A manganese-phenolic network platform amplifying STING activation to potentiate MRI guided cancer chemo-/chemodynamic/immune therapy

Low immune infiltration severely hinders the efficacy of cancer immunotherapy. Here, we developed a manganese-phenolic network platform (TMPD) to boost antitumor immunity via a stimulator of interferon gene (STING)-amplified activation cascade. TMPD is based on doxorubicin (DOX)-loaded PEG-PLGA nano...

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Veröffentlicht in:	Biomaterials science 2023-05, Vol.11 (11), p.384-385
Hauptverfasser:	Pang, Xinrui, Fu, Chaoping, Chen, Junbin, Su, Miao, Wei, Ruili, Wang, Ye, Lin, Wanxian, Wei, Xinhua, Jiang, Xinqing, Yang, Xianzhu, Yang, Huikang, Wang, Junxia, Yang, Ruimeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Amplification Anticancer properties Antigens Cancer Cell death Contrast agents Damage patterns Deoxyribonucleic acid DNA Doxorubicin Immunotherapy Infiltration Lymphocytes Magnetic resonance imaging Manganese Nanoparticles Stimulators Tannic acid
Online-Zugang:	Volltext
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