Neuro-COVID-19 With or Without the Multisystem Inflammatory Syndrome (MIS-C): A Single-Center Study
This study evaluates the range of neurological manifestation in children with COVID-19 (neuro-COVID-19) both with and without the multisystem inflammatory syndrome (MIS-C) and the persistence of symptoms after hospital discharge. The study was conducted as a prospective study of children and adolesc...
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| Veröffentlicht in: | Journal of molecular neuroscience 2023-05, Vol.73 (4-5), p.250-258 |
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| creator | Bentes, Aline Almeida dos Santos Junior, Walter Rebuite Pessoa, Natalia Lima Costa, Thais Alkifeles Oliveira, Gabriela Fernanda Garcia Diniz, Lilian Martins Oliveira Torres, Bruna Ribeiro Teixeira, Daniela Caldas Mendes, Renata Barandas Avelar, Ana Beatriz Alvim Campos, Marco Antônio Kroon, Erna Geessien Drumond, Betania Paiva |
| description | This study evaluates the range of neurological manifestation in children with COVID-19 (neuro-COVID-19) both with and without the multisystem inflammatory syndrome (MIS-C) and the persistence of symptoms after hospital discharge. The study was conducted as a prospective study of children and adolescents under 18 years of age who were admitted to a children’s hospital for infectious diseases from January 2021 to January 2022. The children had no previous neurological or psychiatric disorders. Out of the 3021 patients evaluated, 232 were confirmed to have COVID-19 and 21 of these patients (9%) showed neurological manifestations associated with the virus. Of these 21 patients, 14 developed MIS-C, and 7 had neurological manifestations unrelated to MIS-C. There was no statistical difference regarding the neurological manifestations during hospitalization and outcomes between patients with neuro-COVID-19 who had or did not have MIS-C, except for seizures that occurred more frequently in patients with neuro-COVID-19 without MIS-C (p-value = 0.0263). One patient died, and 5 patients still had neurological or psychiatric manifestations at discharge, which persisted for up to 7 months. The study highlights that SARS-CoV-2 infection can affect the central and peripheral nervous system, particularly in children and adolescents with MIS-C, and that it is crucial to be vigilant for long-term adverse outcomes, as the neurological and psychiatric effects of COVID-19 in children are emerging during an important stage of brain development. |
| doi_str_mv | 10.1007/s12031-023-02109-y |
| format | Article |
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The study was conducted as a prospective study of children and adolescents under 18 years of age who were admitted to a children’s hospital for infectious diseases from January 2021 to January 2022. The children had no previous neurological or psychiatric disorders. Out of the 3021 patients evaluated, 232 were confirmed to have COVID-19 and 21 of these patients (9%) showed neurological manifestations associated with the virus. Of these 21 patients, 14 developed MIS-C, and 7 had neurological manifestations unrelated to MIS-C. There was no statistical difference regarding the neurological manifestations during hospitalization and outcomes between patients with neuro-COVID-19 who had or did not have MIS-C, except for seizures that occurred more frequently in patients with neuro-COVID-19 without MIS-C (p-value = 0.0263). One patient died, and 5 patients still had neurological or psychiatric manifestations at discharge, which persisted for up to 7 months. The study highlights that SARS-CoV-2 infection can affect the central and peripheral nervous system, particularly in children and adolescents with MIS-C, and that it is crucial to be vigilant for long-term adverse outcomes, as the neurological and psychiatric effects of COVID-19 in children are emerging during an important stage of brain development.</description><identifier>ISSN: 0895-8696</identifier><identifier>EISSN: 1559-1166</identifier><identifier>DOI: 10.1007/s12031-023-02109-y</identifier><language>eng</language><publisher>Totowa: Springer Nature B.V</publisher><subject>Adolescents ; Children ; Coronaviruses ; COVID-19 ; Developmental stages ; Infectious diseases ; Inflammation ; Mental disorders ; Nervous system ; Neurological diseases ; Peripheral nervous system ; Seizures ; Severe acute respiratory syndrome coronavirus 2 ; Signs and symptoms ; Viral diseases ; Viruses</subject><ispartof>Journal of molecular neuroscience, 2023-05, Vol.73 (4-5), p.250-258</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c121y-ebb948aac6f6133f7063d2af6c5547eb127e3775c79d0f84cf82ed2b902982013</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Bentes, Aline Almeida</creatorcontrib><creatorcontrib>dos Santos Junior, Walter Rebuite</creatorcontrib><creatorcontrib>Pessoa, Natalia Lima</creatorcontrib><creatorcontrib>Costa, Thais Alkifeles</creatorcontrib><creatorcontrib>Oliveira, Gabriela Fernanda Garcia</creatorcontrib><creatorcontrib>Diniz, Lilian Martins Oliveira</creatorcontrib><creatorcontrib>Torres, Bruna Ribeiro</creatorcontrib><creatorcontrib>Teixeira, Daniela Caldas</creatorcontrib><creatorcontrib>Mendes, Renata Barandas</creatorcontrib><creatorcontrib>Avelar, Ana Beatriz Alvim</creatorcontrib><creatorcontrib>Campos, Marco Antônio</creatorcontrib><creatorcontrib>Kroon, Erna Geessien</creatorcontrib><creatorcontrib>Drumond, Betania Paiva</creatorcontrib><title>Neuro-COVID-19 With or Without the Multisystem Inflammatory Syndrome (MIS-C): A Single-Center Study</title><title>Journal of molecular neuroscience</title><description>This study evaluates the range of neurological manifestation in children with COVID-19 (neuro-COVID-19) both with and without the multisystem inflammatory syndrome (MIS-C) and the persistence of symptoms after hospital discharge. 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| subjects | Adolescents Children Coronaviruses COVID-19 Developmental stages Infectious diseases Inflammation Mental disorders Nervous system Neurological diseases Peripheral nervous system Seizures Severe acute respiratory syndrome coronavirus 2 Signs and symptoms Viral diseases Viruses |
| title | Neuro-COVID-19 With or Without the Multisystem Inflammatory Syndrome (MIS-C): A Single-Center Study |
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