Evaluation of Secondary Metabolites of Ageratina adenophora and Synthesis of Silver Nanoparticles for its Antibacterial and Antioxidant Activity
Synthetic antibiotics have been successfully utilized for decades against pathogenic bacteria to control infectious diseases. However, the continuous and overuse has resulted in multidrug resistant (MDR) bacterial species. Further, the negative side effects caused by commercial antibiotics also hind...
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Veröffentlicht in: | Oriental journal of chemistry 2023-01, Vol.39 (1), p.102-113 |
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creator | Maheswari B, Latha Mani N, Mani N Kavikala N, Kavikala N Karthika S, Karthika S Rajasudha V, Rajasudha V |
description | Synthetic antibiotics have been successfully utilized for decades against pathogenic bacteria to control infectious diseases. However, the continuous and overuse has resulted in multidrug resistant (MDR) bacterial species. Further, the negative side effects caused by commercial antibiotics also hindered their usage. The phytochemicals produced by plants in response to adverse biotic and abiotic conditions possess significant pharmacological properties and can be an effective alternative to synthetic antibiotics. The phytochemicals of Ageratinaadenophora, served the role of reducing and stabilizing agent. Ageratinaadenophora mediated silver nanoparticles (Aa-AgNPs) were characterized using advanced spectroscopic instrumentation. The qualitative analysis by GC-MS showed Methyl ionone, 2(3H)-Naphthalenone, 4, 4a, 5, 6, 7, 8- hexahydro-4a,7,7-trimethyl-(R), Isolongifolone as the major compounds. The quantitative estimation showed leaves were rich in total phenol, flavonoids, alkaloids and tannins. The Aa-AgNPs were effective in inhibiting bacterial pathogens. Further, A.adenophora mediated nanoparticles possessed strong antioxidant activity. |
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However, the continuous and overuse has resulted in multidrug resistant (MDR) bacterial species. Further, the negative side effects caused by commercial antibiotics also hindered their usage. The phytochemicals produced by plants in response to adverse biotic and abiotic conditions possess significant pharmacological properties and can be an effective alternative to synthetic antibiotics. The phytochemicals of Ageratinaadenophora, served the role of reducing and stabilizing agent. Ageratinaadenophora mediated silver nanoparticles (Aa-AgNPs) were characterized using advanced spectroscopic instrumentation. The qualitative analysis by GC-MS showed Methyl ionone, 2(3H)-Naphthalenone, 4, 4a, 5, 6, 7, 8- hexahydro-4a,7,7-trimethyl-(R), Isolongifolone as the major compounds. The quantitative estimation showed leaves were rich in total phenol, flavonoids, alkaloids and tannins. The Aa-AgNPs were effective in inhibiting bacterial pathogens. 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subjects | Antibiotics Antioxidants Bacteria Bacterial infections Biological activity E coli Flavonoids Free radicals Herbal medicine Hydrocarbons Infectious diseases Investigations Metabolites Microorganisms Nanoparticles Pathogens Phenols Phytochemicals Qualitative analysis Side effects Silver Solvents Stabilizers (agents) Streptococcus infections |
title | Evaluation of Secondary Metabolites of Ageratina adenophora and Synthesis of Silver Nanoparticles for its Antibacterial and Antioxidant Activity |
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