri, Djilali</creatorcontrib><creatorcontrib>Ouinten, Mohamed</creatorcontrib><creatorcontrib>Yousfi, Mohamed</creatorcontrib><title>Chemical Composition, Antimicrobial, Antiparasitic, and Cytotoxic Activities of Rhanterium intermedium Pomel Leaves Essential Oil</title><title>Arabian journal for science and engineering (2011)</title><addtitle>Arab J Sci Eng</addtitle><description>This study evaluates the chemical composition, antimicrobial, antiparasitic, and cytotoxic activities of essential oil extracted from
Rhanterium intermedium
Pomel (EORI) leaves. The chemical composition of the essential oil was analyzed by GC/MS analysis. In addition, the antimicrobial capacity of EORI against five pathogenic bacteria and two yeast strains was determined by disk diffusion and broth microdilution methods. Alamar Blue® assay was used to evaluate the antiparasitic potential of EORI against epimastigotes forms of
Trypanosoma cruzi
, trophozoïtes forms of
Acanthamoeba castellanii
Neff., and promastigotes forms of
Leishmania amazonensis
and
Leishmania donovani
. The same assay was used to assess the cytotoxicity effect of oil against murine macrophage J774. A1 cell line. GC/MS results showed that the EORI comprised 22 compounds, representing 97.99% of the total composition. The main constituents of EORI were camphene (32.08%), myrcene (13.86%),
α
-pinene (11.29%), sabinene (5.85%), and
β
-pinene (5.73%). Additionally, a significant antibacterial effect was recorded against
Escherichia coli
with MIC inferior to 14.78 mg/mL. Concerning the antifungal activity, EORI showed a remarkable efficiency against the two tested
Candida albicans
strains (MIC = 14.78 mg/mL). The EORI showed promising antiparasitic activity against epimastigotes forms of
Trypanosoma cruzi
(IC
50
= 07.21 ± 0.09 μg/mL) and low cytotoxicity levels on murine macrophages (LD
50
= 47.91 ± 3.61 μg/mL). Overall, it was shown that our tested essential oil possesses potential antimicrobial and antiparasitic capacities; also, it is considered safe to use. Further detailed investigations are needed to ensure EORI as a novel source of alternative drugs for microbial and parasitic diseases.</description><subject>Antiinfectives and antibacterials</subject><subject>Chemical composition</subject><subject>Cytotoxicity</subject><subject>E coli</subject><subject>Engineering</subject><subject>Essential oils</subject><subject>Fungicides</subject><subject>Humanities and Social Sciences</subject><subject>Macrophages</subject><subject>Microorganisms</subject><subject>multidisciplinary</subject><subject>Oils & fats</subject><subject>Parasitic diseases</subject><subject>Protozoa</subject><subject>Research Article-Biological Sciences</subject><subject>Science</subject><subject>Toxicity</subject><issn>2193-567X</issn><issn>1319-8025</issn><issn>2191-4281</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9UE1LxDAQDaLgovsHPAW8brWTNP04LmX9gIUVUfAW0nbqRtqmJt3FPfrPTbeCN0_zZua9N8wj5ArCGwjD5NYB53EWhIwHYZIBD5ITMmOQQRCxFE6PmAciTt7Oydw5XYRRyjMBwGfkO99iq0vV0Ny0vXF60KZb0GU3aD-2ptCqmdpeWTWuywVVXUXzw2AG86VLuiwHvfcLdNTU9HmrugGt3rVUj6DFasRPpsWGrlHtPW3lHHpHf3Sjm0tyVqvG4fy3XpDXu9VL_hCsN_eP-XIdlByyIYixgLqskyhWKUQVT2uOWJRFJFgmVCJAcCYEMigy7iciKwFRVEzwKhRpWvELcj359tZ87tAN8sPsbOdPSpYy4Enk9Z7FJpb_3TmLteytbpU9SAjlmLac0pY-bXlMWyZexCeR8-TuHe2f9T-qH1rdhAQ</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Mahcene, Salem</creator><creator>Elhouiti, Fatiha</creator><creator>Mennai, Imad</creator><creator>Pinto, Diana C. G. A.</creator><creator>Tahri, Djilali</creator><creator>Ouinten, Mohamed</creator><creator>Yousfi, Mohamed</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-8482-3164</orcidid></search><sort><creationdate>20230601</creationdate><title>Chemical Composition, Antimicrobial, Antiparasitic, and Cytotoxic Activities of Rhanterium intermedium Pomel Leaves Essential Oil</title><author>Mahcene, Salem ; Elhouiti, Fatiha ; Mennai, Imad ; Pinto, Diana C. G. A. ; Tahri, Djilali ; Ouinten, Mohamed ; Yousfi, Mohamed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-6eb1fcf746a814d38f3eebcb45295a75153255e21b9329559c1ee5d253d0588d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antiinfectives and antibacterials</topic><topic>Chemical composition</topic><topic>Cytotoxicity</topic><topic>E coli</topic><topic>Engineering</topic><topic>Essential oils</topic><topic>Fungicides</topic><topic>Humanities and Social Sciences</topic><topic>Macrophages</topic><topic>Microorganisms</topic><topic>multidisciplinary</topic><topic>Oils & fats</topic><topic>Parasitic diseases</topic><topic>Protozoa</topic><topic>Research Article-Biological Sciences</topic><topic>Science</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mahcene, Salem</creatorcontrib><creatorcontrib>Elhouiti, Fatiha</creatorcontrib><creatorcontrib>Mennai, Imad</creatorcontrib><creatorcontrib>Pinto, Diana C. G. A.</creatorcontrib><creatorcontrib>Tahri, Djilali</creatorcontrib><creatorcontrib>Ouinten, Mohamed</creatorcontrib><creatorcontrib>Yousfi, Mohamed</creatorcontrib><collection>CrossRef</collection><jtitle>Arabian journal for science and engineering (2011)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mahcene, Salem</au><au>Elhouiti, Fatiha</au><au>Mennai, Imad</au><au>Pinto, Diana C. G. A.</au><au>Tahri, Djilali</au><au>Ouinten, Mohamed</au><au>Yousfi, Mohamed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemical Composition, Antimicrobial, Antiparasitic, and Cytotoxic Activities of Rhanterium intermedium Pomel Leaves Essential Oil</atitle><jtitle>Arabian journal for science and engineering (2011)</jtitle><stitle>Arab J Sci Eng</stitle><date>2023-06-01</date><risdate>2023</risdate><volume>48</volume><issue>6</issue><spage>7337</spage><epage>7347</epage><pages>7337-7347</pages><issn>2193-567X</issn><issn>1319-8025</issn><eissn>2191-4281</eissn><abstract>This study evaluates the chemical composition, antimicrobial, antiparasitic, and cytotoxic activities of essential oil extracted from
Rhanterium intermedium
Pomel (EORI) leaves. The chemical composition of the essential oil was analyzed by GC/MS analysis. In addition, the antimicrobial capacity of EORI against five pathogenic bacteria and two yeast strains was determined by disk diffusion and broth microdilution methods. Alamar Blue® assay was used to evaluate the antiparasitic potential of EORI against epimastigotes forms of
Trypanosoma cruzi
, trophozoïtes forms of
Acanthamoeba castellanii
Neff., and promastigotes forms of
Leishmania amazonensis
and
Leishmania donovani
. The same assay was used to assess the cytotoxicity effect of oil against murine macrophage J774. A1 cell line. GC/MS results showed that the EORI comprised 22 compounds, representing 97.99% of the total composition. The main constituents of EORI were camphene (32.08%), myrcene (13.86%),
α
-pinene (11.29%), sabinene (5.85%), and
β
-pinene (5.73%). Additionally, a significant antibacterial effect was recorded against
Escherichia coli
with MIC inferior to 14.78 mg/mL. Concerning the antifungal activity, EORI showed a remarkable efficiency against the two tested
Candida albicans
strains (MIC = 14.78 mg/mL). The EORI showed promising antiparasitic activity against epimastigotes forms of
Trypanosoma cruzi
(IC
50
= 07.21 ± 0.09 μg/mL) and low cytotoxicity levels on murine macrophages (LD
50
= 47.91 ± 3.61 μg/mL). Overall, it was shown that our tested essential oil possesses potential antimicrobial and antiparasitic capacities; also, it is considered safe to use. Further detailed investigations are needed to ensure EORI as a novel source of alternative drugs for microbial and parasitic diseases.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s13369-023-07913-7</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-8482-3164</orcidid></addata></record> |
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| ispartof | Arabian journal for science and engineering (2011), 2023-06, Vol.48 (6), p.7337-7347 |
| issn | 2193-567X 1319-8025 2191-4281 |
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| subjects | Antiinfectives and antibacterials Chemical composition Cytotoxicity E coli Engineering Essential oils Fungicides Humanities and Social Sciences Macrophages Microorganisms multidisciplinary Oils & fats Parasitic diseases Protozoa Research Article-Biological Sciences Science Toxicity |
| title | Chemical Composition, Antimicrobial, Antiparasitic, and Cytotoxic Activities of Rhanterium intermedium Pomel Leaves Essential Oil |
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