Anticancerous and antioxidant properties of fabricated silver nanoparticles involving bio-organic framework using medicinal plant Blumea lacera
Cancer is the second foremost cause of death worldwide, and despite modern medicine development, it is needed to develop new plant-based drugs. The current study is mainly focused on the estimation of anticancerous activity of silver nanoparticles (AgNPs) fabricated by a simple and eco-friendly gree...
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| Veröffentlicht in: | Chemical papers 2023-07, Vol.77 (7), p.3603-3617 |
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| creator | Pandey, Pradeep Kumar Gangwar, Chinky Yaseen, Bushra Kumar, Indresh Nayak, Rashmi Kumar, Saurabh Naik, Radhey Mohan Banerjee, Monisha Sarkar, Joy |
| description | Cancer is the second foremost cause of death worldwide, and despite modern medicine development, it is needed to develop new plant-based drugs. The current study is mainly focused on the estimation of anticancerous activity of silver nanoparticles (AgNPs) fabricated by a simple and eco-friendly green approach by using leaf extract of the medicinal plant
Blumea lacera (B. lacera).
The prepared AgNPs were characterized by using different analytical tools. UV–visible spectra were recorded, which exhibited a sharp surface plasmonic resonance (SPR) band at 430 nm and confirmed the formation of AgNPs. The spherical morphology of synthesized AgNPs was determined with the help of field emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM), and the average particle size was calculated using TEM and found to be 12.52 nm. The Fourier transformed infrared (FT-IR) spectrum of AgNPs showed characteristic bands of functional groups present in the biomolecules adsorb onto AgNPs, acting as a stabilizing agent. The crystallite nature of AgNPs formed was confirmed by the powder X-ray diffraction (PXRD) technique. The anticancerous activity of synthesized AgNPs was investigated against adherent human lung carcinoma cell A549. The minimal inhibition concentration (IC
50
or MIC) value was found to be ~ 20 μg/mL for human lung carcinoma cell A549, and the result so obtained suggests that synthesized AgNPs via
B. lacera
possess a good ability to be used as an eco-friendly anticancerous agent. Moreover, the synthesized AgNPs possess good antioxidant activity compared to
B. lacera
plant leaves. The minimal inhibition concentration (IC
50
) of ~ 6 μg/mL for synthesized AgNPs was found.
Graphical abstract |
| doi_str_mv | 10.1007/s11696-023-02723-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2819851466</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2819851466</sourcerecordid><originalsourceid>FETCH-LOGICAL-c319t-9dd6e02450a57fdb5a1535a2dc01e1b195fec8678c28c8e56591d3a67ffe72b3</originalsourceid><addsrcrecordid>eNp9kL9u2zAQxokiAeokfYFOBDorIUWTkkbHaJICAbJ4J07k0aArkyopOe1T5JVLVwG6Zbi74X7f_fkI-crZLWesucucq05VrBYlmpLlJ7LiQqiqY428ICsmlKqUkPVncpXzgbH1mkm2Im-bMHkDwWCKc6YQbInJx9_elkrHFEdMk8dMo6MO-lTgCS3NfjhhogFCHKEAZiiID6c4nHzY097HKqY9BG-oS3DE15h-0jmfe0e03vgAAx2H8477YT4i0AHKDXBDLh0MGb-812uye_i-2z5Vzy-PP7ab58oI3k1VZ61CVq8lA9k420vgUkiorWEcec876dC0qmlN3ZoWpZIdtwJU4xw2dS-uybdlbHnw14x50oc4p3JT1nXLu1bytVKFqhfKpJhzQqfH5I-Q_mjO9Nl3vfiui-_6n-9aFpFYRLnAYY_p_-gPVH8BESWKDA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2819851466</pqid></control><display><type>article</type><title>Anticancerous and antioxidant properties of fabricated silver nanoparticles involving bio-organic framework using medicinal plant Blumea lacera</title><source>SpringerLink Journals - AutoHoldings</source><creator>Pandey, Pradeep Kumar ; Gangwar, Chinky ; Yaseen, Bushra ; Kumar, Indresh ; Nayak, Rashmi ; Kumar, Saurabh ; Naik, Radhey Mohan ; Banerjee, Monisha ; Sarkar, Joy</creator><creatorcontrib>Pandey, Pradeep Kumar ; Gangwar, Chinky ; Yaseen, Bushra ; Kumar, Indresh ; Nayak, Rashmi ; Kumar, Saurabh ; Naik, Radhey Mohan ; Banerjee, Monisha ; Sarkar, Joy</creatorcontrib><description>Cancer is the second foremost cause of death worldwide, and despite modern medicine development, it is needed to develop new plant-based drugs. The current study is mainly focused on the estimation of anticancerous activity of silver nanoparticles (AgNPs) fabricated by a simple and eco-friendly green approach by using leaf extract of the medicinal plant
Blumea lacera (B. lacera).
The prepared AgNPs were characterized by using different analytical tools. UV–visible spectra were recorded, which exhibited a sharp surface plasmonic resonance (SPR) band at 430 nm and confirmed the formation of AgNPs. The spherical morphology of synthesized AgNPs was determined with the help of field emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM), and the average particle size was calculated using TEM and found to be 12.52 nm. The Fourier transformed infrared (FT-IR) spectrum of AgNPs showed characteristic bands of functional groups present in the biomolecules adsorb onto AgNPs, acting as a stabilizing agent. The crystallite nature of AgNPs formed was confirmed by the powder X-ray diffraction (PXRD) technique. The anticancerous activity of synthesized AgNPs was investigated against adherent human lung carcinoma cell A549. The minimal inhibition concentration (IC
50
or MIC) value was found to be ~ 20 μg/mL for human lung carcinoma cell A549, and the result so obtained suggests that synthesized AgNPs via
B. lacera
possess a good ability to be used as an eco-friendly anticancerous agent. Moreover, the synthesized AgNPs possess good antioxidant activity compared to
B. lacera
plant leaves. The minimal inhibition concentration (IC
50
) of ~ 6 μg/mL for synthesized AgNPs was found.
Graphical abstract</description><identifier>ISSN: 0366-6352</identifier><identifier>EISSN: 1336-9075</identifier><identifier>EISSN: 2585-7290</identifier><identifier>DOI: 10.1007/s11696-023-02723-5</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Antioxidants ; Biochemistry ; Biomolecules ; Biotechnology ; Cancer ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Crystallites ; Field emission microscopy ; Functional groups ; Herbal medicine ; Industrial Chemistry/Chemical Engineering ; Infrared radiation ; Lungs ; Materials Science ; Medicinal Chemistry ; Microscopy ; Nanoparticles ; Original Paper ; Silver ; Stabilizers (agents) ; Synthesis ; Transmission electron microscopy ; X ray powder diffraction</subject><ispartof>Chemical papers, 2023-07, Vol.77 (7), p.3603-3617</ispartof><rights>Institute of Chemistry, Slovak Academy of Sciences 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-9dd6e02450a57fdb5a1535a2dc01e1b195fec8678c28c8e56591d3a67ffe72b3</citedby><cites>FETCH-LOGICAL-c319t-9dd6e02450a57fdb5a1535a2dc01e1b195fec8678c28c8e56591d3a67ffe72b3</cites><orcidid>0000-0001-7451-4926</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11696-023-02723-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11696-023-02723-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids></links><search><creatorcontrib>Pandey, Pradeep Kumar</creatorcontrib><creatorcontrib>Gangwar, Chinky</creatorcontrib><creatorcontrib>Yaseen, Bushra</creatorcontrib><creatorcontrib>Kumar, Indresh</creatorcontrib><creatorcontrib>Nayak, Rashmi</creatorcontrib><creatorcontrib>Kumar, Saurabh</creatorcontrib><creatorcontrib>Naik, Radhey Mohan</creatorcontrib><creatorcontrib>Banerjee, Monisha</creatorcontrib><creatorcontrib>Sarkar, Joy</creatorcontrib><title>Anticancerous and antioxidant properties of fabricated silver nanoparticles involving bio-organic framework using medicinal plant Blumea lacera</title><title>Chemical papers</title><addtitle>Chem. Pap</addtitle><description>Cancer is the second foremost cause of death worldwide, and despite modern medicine development, it is needed to develop new plant-based drugs. The current study is mainly focused on the estimation of anticancerous activity of silver nanoparticles (AgNPs) fabricated by a simple and eco-friendly green approach by using leaf extract of the medicinal plant
Blumea lacera (B. lacera).
The prepared AgNPs were characterized by using different analytical tools. UV–visible spectra were recorded, which exhibited a sharp surface plasmonic resonance (SPR) band at 430 nm and confirmed the formation of AgNPs. The spherical morphology of synthesized AgNPs was determined with the help of field emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM), and the average particle size was calculated using TEM and found to be 12.52 nm. The Fourier transformed infrared (FT-IR) spectrum of AgNPs showed characteristic bands of functional groups present in the biomolecules adsorb onto AgNPs, acting as a stabilizing agent. The crystallite nature of AgNPs formed was confirmed by the powder X-ray diffraction (PXRD) technique. The anticancerous activity of synthesized AgNPs was investigated against adherent human lung carcinoma cell A549. The minimal inhibition concentration (IC
50
or MIC) value was found to be ~ 20 μg/mL for human lung carcinoma cell A549, and the result so obtained suggests that synthesized AgNPs via
B. lacera
possess a good ability to be used as an eco-friendly anticancerous agent. Moreover, the synthesized AgNPs possess good antioxidant activity compared to
B. lacera
plant leaves. The minimal inhibition concentration (IC
50
) of ~ 6 μg/mL for synthesized AgNPs was found.
Graphical abstract</description><subject>Antioxidants</subject><subject>Biochemistry</subject><subject>Biomolecules</subject><subject>Biotechnology</subject><subject>Cancer</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Crystallites</subject><subject>Field emission microscopy</subject><subject>Functional groups</subject><subject>Herbal medicine</subject><subject>Industrial Chemistry/Chemical Engineering</subject><subject>Infrared radiation</subject><subject>Lungs</subject><subject>Materials Science</subject><subject>Medicinal Chemistry</subject><subject>Microscopy</subject><subject>Nanoparticles</subject><subject>Original Paper</subject><subject>Silver</subject><subject>Stabilizers (agents)</subject><subject>Synthesis</subject><subject>Transmission electron microscopy</subject><subject>X ray powder diffraction</subject><issn>0366-6352</issn><issn>1336-9075</issn><issn>2585-7290</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kL9u2zAQxokiAeokfYFOBDorIUWTkkbHaJICAbJ4J07k0aArkyopOe1T5JVLVwG6Zbi74X7f_fkI-crZLWesucucq05VrBYlmpLlJ7LiQqiqY428ICsmlKqUkPVncpXzgbH1mkm2Im-bMHkDwWCKc6YQbInJx9_elkrHFEdMk8dMo6MO-lTgCS3NfjhhogFCHKEAZiiID6c4nHzY097HKqY9BG-oS3DE15h-0jmfe0e03vgAAx2H8477YT4i0AHKDXBDLh0MGb-812uye_i-2z5Vzy-PP7ab58oI3k1VZ61CVq8lA9k420vgUkiorWEcec876dC0qmlN3ZoWpZIdtwJU4xw2dS-uybdlbHnw14x50oc4p3JT1nXLu1bytVKFqhfKpJhzQqfH5I-Q_mjO9Nl3vfiui-_6n-9aFpFYRLnAYY_p_-gPVH8BESWKDA</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Pandey, Pradeep Kumar</creator><creator>Gangwar, Chinky</creator><creator>Yaseen, Bushra</creator><creator>Kumar, Indresh</creator><creator>Nayak, Rashmi</creator><creator>Kumar, Saurabh</creator><creator>Naik, Radhey Mohan</creator><creator>Banerjee, Monisha</creator><creator>Sarkar, Joy</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0001-7451-4926</orcidid></search><sort><creationdate>20230701</creationdate><title>Anticancerous and antioxidant properties of fabricated silver nanoparticles involving bio-organic framework using medicinal plant Blumea lacera</title><author>Pandey, Pradeep Kumar ; Gangwar, Chinky ; Yaseen, Bushra ; Kumar, Indresh ; Nayak, Rashmi ; Kumar, Saurabh ; Naik, Radhey Mohan ; Banerjee, Monisha ; Sarkar, Joy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-9dd6e02450a57fdb5a1535a2dc01e1b195fec8678c28c8e56591d3a67ffe72b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antioxidants</topic><topic>Biochemistry</topic><topic>Biomolecules</topic><topic>Biotechnology</topic><topic>Cancer</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Crystallites</topic><topic>Field emission microscopy</topic><topic>Functional groups</topic><topic>Herbal medicine</topic><topic>Industrial Chemistry/Chemical Engineering</topic><topic>Infrared radiation</topic><topic>Lungs</topic><topic>Materials Science</topic><topic>Medicinal Chemistry</topic><topic>Microscopy</topic><topic>Nanoparticles</topic><topic>Original Paper</topic><topic>Silver</topic><topic>Stabilizers (agents)</topic><topic>Synthesis</topic><topic>Transmission electron microscopy</topic><topic>X ray powder diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pandey, Pradeep Kumar</creatorcontrib><creatorcontrib>Gangwar, Chinky</creatorcontrib><creatorcontrib>Yaseen, Bushra</creatorcontrib><creatorcontrib>Kumar, Indresh</creatorcontrib><creatorcontrib>Nayak, Rashmi</creatorcontrib><creatorcontrib>Kumar, Saurabh</creatorcontrib><creatorcontrib>Naik, Radhey Mohan</creatorcontrib><creatorcontrib>Banerjee, Monisha</creatorcontrib><creatorcontrib>Sarkar, Joy</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Chemical papers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pandey, Pradeep Kumar</au><au>Gangwar, Chinky</au><au>Yaseen, Bushra</au><au>Kumar, Indresh</au><au>Nayak, Rashmi</au><au>Kumar, Saurabh</au><au>Naik, Radhey Mohan</au><au>Banerjee, Monisha</au><au>Sarkar, Joy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anticancerous and antioxidant properties of fabricated silver nanoparticles involving bio-organic framework using medicinal plant Blumea lacera</atitle><jtitle>Chemical papers</jtitle><stitle>Chem. Pap</stitle><date>2023-07-01</date><risdate>2023</risdate><volume>77</volume><issue>7</issue><spage>3603</spage><epage>3617</epage><pages>3603-3617</pages><issn>0366-6352</issn><eissn>1336-9075</eissn><eissn>2585-7290</eissn><abstract>Cancer is the second foremost cause of death worldwide, and despite modern medicine development, it is needed to develop new plant-based drugs. The current study is mainly focused on the estimation of anticancerous activity of silver nanoparticles (AgNPs) fabricated by a simple and eco-friendly green approach by using leaf extract of the medicinal plant
Blumea lacera (B. lacera).
The prepared AgNPs were characterized by using different analytical tools. UV–visible spectra were recorded, which exhibited a sharp surface plasmonic resonance (SPR) band at 430 nm and confirmed the formation of AgNPs. The spherical morphology of synthesized AgNPs was determined with the help of field emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM), and the average particle size was calculated using TEM and found to be 12.52 nm. The Fourier transformed infrared (FT-IR) spectrum of AgNPs showed characteristic bands of functional groups present in the biomolecules adsorb onto AgNPs, acting as a stabilizing agent. The crystallite nature of AgNPs formed was confirmed by the powder X-ray diffraction (PXRD) technique. The anticancerous activity of synthesized AgNPs was investigated against adherent human lung carcinoma cell A549. The minimal inhibition concentration (IC
50
or MIC) value was found to be ~ 20 μg/mL for human lung carcinoma cell A549, and the result so obtained suggests that synthesized AgNPs via
B. lacera
possess a good ability to be used as an eco-friendly anticancerous agent. Moreover, the synthesized AgNPs possess good antioxidant activity compared to
B. lacera
plant leaves. The minimal inhibition concentration (IC
50
) of ~ 6 μg/mL for synthesized AgNPs was found.
Graphical abstract</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s11696-023-02723-5</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0001-7451-4926</orcidid></addata></record> |
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| subjects | Antioxidants Biochemistry Biomolecules Biotechnology Cancer Chemistry Chemistry and Materials Science Chemistry/Food Science Crystallites Field emission microscopy Functional groups Herbal medicine Industrial Chemistry/Chemical Engineering Infrared radiation Lungs Materials Science Medicinal Chemistry Microscopy Nanoparticles Original Paper Silver Stabilizers (agents) Synthesis Transmission electron microscopy X ray powder diffraction |
| title | Anticancerous and antioxidant properties of fabricated silver nanoparticles involving bio-organic framework using medicinal plant Blumea lacera |
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