Advancements in the Preparation of 4H‐Chromenes: An Overview

Functionalized 4H‐chromenes represent one class of the most important structural scaffolds in both synthetic and medicinal chemistry. They often appear in an arrange of biological natural products, pharmaceutical agents and drug candidates. The significance has stimulated the development of efficien...

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Veröffentlicht in:	Advanced synthesis & catalysis 2023-05, Vol.365 (9), p.1290-1331
Hauptverfasser:	Wen, Zhong, Yang, Kai‐Cheng, Deng, Jun‐Feng, Chen, Long
Format:	Artikel
Sprache:	eng
Schlagworte:	1-benzopyrylium ion 2-iminochromenes 2H-chromenes 4H-chromenes Chemical reactions Cycloaddition Natural products o-QMs
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description	Functionalized 4H‐chromenes represent one class of the most important structural scaffolds in both synthetic and medicinal chemistry. They often appear in an arrange of biological natural products, pharmaceutical agents and drug candidates. The significance has stimulated the development of efficient methodologies for the synthesis of such compounds. In this review, a comprehensive discussion on different synthetic approaches to 4H‐chromenes has been presented with an emphasis on reaction features and mechanisms. Three main categories are outlined: 1) nucleophilic addition to 2H‐chromene derivatives, 2) 4H‐chromene ring formation involved cycloaddition or cyclization reactions, and 3) miscellaneous reactions.
doi_str_mv	10.1002/adsc.202201409
format	Article
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subjects	1-benzopyrylium ion 2-iminochromenes 2H-chromenes 4H-chromenes Chemical reactions Cycloaddition Natural products o-QMs
title	Advancements in the Preparation of 4H‐Chromenes: An Overview
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