Genetic Polymorphism of Mismatch Repair Genes and Susceptibility to Prostate Cancer
Mismatch repair (MMR) is one of the DNA repair systems that correct mispaired bases during DNA replication errors. Polymorphisms in genes can increase susceptibility to the development of prostate cancer (PCa). In this study, we investigated mutL homolog 1 (MLH1) -93G>A (rs1800734) and mutS homol...
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| Veröffentlicht in: | Urology journal 2020-05, Vol.17 (3), p.271 |
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| creator | Khooshemehri, Paniz Jamaldini, Seyed Hamid Ziaee, Seyed Amir Mohsen Afshari, Mahdi Sattari, Mahshid Narouie, Behzad Sotoudeh, Mehdi Montazeri, Vahideh Sarhangi, Negar Hasanzad, Mandana |
| description | Mismatch repair (MMR) is one of the DNA repair systems that correct mispaired bases during DNA replication errors. Polymorphisms in genes can increase susceptibility to the development of prostate cancer (PCa). In this study, we investigated mutL homolog 1 (MLH1) -93G>A (rs1800734) and mutS homolog 3 (MSH3) (rs26279) polymorphisms with the risk of PCa.
In this study of Iranian population, 175 histopathologically confirmed (PCa) patients and 230 benign prostate hyperplasia (BPH) as the controls were recruited. The genotypes of MLH1 and MSH3 were determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method.
There was no significant difference of MLH1 (P = 0.4) and MSH3 (P?=?0.5) genotype distributions among PCa cases and controls. And also patients with PCa were not significant differences compared to those without in stage of cancer, grade of tumor, perineural invasion, and vascular invasion.
Our results did not show adequate evidence for any significant association of MLH1 and MSH3 polymorphisms and PCa . |
| doi_str_mv | 10.22037/uj.v0i0.5051 |
| format | Article |
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In this study of Iranian population, 175 histopathologically confirmed (PCa) patients and 230 benign prostate hyperplasia (BPH) as the controls were recruited. The genotypes of MLH1 and MSH3 were determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method.
There was no significant difference of MLH1 (P = 0.4) and MSH3 (P?=?0.5) genotype distributions among PCa cases and controls. And also patients with PCa were not significant differences compared to those without in stage of cancer, grade of tumor, perineural invasion, and vascular invasion.
Our results did not show adequate evidence for any significant association of MLH1 and MSH3 polymorphisms and PCa .</description><identifier>ISSN: 1735-1308</identifier><identifier>EISSN: 1735-546X</identifier><identifier>DOI: 10.22037/uj.v0i0.5051</identifier><identifier>PMID: 31953835</identifier><language>eng</language><publisher>Iran: Urology and Nephrology Research Center</publisher><subject>Aged ; Case-Control Studies ; DNA Mismatch Repair ; Genetic Predisposition to Disease ; Humans ; Iran ; Male ; Middle Aged ; MutL Protein Homolog 1 - genetics ; MutS Homolog 3 Protein - genetics ; Polymorphism ; Polymorphism, Restriction Fragment Length ; Prostate cancer ; Prostatic Neoplasms - genetics ; Yeast</subject><ispartof>Urology journal, 2020-05, Vol.17 (3), p.271</ispartof><rights>Copyright Urology and Nephrology Research Center May-Jun 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31953835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khooshemehri, Paniz</creatorcontrib><creatorcontrib>Jamaldini, Seyed Hamid</creatorcontrib><creatorcontrib>Ziaee, Seyed Amir Mohsen</creatorcontrib><creatorcontrib>Afshari, Mahdi</creatorcontrib><creatorcontrib>Sattari, Mahshid</creatorcontrib><creatorcontrib>Narouie, Behzad</creatorcontrib><creatorcontrib>Sotoudeh, Mehdi</creatorcontrib><creatorcontrib>Montazeri, Vahideh</creatorcontrib><creatorcontrib>Sarhangi, Negar</creatorcontrib><creatorcontrib>Hasanzad, Mandana</creatorcontrib><title>Genetic Polymorphism of Mismatch Repair Genes and Susceptibility to Prostate Cancer</title><title>Urology journal</title><addtitle>Urol J</addtitle><description>Mismatch repair (MMR) is one of the DNA repair systems that correct mispaired bases during DNA replication errors. Polymorphisms in genes can increase susceptibility to the development of prostate cancer (PCa). In this study, we investigated mutL homolog 1 (MLH1) -93G>A (rs1800734) and mutS homolog 3 (MSH3) (rs26279) polymorphisms with the risk of PCa.
In this study of Iranian population, 175 histopathologically confirmed (PCa) patients and 230 benign prostate hyperplasia (BPH) as the controls were recruited. The genotypes of MLH1 and MSH3 were determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method.
There was no significant difference of MLH1 (P = 0.4) and MSH3 (P?=?0.5) genotype distributions among PCa cases and controls. And also patients with PCa were not significant differences compared to those without in stage of cancer, grade of tumor, perineural invasion, and vascular invasion.
Our results did not show adequate evidence for any significant association of MLH1 and MSH3 polymorphisms and PCa .</description><subject>Aged</subject><subject>Case-Control Studies</subject><subject>DNA Mismatch Repair</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Iran</subject><subject>Male</subject><subject>Middle Aged</subject><subject>MutL Protein Homolog 1 - genetics</subject><subject>MutS Homolog 3 Protein - genetics</subject><subject>Polymorphism</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Yeast</subject><issn>1735-1308</issn><issn>1735-546X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNo10MFLwzAUBvAgipvTo1cJeO5M8po0PcrQKUwcTsFbSZuEZaxNTVJh_70V5-l7hx_f4z2ErimZM0aguBt282_iyJwTTk_QlBbAM56Lz9PjTIHICbqIcUdGAUScownQkoMEPkWbpelMcg1e-_2h9aHfuthib_HLmCo1W_xmeuUC_nURq07jzRAb0ydXu71LB5w8Xgcfk0oGL1TXmHCJzqzaR3N1zBn6eHx4Xzxlq9fl8-J-lfUMypRBA1xJIUVJSlnnSisQuRLS2kILRoSlhZYi16QuCgaCWV3mDYeR6NpQamGGbv96--C_BhNTtfND6MaVFZPjhUTyUozq5qiGujW66oNrVThU_z-AH2cbXcQ</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Khooshemehri, Paniz</creator><creator>Jamaldini, Seyed Hamid</creator><creator>Ziaee, Seyed Amir Mohsen</creator><creator>Afshari, Mahdi</creator><creator>Sattari, Mahshid</creator><creator>Narouie, Behzad</creator><creator>Sotoudeh, Mehdi</creator><creator>Montazeri, Vahideh</creator><creator>Sarhangi, Negar</creator><creator>Hasanzad, Mandana</creator><general>Urology and Nephrology Research Center</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20200501</creationdate><title>Genetic Polymorphism of Mismatch Repair Genes and Susceptibility to Prostate Cancer</title><author>Khooshemehri, Paniz ; 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Polymorphisms in genes can increase susceptibility to the development of prostate cancer (PCa). In this study, we investigated mutL homolog 1 (MLH1) -93G>A (rs1800734) and mutS homolog 3 (MSH3) (rs26279) polymorphisms with the risk of PCa.
In this study of Iranian population, 175 histopathologically confirmed (PCa) patients and 230 benign prostate hyperplasia (BPH) as the controls were recruited. The genotypes of MLH1 and MSH3 were determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method.
There was no significant difference of MLH1 (P = 0.4) and MSH3 (P?=?0.5) genotype distributions among PCa cases and controls. And also patients with PCa were not significant differences compared to those without in stage of cancer, grade of tumor, perineural invasion, and vascular invasion.
Our results did not show adequate evidence for any significant association of MLH1 and MSH3 polymorphisms and PCa .</abstract><cop>Iran</cop><pub>Urology and Nephrology Research Center</pub><pmid>31953835</pmid><doi>10.22037/uj.v0i0.5051</doi></addata></record> |
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| subjects | Aged Case-Control Studies DNA Mismatch Repair Genetic Predisposition to Disease Humans Iran Male Middle Aged MutL Protein Homolog 1 - genetics MutS Homolog 3 Protein - genetics Polymorphism Polymorphism, Restriction Fragment Length Prostate cancer Prostatic Neoplasms - genetics Yeast |
| title | Genetic Polymorphism of Mismatch Repair Genes and Susceptibility to Prostate Cancer |
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