Role of ultrasonographic measurement of the fetal epicardial fat pad and cardiac interventricular septal thickness in predicting the outcome and prevent various complications of gestational diabetes mellitus
Background Gestational diabetes mellitus (GDM) is one of the most common medical conditions affecting pregnancy and increasing the risk for maternal and perinatal complications. The present study aimed at determining the role of ultrasonographic measurement of fetal epicardial fat pad thickness (f E...
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| Veröffentlicht in: | Egyptian Journal of Radiology and Nuclear Medicine 2023-12, Vol.54 (1), p.91-7, Article 91 |
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| creator | Ghuman, Gurnoor Kaur Bagri, Neha Chandra, Ranjan Malik, Amita Misra, Ritu Gaikwad, Harsha S. |
| description | Background
Gestational diabetes mellitus (GDM) is one of the most common medical conditions affecting pregnancy and increasing the risk for maternal and perinatal complications. The present study aimed at determining the role of ultrasonographic measurement of fetal epicardial fat pad thickness (f EFT) and fetal cardiac interventricular septal thickness (f IVST) at 24–32 weeks of gestation in the prediction of GDM.
Results
A prospective observational case–control study was conducted including a total of 35 GDM patients and 35 normal pregnancies who were subjected to ultrasonographic measurement of the f EFT and f IVST at 24–32 weeks of gestation. Statistical analysis and the receiver operating characteristic curves were used to find out the cutoff value, sensitivity, specificity and diagnostic accuracy of these two parameters for the prediction of GDM. When an f EFT value of 1.3 was accepted as a cutoff value, GDM could be predicted with a sensitivity of 68.6% and specificity of 91.4%, PPV of 88.9%, NPV of 74.4% and diagnostic accuracy of 80%. When an f IVST value of 2.6 was accepted as a cutoff value, GDM could be predicted with a sensitivity of 80%, specificity of 77.14%, PPV of 77.8%, NPV of 79.4% and diagnostic accuracy of 78.5%.
Conclusion
The ultrasonographic measurements of fetal epicardial fat pad thickness and fetal cardiac interventricular septal thickness were statistically significantly higher in GDM pregnancies (
p
value |
| doi_str_mv | 10.1186/s43055-023-01037-6 |
| format | Article |
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Gestational diabetes mellitus (GDM) is one of the most common medical conditions affecting pregnancy and increasing the risk for maternal and perinatal complications. The present study aimed at determining the role of ultrasonographic measurement of fetal epicardial fat pad thickness (f EFT) and fetal cardiac interventricular septal thickness (f IVST) at 24–32 weeks of gestation in the prediction of GDM.
Results
A prospective observational case–control study was conducted including a total of 35 GDM patients and 35 normal pregnancies who were subjected to ultrasonographic measurement of the f EFT and f IVST at 24–32 weeks of gestation. Statistical analysis and the receiver operating characteristic curves were used to find out the cutoff value, sensitivity, specificity and diagnostic accuracy of these two parameters for the prediction of GDM. When an f EFT value of 1.3 was accepted as a cutoff value, GDM could be predicted with a sensitivity of 68.6% and specificity of 91.4%, PPV of 88.9%, NPV of 74.4% and diagnostic accuracy of 80%. When an f IVST value of 2.6 was accepted as a cutoff value, GDM could be predicted with a sensitivity of 80%, specificity of 77.14%, PPV of 77.8%, NPV of 79.4% and diagnostic accuracy of 78.5%.
Conclusion
The ultrasonographic measurements of fetal epicardial fat pad thickness and fetal cardiac interventricular septal thickness were statistically significantly higher in GDM pregnancies (
p
value < 0.0001) as compared to the controls. Thus, these two parameters can serve as excellent ultrasonographic markers in the prediction of GDM.</description><identifier>ISSN: 2090-4762</identifier><identifier>ISSN: 0378-603X</identifier><identifier>EISSN: 2090-4762</identifier><identifier>DOI: 10.1186/s43055-023-01037-6</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Amniotic fluid ; Cardiovascular disease ; Complications and side effects ; Congenital diseases ; Epicardial fat pad thickness ; Fetal ; Fetuses ; Gestational age ; Gestational diabetes ; Gestational diabetes mellitus ; Glucose ; Hyperglycemia ; Imaging ; Insulin resistance ; Interventional Radiology ; Interventricular septal thickness ; Measurement ; Medicine ; Medicine & Public Health ; Metabolism ; Nuclear Medicine ; Pregnancy ; Prevention ; Radiology ; Type 2 diabetes ; Ultrasonic imaging ; Womens health</subject><ispartof>Egyptian Journal of Radiology and Nuclear Medicine, 2023-12, Vol.54 (1), p.91-7, Article 91</ispartof><rights>The Author(s) 2023</rights><rights>COPYRIGHT 2023 Springer</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c447t-d81c77fa532da9de63d4f13e94e9f099147c7b855f6f6c427915ee399f6003883</cites><orcidid>0000-0002-4883-1300</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27923,27924</link.rule.ids></links><search><creatorcontrib>Ghuman, Gurnoor Kaur</creatorcontrib><creatorcontrib>Bagri, Neha</creatorcontrib><creatorcontrib>Chandra, Ranjan</creatorcontrib><creatorcontrib>Malik, Amita</creatorcontrib><creatorcontrib>Misra, Ritu</creatorcontrib><creatorcontrib>Gaikwad, Harsha S.</creatorcontrib><title>Role of ultrasonographic measurement of the fetal epicardial fat pad and cardiac interventricular septal thickness in predicting the outcome and prevent various complications of gestational diabetes mellitus</title><title>Egyptian Journal of Radiology and Nuclear Medicine</title><addtitle>Egypt J Radiol Nucl Med</addtitle><description>Background
Gestational diabetes mellitus (GDM) is one of the most common medical conditions affecting pregnancy and increasing the risk for maternal and perinatal complications. The present study aimed at determining the role of ultrasonographic measurement of fetal epicardial fat pad thickness (f EFT) and fetal cardiac interventricular septal thickness (f IVST) at 24–32 weeks of gestation in the prediction of GDM.
Results
A prospective observational case–control study was conducted including a total of 35 GDM patients and 35 normal pregnancies who were subjected to ultrasonographic measurement of the f EFT and f IVST at 24–32 weeks of gestation. Statistical analysis and the receiver operating characteristic curves were used to find out the cutoff value, sensitivity, specificity and diagnostic accuracy of these two parameters for the prediction of GDM. When an f EFT value of 1.3 was accepted as a cutoff value, GDM could be predicted with a sensitivity of 68.6% and specificity of 91.4%, PPV of 88.9%, NPV of 74.4% and diagnostic accuracy of 80%. When an f IVST value of 2.6 was accepted as a cutoff value, GDM could be predicted with a sensitivity of 80%, specificity of 77.14%, PPV of 77.8%, NPV of 79.4% and diagnostic accuracy of 78.5%.
Conclusion
The ultrasonographic measurements of fetal epicardial fat pad thickness and fetal cardiac interventricular septal thickness were statistically significantly higher in GDM pregnancies (
p
value < 0.0001) as compared to the controls. Thus, these two parameters can serve as excellent ultrasonographic markers in the prediction of GDM.</description><subject>Amniotic fluid</subject><subject>Cardiovascular disease</subject><subject>Complications and side effects</subject><subject>Congenital diseases</subject><subject>Epicardial fat pad thickness</subject><subject>Fetal</subject><subject>Fetuses</subject><subject>Gestational age</subject><subject>Gestational diabetes</subject><subject>Gestational diabetes mellitus</subject><subject>Glucose</subject><subject>Hyperglycemia</subject><subject>Imaging</subject><subject>Insulin resistance</subject><subject>Interventional Radiology</subject><subject>Interventricular septal thickness</subject><subject>Measurement</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Nuclear Medicine</subject><subject>Pregnancy</subject><subject>Prevention</subject><subject>Radiology</subject><subject>Type 2 diabetes</subject><subject>Ultrasonic imaging</subject><subject>Womens health</subject><issn>2090-4762</issn><issn>0378-603X</issn><issn>2090-4762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNp9Ustq3TAQNaWFhiQ_0JWga6d6WbKWIfQRCARKuha60sjRrW25khzoV_aXKl-XpoVSaSFp5pwzM-g0zRuCrwjpxbvMGe66FlPWYoKZbMWL5oxihVsuBX35x_11c5nzEdfFMSaCnzU_PscRUPRoHUsyOc5xSGZ5DBZNYPKaYIK5bPnyCMhDMSOCJViTXKhXbwpajENmdmiPWRTmAumpslKw62gSyrBstFJFv86Qc0WgJYELtoR5OAnHtdg4wUmnpjY2ejIpxDWjmljGWrGEOOetkwFyOb2qaK14gAK5djuOoaz5onnlzZjh8td53nz58P7h5lN7d__x9ub6rrWcy9K6nlgpvekYdUY5EMxxTxgoDspjpQiXVh76rvPCC8upVKQDYEp5gTHre3be3O66LpqjXlKYTPquown6FIhp0CaVYEfQtYQTXPZeYs_9gRvmJSOGCiMpc-5Qtd7uWkuK39Y6nT7GNdXxsqY9kbSniotn1GCqaJh9rB9mp5CtvpYdpj2TYkNd_QNVt4Mp2DiDDzX-F4HuBJtizgn872EI1pu99G4vXe2lT_bSG4ntpFzB8wDpueP_sH4COk7Wvw</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Ghuman, Gurnoor Kaur</creator><creator>Bagri, Neha</creator><creator>Chandra, Ranjan</creator><creator>Malik, Amita</creator><creator>Misra, Ritu</creator><creator>Gaikwad, Harsha S.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-4883-1300</orcidid></search><sort><creationdate>20231201</creationdate><title>Role of ultrasonographic measurement of the fetal epicardial fat pad and cardiac interventricular septal thickness in predicting the outcome and prevent various complications of gestational diabetes mellitus</title><author>Ghuman, Gurnoor Kaur ; Bagri, Neha ; Chandra, Ranjan ; Malik, Amita ; Misra, Ritu ; Gaikwad, Harsha S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-d81c77fa532da9de63d4f13e94e9f099147c7b855f6f6c427915ee399f6003883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Amniotic fluid</topic><topic>Cardiovascular disease</topic><topic>Complications and side effects</topic><topic>Congenital diseases</topic><topic>Epicardial fat pad thickness</topic><topic>Fetal</topic><topic>Fetuses</topic><topic>Gestational age</topic><topic>Gestational diabetes</topic><topic>Gestational diabetes mellitus</topic><topic>Glucose</topic><topic>Hyperglycemia</topic><topic>Imaging</topic><topic>Insulin resistance</topic><topic>Interventional Radiology</topic><topic>Interventricular septal thickness</topic><topic>Measurement</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Nuclear Medicine</topic><topic>Pregnancy</topic><topic>Prevention</topic><topic>Radiology</topic><topic>Type 2 diabetes</topic><topic>Ultrasonic imaging</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghuman, Gurnoor Kaur</creatorcontrib><creatorcontrib>Bagri, Neha</creatorcontrib><creatorcontrib>Chandra, Ranjan</creatorcontrib><creatorcontrib>Malik, Amita</creatorcontrib><creatorcontrib>Misra, Ritu</creatorcontrib><creatorcontrib>Gaikwad, Harsha S.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Egyptian Journal of Radiology and Nuclear Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghuman, Gurnoor Kaur</au><au>Bagri, Neha</au><au>Chandra, Ranjan</au><au>Malik, Amita</au><au>Misra, Ritu</au><au>Gaikwad, Harsha S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of ultrasonographic measurement of the fetal epicardial fat pad and cardiac interventricular septal thickness in predicting the outcome and prevent various complications of gestational diabetes mellitus</atitle><jtitle>Egyptian Journal of Radiology and Nuclear Medicine</jtitle><stitle>Egypt J Radiol Nucl Med</stitle><date>2023-12-01</date><risdate>2023</risdate><volume>54</volume><issue>1</issue><spage>91</spage><epage>7</epage><pages>91-7</pages><artnum>91</artnum><issn>2090-4762</issn><issn>0378-603X</issn><eissn>2090-4762</eissn><abstract>Background
Gestational diabetes mellitus (GDM) is one of the most common medical conditions affecting pregnancy and increasing the risk for maternal and perinatal complications. The present study aimed at determining the role of ultrasonographic measurement of fetal epicardial fat pad thickness (f EFT) and fetal cardiac interventricular septal thickness (f IVST) at 24–32 weeks of gestation in the prediction of GDM.
Results
A prospective observational case–control study was conducted including a total of 35 GDM patients and 35 normal pregnancies who were subjected to ultrasonographic measurement of the f EFT and f IVST at 24–32 weeks of gestation. Statistical analysis and the receiver operating characteristic curves were used to find out the cutoff value, sensitivity, specificity and diagnostic accuracy of these two parameters for the prediction of GDM. When an f EFT value of 1.3 was accepted as a cutoff value, GDM could be predicted with a sensitivity of 68.6% and specificity of 91.4%, PPV of 88.9%, NPV of 74.4% and diagnostic accuracy of 80%. When an f IVST value of 2.6 was accepted as a cutoff value, GDM could be predicted with a sensitivity of 80%, specificity of 77.14%, PPV of 77.8%, NPV of 79.4% and diagnostic accuracy of 78.5%.
Conclusion
The ultrasonographic measurements of fetal epicardial fat pad thickness and fetal cardiac interventricular septal thickness were statistically significantly higher in GDM pregnancies (
p
value < 0.0001) as compared to the controls. Thus, these two parameters can serve as excellent ultrasonographic markers in the prediction of GDM.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s43055-023-01037-6</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-4883-1300</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Amniotic fluid Cardiovascular disease Complications and side effects Congenital diseases Epicardial fat pad thickness Fetal Fetuses Gestational age Gestational diabetes Gestational diabetes mellitus Glucose Hyperglycemia Imaging Insulin resistance Interventional Radiology Interventricular septal thickness Measurement Medicine Medicine & Public Health Metabolism Nuclear Medicine Pregnancy Prevention Radiology Type 2 diabetes Ultrasonic imaging Womens health |
| title | Role of ultrasonographic measurement of the fetal epicardial fat pad and cardiac interventricular septal thickness in predicting the outcome and prevent various complications of gestational diabetes mellitus |
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