Hollow carbon nanospheres loaded with upconversion nanoparticles for chemo-photothermal synergistic cancer therapy
Nanomaterials possess multidisciplinary capabilities in cancer diagnosis and treatment, including imaging and therapeutic, and thus have wide range of applications in the field of nanomedicine. To exploit these capabilities, herein we report a novel nanoplatform of upconversion nanoparticle (UCNPs)-...
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| Veröffentlicht in: | Journal of materials science 2023-05, Vol.58 (19), p.8034-8046 |
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| creator | Jiao, Xiaorui Zhou, Wei Akhtar, Mahmood Hassan He, Di Demi Zhou, Weiping Yao, Lang Zhang, Yun Liu, Ning Yu, Cong |
| description | Nanomaterials possess multidisciplinary capabilities in cancer diagnosis and treatment, including imaging and therapeutic, and thus have wide range of applications in the field of nanomedicine. To exploit these capabilities, herein we report a novel nanoplatform of upconversion nanoparticle (UCNPs)-decorated hollow mesoporous carbon nanoparticles (HMCNs@UCNPs) prepared by a facile hydrothermal approach. Morphological and structural analyses of the newly synthesized nanomaterial were performed using high-resolution TEM (HR-TEM), XRD, and BET techniques. The porous nature of the HMCNs@UCNPs nanomaterial further assisted to load anticancer drug (DOX, doxorubicin) effectively. Hence, the DOX-modified nanoplatform HMCNs@UCNPs-DOX worked as a multimodal theranostic probe, concurrently demonstrating chemotherapeutic as well as photothermal effects subjected to NIR-stimulation. Additionally, synergistic effects of the developed nanoplatform were confirmed by in vitro and in vivo studies using MCF-7 cell line and mouse models, respectively.
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| doi_str_mv | 10.1007/s10853-023-08508-1 |
| format | Article |
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Graphical Abstract</description><subject>Antimitotic agents</subject><subject>Antineoplastic agents</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Carbon</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry and Materials Science</subject><subject>Chemotherapy</subject><subject>Classical Mechanics</subject><subject>Crystallography and Scattering Methods</subject><subject>Doxorubicin</subject><subject>Health aspects</subject><subject>In vivo methods and tests</subject><subject>Laboratories</subject><subject>Life sciences</subject><subject>Materials for Life Sciences</subject><subject>Materials Science</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Nanospheres</subject><subject>Polymer Sciences</subject><subject>Solid Mechanics</subject><subject>Synergistic effect</subject><subject>Upconversion</subject><issn>0022-2461</issn><issn>1573-4803</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kc1qGzEURkVIIU7aF8hqIKsuJtW_5GUIaW0IFJp0LWTNHVthRppKclK_feQ4EAylXMQF6ZwrpA-hS4KvCcbqWyZYC9ZiWpcWWLfkBM2IUKzlGrNTNMOY0pZySc7Qec5PGGOhKJmhtIjDEF8aZ9MqhibYEPO0gQS5GaLtoGtefNk028nF8Awp-3dosql4N1Ssj6lxGxhjO21iiaXKox2avAuQ1j5Xqg4PDlKzP7LT7jP61Nshw5f3foF-f797vF209z9_LG9v7lvHKS6tkopJ2a1oZ5VjloPrhZhjqpgVZEXAUY2tldpx0nfSScmZ6qjWnMyVUH3HLtDVYe6U4p8t5GKe4jaFeqWhmnAiBNfzD2ptBzA-9LEk60afnblRfC40l2pPXf-DqtXB6OvXQO_r_pHw9UioTIG_ZW23OZvlw69jlh5Yl2LOCXozJT_atDMEm3285hCvqfGat3gNqRI7SLnCYQ3p43X_sV4BhXCoOw</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Jiao, Xiaorui</creator><creator>Zhou, Wei</creator><creator>Akhtar, Mahmood Hassan</creator><creator>He, Di Demi</creator><creator>Zhou, Weiping</creator><creator>Yao, Lang</creator><creator>Zhang, Yun</creator><creator>Liu, Ning</creator><creator>Yu, Cong</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>L6V</scope><scope>M7S</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><orcidid>https://orcid.org/0000-0002-8904-0644</orcidid></search><sort><creationdate>20230501</creationdate><title>Hollow carbon nanospheres loaded with upconversion nanoparticles for chemo-photothermal synergistic cancer therapy</title><author>Jiao, Xiaorui ; Zhou, Wei ; Akhtar, Mahmood Hassan ; He, Di Demi ; Zhou, Weiping ; Yao, Lang ; Zhang, Yun ; Liu, Ning ; Yu, Cong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-767366db2da7c3a4ecf5590273a51b1ec280aa68c41fd6c66437d288419757fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antimitotic agents</topic><topic>Antineoplastic agents</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Carbon</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry and Materials Science</topic><topic>Chemotherapy</topic><topic>Classical Mechanics</topic><topic>Crystallography and Scattering Methods</topic><topic>Doxorubicin</topic><topic>Health aspects</topic><topic>In vivo methods and tests</topic><topic>Laboratories</topic><topic>Life sciences</topic><topic>Materials for Life Sciences</topic><topic>Materials Science</topic><topic>Nanomaterials</topic><topic>Nanoparticles</topic><topic>Nanospheres</topic><topic>Polymer Sciences</topic><topic>Solid Mechanics</topic><topic>Synergistic effect</topic><topic>Upconversion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiao, Xiaorui</creatorcontrib><creatorcontrib>Zhou, Wei</creatorcontrib><creatorcontrib>Akhtar, Mahmood Hassan</creatorcontrib><creatorcontrib>He, Di Demi</creatorcontrib><creatorcontrib>Zhou, Weiping</creatorcontrib><creatorcontrib>Yao, Lang</creatorcontrib><creatorcontrib>Zhang, Yun</creatorcontrib><creatorcontrib>Liu, Ning</creatorcontrib><creatorcontrib>Yu, Cong</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>ProQuest Engineering Collection</collection><collection>Engineering Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><jtitle>Journal of materials science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiao, Xiaorui</au><au>Zhou, Wei</au><au>Akhtar, Mahmood Hassan</au><au>He, Di Demi</au><au>Zhou, Weiping</au><au>Yao, Lang</au><au>Zhang, Yun</au><au>Liu, Ning</au><au>Yu, Cong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hollow carbon nanospheres loaded with upconversion nanoparticles for chemo-photothermal synergistic cancer therapy</atitle><jtitle>Journal of materials science</jtitle><stitle>J Mater Sci</stitle><date>2023-05-01</date><risdate>2023</risdate><volume>58</volume><issue>19</issue><spage>8034</spage><epage>8046</epage><pages>8034-8046</pages><issn>0022-2461</issn><eissn>1573-4803</eissn><abstract>Nanomaterials possess multidisciplinary capabilities in cancer diagnosis and treatment, including imaging and therapeutic, and thus have wide range of applications in the field of nanomedicine. To exploit these capabilities, herein we report a novel nanoplatform of upconversion nanoparticle (UCNPs)-decorated hollow mesoporous carbon nanoparticles (HMCNs@UCNPs) prepared by a facile hydrothermal approach. Morphological and structural analyses of the newly synthesized nanomaterial were performed using high-resolution TEM (HR-TEM), XRD, and BET techniques. The porous nature of the HMCNs@UCNPs nanomaterial further assisted to load anticancer drug (DOX, doxorubicin) effectively. Hence, the DOX-modified nanoplatform HMCNs@UCNPs-DOX worked as a multimodal theranostic probe, concurrently demonstrating chemotherapeutic as well as photothermal effects subjected to NIR-stimulation. Additionally, synergistic effects of the developed nanoplatform were confirmed by in vitro and in vivo studies using MCF-7 cell line and mouse models, respectively.
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| subjects | Antimitotic agents Antineoplastic agents Cancer Cancer therapies Carbon Characterization and Evaluation of Materials Chemistry and Materials Science Chemotherapy Classical Mechanics Crystallography and Scattering Methods Doxorubicin Health aspects In vivo methods and tests Laboratories Life sciences Materials for Life Sciences Materials Science Nanomaterials Nanoparticles Nanospheres Polymer Sciences Solid Mechanics Synergistic effect Upconversion |
| title | Hollow carbon nanospheres loaded with upconversion nanoparticles for chemo-photothermal synergistic cancer therapy |
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