Total synthesis and biological evaluation of histone deacetylase inhibitor WF-3161

A novel synthesis of the naturally occurring HDAC inhibitor WF-3161 is described. Key steps include the Matteson homologation to generate the stereogenic centres in the side chain, and Pd-catalysed C-H functionalisation to connect the side chain to the peptide backbone. WF-3161 was found to be highl...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Organic & biomolecular chemistry 2023-05, Vol.21 (21), p.4382-4387
Hauptverfasser:	Kohr, Michael, Papenkordt, Niklas, Jung, Manfred, Kazmaier, Uli
Format:	Artikel
Sprache:	eng
Schlagworte:	Histone deacetylase Histone Deacetylase 6 Histone Deacetylase Inhibitors - chemistry Histone Deacetylases - metabolism Inhibitors Peptides Synthesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!