A 1.1 Mb duplication CNV on chromosome 17 contributes to skeletal muscle development in Boer goats
The Boer goat is one of the top meat breeds in modern animal husbandry and has attracted widespread attention for its unique growth performance. However, the genetic basis of muscle development in the Boer goat remains obscure. In this study, we identified specific structural variants in the Boer go...
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| Veröffentlicht in: | Dōngwùxué yánjiū 2023-03, Vol.44 (2), p.303-314 |
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| creator | Yuan, Ying Zhang, Wei-Yi Yang, Bai-Gao Zhou, Dong-Ke Xu, Lu He, Yong-Meng Zhang, Hao-Yuan Liu, Cheng-Li Ma, Yue-Hui Chu, Ming-Xing Zhang, Wen-Guang Gao, Hui-Jiang Jiang, Lin Zhao, Fu-Ping Zhang, Lu-Pei Na, Ri-Su Oyungerel, Baatarchogt Han, Yan-Guo Zeng, Yan Wang, Shi-Zhi Jiang, Huai-Zhi Zhang, Hong-Ping Jiang, Xun-Ping He, Jian-Ning Liang, Hao Kaushalendra, Kaushalendra Sun, Ya-Wang Huang, Yong-Fu Zhao, Yong-Ju Zhao, Zhong-Quan E, Guang-Xin |
| description | The Boer goat is one of the top meat breeds in modern animal husbandry and has attracted widespread attention for its unique growth performance. However, the genetic basis of muscle development in the Boer goat remains obscure. In this study, we identified specific structural variants in the Boer goat based on genome-wide selection signals and analyzed the basis of the molecular heredity of related candidate genes in muscle development. A total of 9 959 autosomal copy number variations (CNVs) were identified through selection signal analysis in 127 goat genomes. Specifically, we confirmed that the highest signal CNV (HSV) was a chromosomal arrangement containing an approximately 1.11 Mb (CHIR17: 60062304-61171840 bp) duplicated fragment inserted in reverse orientation and a 5 362 bp deleted region (CHIR17:60145940-60151302 bp) with overlapping genes (e.g.,
,
,
,
, and
). The homozygous duplicated HSV genotype (+/+) was found in 96% of Boer goats but was not detected in Eurasian goats and was only detected in 4% of indigenous African goats. The expression network of three candidate genes (
,
, and
) regulating dose transcription was constructed by RNA sequencing. Results indicated that these genes were involved in the proliferation and differentiation of skeletal muscle satellite cells (SMSCs) and their overexpression significantly increased the expression of
. The HSV of the Boer goat contributed to superior skeletal muscle growth via the dose effects of overlapping genes. |
| doi_str_mv | 10.24272/j.issn.2095-8137.2022.384 |
| format | Article |
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However, the genetic basis of muscle development in the Boer goat remains obscure. In this study, we identified specific structural variants in the Boer goat based on genome-wide selection signals and analyzed the basis of the molecular heredity of related candidate genes in muscle development. A total of 9 959 autosomal copy number variations (CNVs) were identified through selection signal analysis in 127 goat genomes. Specifically, we confirmed that the highest signal CNV (HSV) was a chromosomal arrangement containing an approximately 1.11 Mb (CHIR17: 60062304-61171840 bp) duplicated fragment inserted in reverse orientation and a 5 362 bp deleted region (CHIR17:60145940-60151302 bp) with overlapping genes (e.g.,
,
,
,
, and
). The homozygous duplicated HSV genotype (+/+) was found in 96% of Boer goats but was not detected in Eurasian goats and was only detected in 4% of indigenous African goats. The expression network of three candidate genes (
,
, and
) regulating dose transcription was constructed by RNA sequencing. Results indicated that these genes were involved in the proliferation and differentiation of skeletal muscle satellite cells (SMSCs) and their overexpression significantly increased the expression of
. The HSV of the Boer goat contributed to superior skeletal muscle growth via the dose effects of overlapping genes.</description><identifier>ISSN: 2095-8137</identifier><identifier>ISSN: 0254-5853</identifier><identifier>DOI: 10.24272/j.issn.2095-8137.2022.384</identifier><identifier>PMID: 36785897</identifier><language>eng</language><publisher>China: Kunming Institute of Zoology, The Chinese Academy of Sciences</publisher><subject>Animal husbandry ; Animals ; Annealing ; Cell differentiation ; Cell proliferation ; Cells (biology) ; Chromosome 17 ; Chromosomes ; Chromosomes, Human, Pair 17 ; Copy number ; DNA Copy Number Variations ; Gene duplication ; Gene sequencing ; Genes ; Genetic testing ; Genetics ; Genome ; Genomes ; Genotypes ; Goats ; Goats - genetics ; Heredity ; Humans ; Muscle Development ; Muscles ; Musculoskeletal system ; Proliferation ; Reproduction (copying) ; RNA sequencing ; Satellite cells ; Signal analysis ; Skeletal muscle ; Transcription</subject><ispartof>Dōngwùxué yánjiū, 2023-03, Vol.44 (2), p.303-314</ispartof><rights>Copyright Kunming Institute of Zoology, The Chinese Academy of Sciences Mar 2023</rights><rights>2023 Editorial Office of Zoological Research, Kunming Institute of Zoology, Chinese Academy of Sciences</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-920888fa3a4cb808ee723c7ebc779d9657d3904cbe4d301cdf52fdb4a5f1b393</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36785897$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yuan, Ying</creatorcontrib><creatorcontrib>Zhang, Wei-Yi</creatorcontrib><creatorcontrib>Yang, Bai-Gao</creatorcontrib><creatorcontrib>Zhou, Dong-Ke</creatorcontrib><creatorcontrib>Xu, Lu</creatorcontrib><creatorcontrib>He, Yong-Meng</creatorcontrib><creatorcontrib>Zhang, Hao-Yuan</creatorcontrib><creatorcontrib>Liu, Cheng-Li</creatorcontrib><creatorcontrib>Ma, Yue-Hui</creatorcontrib><creatorcontrib>Chu, Ming-Xing</creatorcontrib><creatorcontrib>Zhang, Wen-Guang</creatorcontrib><creatorcontrib>Gao, Hui-Jiang</creatorcontrib><creatorcontrib>Jiang, Lin</creatorcontrib><creatorcontrib>Zhao, Fu-Ping</creatorcontrib><creatorcontrib>Zhang, Lu-Pei</creatorcontrib><creatorcontrib>Na, Ri-Su</creatorcontrib><creatorcontrib>Oyungerel, Baatarchogt</creatorcontrib><creatorcontrib>Han, Yan-Guo</creatorcontrib><creatorcontrib>Zeng, Yan</creatorcontrib><creatorcontrib>Wang, Shi-Zhi</creatorcontrib><creatorcontrib>Jiang, Huai-Zhi</creatorcontrib><creatorcontrib>Zhang, Hong-Ping</creatorcontrib><creatorcontrib>Jiang, Xun-Ping</creatorcontrib><creatorcontrib>He, Jian-Ning</creatorcontrib><creatorcontrib>Liang, Hao</creatorcontrib><creatorcontrib>Kaushalendra, Kaushalendra</creatorcontrib><creatorcontrib>Sun, Ya-Wang</creatorcontrib><creatorcontrib>Huang, Yong-Fu</creatorcontrib><creatorcontrib>Zhao, Yong-Ju</creatorcontrib><creatorcontrib>Zhao, Zhong-Quan</creatorcontrib><creatorcontrib>E, Guang-Xin</creatorcontrib><creatorcontrib>Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China</creatorcontrib><creatorcontrib>蒙古生命科学大学动物科学与生物技术学院, 乌兰巴托 17024, 蒙古</creatorcontrib><creatorcontrib>Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China</creatorcontrib><creatorcontrib>内蒙古农业大学动物科学学院, 内蒙古 呼和浩特 010018, 中国</creatorcontrib><creatorcontrib>重庆市草食家畜重点实验室, 重庆 400715, 中国</creatorcontrib><creatorcontrib>吉林农业大学动物科学技术学院, 吉林 长春 130118, 中国</creatorcontrib><creatorcontrib>Animal Science and Technology College, Jilin Agriculture University, Changchun, Jilin 130118, China</creatorcontrib><creatorcontrib>Chongqing Key Laboratory of Forage & Herbivore, Chongqing 400715, China</creatorcontrib><creatorcontrib>College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, Shandong 266109, China</creatorcontrib><creatorcontrib>青岛农业大学动物科技学院, 山东 青岛266109, 中国</creatorcontrib><creatorcontrib>内蒙古大学生命科学学院&草地家畜繁殖调控与繁殖国家重点实验室, 内蒙古 呼和浩特010070, 中国</creatorcontrib><creatorcontrib>中国农业科学院北京畜牧兽医研究所, 北京 100193, 中国</creatorcontrib><creatorcontrib>西南大学动物科学技术学院, 重庆400715, 中国</creatorcontrib><creatorcontrib>Key Lab of Agricultural Animal, Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong, Agricultural University, Wuhan, Hubei 430070, China</creatorcontrib><creatorcontrib>State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, Inner Mongolia 010070, China</creatorcontrib><creatorcontrib>College of Animal Science and Technology, Southwest University, Chongqing 400715, China</creatorcontrib><creatorcontrib>Department of Zoology, Pachhunga University College, Mizoram University, Aizawl 796001, India</creatorcontrib><creatorcontrib>四川农业大学动物科技学院&四川省家畜遗传资源发掘与创新重点实验室, 四川 成都 611130, 中国</creatorcontrib><creatorcontrib>米佐拉姆大学动物学系, 艾藻尔796001, 印度</creatorcontrib><creatorcontrib>School of Animal Science & Biotechnology, Mongolian University of Life Sciences, Zaisan, Khan-uul, Ulaanbaatar 17024, Mongolia</creatorcontrib><creatorcontrib>华中农业大学动物科技学院农业动物遗传育种与繁殖教育部重点实验室, 湖北 武汉 430070, 中国</creatorcontrib><creatorcontrib>College of Animal Science, Inner Mongolia Agricultural University, Huhhot, Inner Mongolia 010018, China</creatorcontrib><title>A 1.1 Mb duplication CNV on chromosome 17 contributes to skeletal muscle development in Boer goats</title><title>Dōngwùxué yánjiū</title><addtitle>Zool Res</addtitle><description>The Boer goat is one of the top meat breeds in modern animal husbandry and has attracted widespread attention for its unique growth performance. However, the genetic basis of muscle development in the Boer goat remains obscure. In this study, we identified specific structural variants in the Boer goat based on genome-wide selection signals and analyzed the basis of the molecular heredity of related candidate genes in muscle development. A total of 9 959 autosomal copy number variations (CNVs) were identified through selection signal analysis in 127 goat genomes. Specifically, we confirmed that the highest signal CNV (HSV) was a chromosomal arrangement containing an approximately 1.11 Mb (CHIR17: 60062304-61171840 bp) duplicated fragment inserted in reverse orientation and a 5 362 bp deleted region (CHIR17:60145940-60151302 bp) with overlapping genes (e.g.,
,
,
,
, and
). The homozygous duplicated HSV genotype (+/+) was found in 96% of Boer goats but was not detected in Eurasian goats and was only detected in 4% of indigenous African goats. The expression network of three candidate genes (
,
, and
) regulating dose transcription was constructed by RNA sequencing. Results indicated that these genes were involved in the proliferation and differentiation of skeletal muscle satellite cells (SMSCs) and their overexpression significantly increased the expression of
. The HSV of the Boer goat contributed to superior skeletal muscle growth via the dose effects of overlapping genes.</description><subject>Animal husbandry</subject><subject>Animals</subject><subject>Annealing</subject><subject>Cell differentiation</subject><subject>Cell proliferation</subject><subject>Cells (biology)</subject><subject>Chromosome 17</subject><subject>Chromosomes</subject><subject>Chromosomes, Human, Pair 17</subject><subject>Copy number</subject><subject>DNA Copy Number Variations</subject><subject>Gene duplication</subject><subject>Gene sequencing</subject><subject>Genes</subject><subject>Genetic testing</subject><subject>Genetics</subject><subject>Genome</subject><subject>Genomes</subject><subject>Genotypes</subject><subject>Goats</subject><subject>Goats - genetics</subject><subject>Heredity</subject><subject>Humans</subject><subject>Muscle Development</subject><subject>Muscles</subject><subject>Musculoskeletal system</subject><subject>Proliferation</subject><subject>Reproduction (copying)</subject><subject>RNA sequencing</subject><subject>Satellite cells</subject><subject>Signal analysis</subject><subject>Skeletal muscle</subject><subject>Transcription</subject><issn>2095-8137</issn><issn>0254-5853</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkctuFDEQRb0AkSjkF5AFGzbT-Dl2s0FhxEsKsInYWra7OvHgbg-2O1L-HncSRsCqSlW3rm7pIPSSko4JptibfRdKmTtGernRlKvWMdZxLZ6g0-PwBJ2XEhyRrSeMbp-hE75VWupenSJ3gWlH8VeHh-UQg7c1pBnvvv3ArfibnKZU0gSYKuzTXHNwS4WCa8LlJ0SoNuJpKT4CHuAWYjpMMFccZvw-QcbXydbyHD0dbSxw_ljP0NXHD1e7z5vL75--7C4uN15IWTc9I1rr0XIrvNNEAyjGvQLnleqHfivVwHvSdiAGTqgfRsnGwQkrR-p4z8_Quwfbw-ImGHzLkW00hxwmm-9MssH8u5nDjblOt4YSojmjq8PrR4ecfi1QqplC8RCjnSEtxTCltrLpKGvSV_9J92nJc3vPME1FrwXToqnePqh8TqVkGI9pKDH3BM3erATNCsussMxK0PD74xd__3M8_cOO_waa6Zut</recordid><startdate>20230318</startdate><enddate>20230318</enddate><creator>Yuan, Ying</creator><creator>Zhang, Wei-Yi</creator><creator>Yang, Bai-Gao</creator><creator>Zhou, Dong-Ke</creator><creator>Xu, Lu</creator><creator>He, 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1.1 Mb duplication CNV on chromosome 17 contributes to skeletal muscle development in Boer goats</title><author>Yuan, Ying ; Zhang, Wei-Yi ; Yang, Bai-Gao ; Zhou, Dong-Ke ; Xu, Lu ; He, Yong-Meng ; Zhang, Hao-Yuan ; Liu, Cheng-Li ; Ma, Yue-Hui ; Chu, Ming-Xing ; Zhang, Wen-Guang ; Gao, Hui-Jiang ; Jiang, Lin ; Zhao, Fu-Ping ; Zhang, Lu-Pei ; Na, Ri-Su ; Oyungerel, Baatarchogt ; Han, Yan-Guo ; Zeng, Yan ; Wang, Shi-Zhi ; Jiang, Huai-Zhi ; Zhang, Hong-Ping ; Jiang, Xun-Ping ; He, Jian-Ning ; Liang, Hao ; Kaushalendra, Kaushalendra ; Sun, Ya-Wang ; Huang, Yong-Fu ; Zhao, Yong-Ju ; Zhao, Zhong-Quan ; E, Guang-Xin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-920888fa3a4cb808ee723c7ebc779d9657d3904cbe4d301cdf52fdb4a5f1b393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animal husbandry</topic><topic>Animals</topic><topic>Annealing</topic><topic>Cell differentiation</topic><topic>Cell proliferation</topic><topic>Cells (biology)</topic><topic>Chromosome 17</topic><topic>Chromosomes</topic><topic>Chromosomes, Human, Pair 17</topic><topic>Copy number</topic><topic>DNA Copy Number Variations</topic><topic>Gene duplication</topic><topic>Gene sequencing</topic><topic>Genes</topic><topic>Genetic testing</topic><topic>Genetics</topic><topic>Genome</topic><topic>Genomes</topic><topic>Genotypes</topic><topic>Goats</topic><topic>Goats - genetics</topic><topic>Heredity</topic><topic>Humans</topic><topic>Muscle Development</topic><topic>Muscles</topic><topic>Musculoskeletal system</topic><topic>Proliferation</topic><topic>Reproduction (copying)</topic><topic>RNA sequencing</topic><topic>Satellite cells</topic><topic>Signal analysis</topic><topic>Skeletal muscle</topic><topic>Transcription</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yuan, Ying</creatorcontrib><creatorcontrib>Zhang, Wei-Yi</creatorcontrib><creatorcontrib>Yang, Bai-Gao</creatorcontrib><creatorcontrib>Zhou, Dong-Ke</creatorcontrib><creatorcontrib>Xu, Lu</creatorcontrib><creatorcontrib>He, Yong-Meng</creatorcontrib><creatorcontrib>Zhang, Hao-Yuan</creatorcontrib><creatorcontrib>Liu, Cheng-Li</creatorcontrib><creatorcontrib>Ma, Yue-Hui</creatorcontrib><creatorcontrib>Chu, Ming-Xing</creatorcontrib><creatorcontrib>Zhang, Wen-Guang</creatorcontrib><creatorcontrib>Gao, Hui-Jiang</creatorcontrib><creatorcontrib>Jiang, Lin</creatorcontrib><creatorcontrib>Zhao, Fu-Ping</creatorcontrib><creatorcontrib>Zhang, Lu-Pei</creatorcontrib><creatorcontrib>Na, Ri-Su</creatorcontrib><creatorcontrib>Oyungerel, Baatarchogt</creatorcontrib><creatorcontrib>Han, Yan-Guo</creatorcontrib><creatorcontrib>Zeng, Yan</creatorcontrib><creatorcontrib>Wang, Shi-Zhi</creatorcontrib><creatorcontrib>Jiang, Huai-Zhi</creatorcontrib><creatorcontrib>Zhang, Hong-Ping</creatorcontrib><creatorcontrib>Jiang, Xun-Ping</creatorcontrib><creatorcontrib>He, Jian-Ning</creatorcontrib><creatorcontrib>Liang, Hao</creatorcontrib><creatorcontrib>Kaushalendra, Kaushalendra</creatorcontrib><creatorcontrib>Sun, Ya-Wang</creatorcontrib><creatorcontrib>Huang, Yong-Fu</creatorcontrib><creatorcontrib>Zhao, Yong-Ju</creatorcontrib><creatorcontrib>Zhao, Zhong-Quan</creatorcontrib><creatorcontrib>E, Guang-Xin</creatorcontrib><creatorcontrib>Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China</creatorcontrib><creatorcontrib>蒙古生命科学大学动物科学与生物技术学院, 乌兰巴托 17024, 蒙古</creatorcontrib><creatorcontrib>Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China</creatorcontrib><creatorcontrib>内蒙古农业大学动物科学学院, 内蒙古 呼和浩特 010018, 中国</creatorcontrib><creatorcontrib>重庆市草食家畜重点实验室, 重庆 400715, 中国</creatorcontrib><creatorcontrib>吉林农业大学动物科学技术学院, 吉林 长春 130118, 中国</creatorcontrib><creatorcontrib>Animal Science and Technology College, Jilin Agriculture University, Changchun, Jilin 130118, China</creatorcontrib><creatorcontrib>Chongqing Key Laboratory of Forage & Herbivore, Chongqing 400715, China</creatorcontrib><creatorcontrib>College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, Shandong 266109, China</creatorcontrib><creatorcontrib>青岛农业大学动物科技学院, 山东 青岛266109, 中国</creatorcontrib><creatorcontrib>内蒙古大学生命科学学院&草地家畜繁殖调控与繁殖国家重点实验室, 内蒙古 呼和浩特010070, 中国</creatorcontrib><creatorcontrib>中国农业科学院北京畜牧兽医研究所, 北京 100193, 中国</creatorcontrib><creatorcontrib>西南大学动物科学技术学院, 重庆400715, 中国</creatorcontrib><creatorcontrib>Key Lab of Agricultural Animal, Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong, Agricultural University, Wuhan, Hubei 430070, China</creatorcontrib><creatorcontrib>State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, Inner Mongolia 010070, China</creatorcontrib><creatorcontrib>College of Animal Science and Technology, Southwest University, Chongqing 400715, China</creatorcontrib><creatorcontrib>Department of Zoology, Pachhunga University College, Mizoram University, Aizawl 796001, India</creatorcontrib><creatorcontrib>四川农业大学动物科技学院&四川省家畜遗传资源发掘与创新重点实验室, 四川 成都 611130, 中国</creatorcontrib><creatorcontrib>米佐拉姆大学动物学系, 艾藻尔796001, 印度</creatorcontrib><creatorcontrib>School of Animal Science & Biotechnology, Mongolian University of Life Sciences, Zaisan, Khan-uul, Ulaanbaatar 17024, Mongolia</creatorcontrib><creatorcontrib>华中农业大学动物科技学院农业动物遗传育种与繁殖教育部重点实验室, 湖北 武汉 430070, 中国</creatorcontrib><creatorcontrib>College of Animal Science, Inner Mongolia Agricultural University, Huhhot, Inner Mongolia 010018, China</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>East & South Asia Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Dōngwùxué yánjiū</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuan, Ying</au><au>Zhang, Wei-Yi</au><au>Yang, Bai-Gao</au><au>Zhou, Dong-Ke</au><au>Xu, Lu</au><au>He, Yong-Meng</au><au>Zhang, Hao-Yuan</au><au>Liu, Cheng-Li</au><au>Ma, Yue-Hui</au><au>Chu, Ming-Xing</au><au>Zhang, Wen-Guang</au><au>Gao, Hui-Jiang</au><au>Jiang, Lin</au><au>Zhao, Fu-Ping</au><au>Zhang, Lu-Pei</au><au>Na, Ri-Su</au><au>Oyungerel, Baatarchogt</au><au>Han, Yan-Guo</au><au>Zeng, Yan</au><au>Wang, Shi-Zhi</au><au>Jiang, Huai-Zhi</au><au>Zhang, Hong-Ping</au><au>Jiang, Xun-Ping</au><au>He, Jian-Ning</au><au>Liang, Hao</au><au>Kaushalendra, Kaushalendra</au><au>Sun, Ya-Wang</au><au>Huang, Yong-Fu</au><au>Zhao, Yong-Ju</au><au>Zhao, Zhong-Quan</au><au>E, Guang-Xin</au><aucorp>Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China</aucorp><aucorp>蒙古生命科学大学动物科学与生物技术学院, 乌兰巴托 17024, 蒙古</aucorp><aucorp>Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China</aucorp><aucorp>内蒙古农业大学动物科学学院, 内蒙古 呼和浩特 010018, 中国</aucorp><aucorp>重庆市草食家畜重点实验室, 重庆 400715, 中国</aucorp><aucorp>吉林农业大学动物科学技术学院, 吉林 长春 130118, 中国</aucorp><aucorp>Animal Science and Technology College, Jilin Agriculture University, Changchun, Jilin 130118, China</aucorp><aucorp>Chongqing Key Laboratory of Forage & Herbivore, Chongqing 400715, China</aucorp><aucorp>College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, Shandong 266109, China</aucorp><aucorp>青岛农业大学动物科技学院, 山东 青岛266109, 中国</aucorp><aucorp>内蒙古大学生命科学学院&草地家畜繁殖调控与繁殖国家重点实验室, 内蒙古 呼和浩特010070, 中国</aucorp><aucorp>中国农业科学院北京畜牧兽医研究所, 北京 100193, 中国</aucorp><aucorp>西南大学动物科学技术学院, 重庆400715, 中国</aucorp><aucorp>Key Lab of Agricultural Animal, Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong, Agricultural University, Wuhan, Hubei 430070, China</aucorp><aucorp>State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, Inner Mongolia 010070, China</aucorp><aucorp>College of Animal Science and Technology, Southwest University, Chongqing 400715, China</aucorp><aucorp>Department of Zoology, Pachhunga University College, Mizoram University, Aizawl 796001, India</aucorp><aucorp>四川农业大学动物科技学院&四川省家畜遗传资源发掘与创新重点实验室, 四川 成都 611130, 中国</aucorp><aucorp>米佐拉姆大学动物学系, 艾藻尔796001, 印度</aucorp><aucorp>School of Animal Science & Biotechnology, Mongolian University of Life Sciences, Zaisan, Khan-uul, Ulaanbaatar 17024, Mongolia</aucorp><aucorp>华中农业大学动物科技学院农业动物遗传育种与繁殖教育部重点实验室, 湖北 武汉 430070, 中国</aucorp><aucorp>College of Animal Science, Inner Mongolia Agricultural University, Huhhot, Inner Mongolia 010018, China</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A 1.1 Mb duplication CNV on chromosome 17 contributes to skeletal muscle development in Boer goats</atitle><jtitle>Dōngwùxué yánjiū</jtitle><addtitle>Zool Res</addtitle><date>2023-03-18</date><risdate>2023</risdate><volume>44</volume><issue>2</issue><spage>303</spage><epage>314</epage><pages>303-314</pages><issn>2095-8137</issn><issn>0254-5853</issn><abstract>The Boer goat is one of the top meat breeds in modern animal husbandry and has attracted widespread attention for its unique growth performance. However, the genetic basis of muscle development in the Boer goat remains obscure. In this study, we identified specific structural variants in the Boer goat based on genome-wide selection signals and analyzed the basis of the molecular heredity of related candidate genes in muscle development. A total of 9 959 autosomal copy number variations (CNVs) were identified through selection signal analysis in 127 goat genomes. Specifically, we confirmed that the highest signal CNV (HSV) was a chromosomal arrangement containing an approximately 1.11 Mb (CHIR17: 60062304-61171840 bp) duplicated fragment inserted in reverse orientation and a 5 362 bp deleted region (CHIR17:60145940-60151302 bp) with overlapping genes (e.g.,
,
,
,
, and
). The homozygous duplicated HSV genotype (+/+) was found in 96% of Boer goats but was not detected in Eurasian goats and was only detected in 4% of indigenous African goats. The expression network of three candidate genes (
,
, and
) regulating dose transcription was constructed by RNA sequencing. Results indicated that these genes were involved in the proliferation and differentiation of skeletal muscle satellite cells (SMSCs) and their overexpression significantly increased the expression of
. The HSV of the Boer goat contributed to superior skeletal muscle growth via the dose effects of overlapping genes.</abstract><cop>China</cop><pub>Kunming Institute of Zoology, The Chinese Academy of Sciences</pub><pmid>36785897</pmid><doi>10.24272/j.issn.2095-8137.2022.384</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2095-8137 |
| ispartof | Dōngwùxué yánjiū, 2023-03, Vol.44 (2), p.303-314 |
| issn | 2095-8137 0254-5853 |
| language | eng |
| recordid | cdi_proquest_journals_2814984284 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animal husbandry Animals Annealing Cell differentiation Cell proliferation Cells (biology) Chromosome 17 Chromosomes Chromosomes, Human, Pair 17 Copy number DNA Copy Number Variations Gene duplication Gene sequencing Genes Genetic testing Genetics Genome Genomes Genotypes Goats Goats - genetics Heredity Humans Muscle Development Muscles Musculoskeletal system Proliferation Reproduction (copying) RNA sequencing Satellite cells Signal analysis Skeletal muscle Transcription |
| title | A 1.1 Mb duplication CNV on chromosome 17 contributes to skeletal muscle development in Boer goats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T20%3A51%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%201.1%20Mb%20duplication%20CNV%20on%20chromosome%2017%20contributes%20to%20skeletal%20muscle%20development%20in%20Boer%20goats&rft.jtitle=D%C5%8Dngw%C3%B9xu%C3%A9%20y%C3%A1nji%C5%AB&rft.au=Yuan,%20Ying&rft.aucorp=Institute%20of%20Animal%20Science,%20Chinese%20Academy%20of%20Agricultural%20Sciences%20(CAAS),%20Beijing%20100193,%20China&rft.date=2023-03-18&rft.volume=44&rft.issue=2&rft.spage=303&rft.epage=314&rft.pages=303-314&rft.issn=2095-8137&rft_id=info:doi/10.24272/j.issn.2095-8137.2022.384&rft_dat=%3Cproquest_pubme%3E2814984284%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2814984284&rft_id=info:pmid/36785897&rfr_iscdi=true |