Antimutagenic 1,4-Dihydropyridine AV-153 Normalizes Expression of GLUT1, GLUT4, INOS, PARP1, and Gamma H2AX Histone in Myocardium of Rats with Streptozotocin Model of Diabetes Mellitus

Diabetic cardiomyopathy increases the risk of heart failure and worsens prognosis for diabetes mellitus (DM) patients. Its development depends on many factors, including modification of nitric oxide production and impaired DNA repair. The goal of the present work was to study effects of a 1,4-dihydr...

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Veröffentlicht in:	Proceedings of the Latvian Academy of Sciences. Section B, Natural Sciences Natural Sciences, 2023-04, Vol.77 (2), p.96-101
Hauptverfasser:	Rostoka, Evita, Isajevs, Sergejs, Sokolovska, Jeļizaveta, Duburs, Gunārs, Sjakste, Nikolajs
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiomyopathy Congestive heart failure Deoxyribonucleic acid Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) diabetic cardiomyopathy Dihydropyridine DNA DNA damage DNA repair Gene expression Glucose Glucose metabolism Glucose transport glucose transporters Histone H2A Histones Immunohistochemistry In vivo methods and tests Insulin Myocardium Nitric oxide Nitric-oxide synthase Poly(ADP-ribose) polymerase Protein expression Protein transport Proteins Streptozocin
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