Accuracy of 18F-FDG PET/CT in monitoring therapeutic response and detection of loco-regional recurrence and metastatic deposits of colorectal cancer in comparison to CT
Background The study shows the role of PET/CT in monitoring response to therapy in colorectal cancer as well as detection of loco-regional recurrence and metastatic deposits hence guiding the clinician to the proper management strategy. Sixty patients (41male and 19 female) were included in our stud...
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| Veröffentlicht in: | Egyptian Journal of Radiology and Nuclear Medicine 2020-03, Vol.51 (1), p.37-8, Article 37 |
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| container_title | Egyptian Journal of Radiology and Nuclear Medicine |
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| creator | Hetta, Waleed Niazi, Gamal Abdelbary, Mohammed H. |
| description | Background
The study shows the role of PET/CT in monitoring response to therapy in colorectal cancer as well as detection of loco-regional recurrence and metastatic deposits hence guiding the clinician to the proper management strategy. Sixty patients (41male and 19 female) were included in our study. All patients are pathologically proven colorectal cancer. They had undergone 18F-FDG PET/CT for follow up post-therapeutic (operative, and/or chemotherapy and/or radiotherapy) follow up for metastatic or recurrent colorectal cancer during the period from September 2015 to August 2017.
Results
Our study demonstrated that FDG PET/CT is highly sensitive and specific in assessing local recurrence and distant metastasis in patient with pathologically proved colorectal cancer, with sensitivity 95.45%, specificity 97.3%, and accuracy 96.7% in detection of local recurrence; and sensitivity, specificity, and accuracy of 100% in detection of hepatic metastasis as well as in detection of nodal metastasis.
Conclusion
FDG PET/CT is an accurate modality in the treatment plan of cancer colon in monitoring therapeutic response as well as defining their local extent and distant metastatic disease thus provides valuable information that is very helpful in the clinical decision-making process. |
| doi_str_mv | 10.1186/s43055-020-00151-z |
| format | Article |
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The study shows the role of PET/CT in monitoring response to therapy in colorectal cancer as well as detection of loco-regional recurrence and metastatic deposits hence guiding the clinician to the proper management strategy. Sixty patients (41male and 19 female) were included in our study. All patients are pathologically proven colorectal cancer. They had undergone 18F-FDG PET/CT for follow up post-therapeutic (operative, and/or chemotherapy and/or radiotherapy) follow up for metastatic or recurrent colorectal cancer during the period from September 2015 to August 2017.
Results
Our study demonstrated that FDG PET/CT is highly sensitive and specific in assessing local recurrence and distant metastasis in patient with pathologically proved colorectal cancer, with sensitivity 95.45%, specificity 97.3%, and accuracy 96.7% in detection of local recurrence; and sensitivity, specificity, and accuracy of 100% in detection of hepatic metastasis as well as in detection of nodal metastasis.
Conclusion
FDG PET/CT is an accurate modality in the treatment plan of cancer colon in monitoring therapeutic response as well as defining their local extent and distant metastatic disease thus provides valuable information that is very helpful in the clinical decision-making process.</description><identifier>ISSN: 2090-4762</identifier><identifier>ISSN: 0378-603X</identifier><identifier>EISSN: 2090-4762</identifier><identifier>DOI: 10.1186/s43055-020-00151-z</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Abdomen ; Accuracy ; Biopsy ; Cancer ; Cancer therapies ; Chemotherapy ; Colorectal cancer ; CRC ; Diabetes ; FDG PET/CT ; Health aspects ; Imaging ; Lymphatic system ; Medical imaging ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Metastasis ; Monitoring response ; Nuclear Medicine ; Patients ; PET imaging ; Radiation therapy ; Radiology ; Strategic planning (Business) ; Tomography</subject><ispartof>Egyptian Journal of Radiology and Nuclear Medicine, 2020-03, Vol.51 (1), p.37-8, Article 37</ispartof><rights>The Author(s) 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-c7f4255cb72cd18aa4bc79d0e983d4ce7a3be7f40ae28dbf5bb6ea4f97672b523</citedby><cites>FETCH-LOGICAL-c496t-c7f4255cb72cd18aa4bc79d0e983d4ce7a3be7f40ae28dbf5bb6ea4f97672b523</cites><orcidid>0000-0002-2453-7449</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids></links><search><creatorcontrib>Hetta, Waleed</creatorcontrib><creatorcontrib>Niazi, Gamal</creatorcontrib><creatorcontrib>Abdelbary, Mohammed H.</creatorcontrib><title>Accuracy of 18F-FDG PET/CT in monitoring therapeutic response and detection of loco-regional recurrence and metastatic deposits of colorectal cancer in comparison to CT</title><title>Egyptian Journal of Radiology and Nuclear Medicine</title><addtitle>Egypt J Radiol Nucl Med</addtitle><description>Background
The study shows the role of PET/CT in monitoring response to therapy in colorectal cancer as well as detection of loco-regional recurrence and metastatic deposits hence guiding the clinician to the proper management strategy. Sixty patients (41male and 19 female) were included in our study. All patients are pathologically proven colorectal cancer. They had undergone 18F-FDG PET/CT for follow up post-therapeutic (operative, and/or chemotherapy and/or radiotherapy) follow up for metastatic or recurrent colorectal cancer during the period from September 2015 to August 2017.
Results
Our study demonstrated that FDG PET/CT is highly sensitive and specific in assessing local recurrence and distant metastasis in patient with pathologically proved colorectal cancer, with sensitivity 95.45%, specificity 97.3%, and accuracy 96.7% in detection of local recurrence; and sensitivity, specificity, and accuracy of 100% in detection of hepatic metastasis as well as in detection of nodal metastasis.
Conclusion
FDG PET/CT is an accurate modality in the treatment plan of cancer colon in monitoring therapeutic response as well as defining their local extent and distant metastatic disease thus provides valuable information that is very helpful in the clinical decision-making process.</description><subject>Abdomen</subject><subject>Accuracy</subject><subject>Biopsy</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Colorectal cancer</subject><subject>CRC</subject><subject>Diabetes</subject><subject>FDG PET/CT</subject><subject>Health aspects</subject><subject>Imaging</subject><subject>Lymphatic system</subject><subject>Medical imaging</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Metastasis</subject><subject>Monitoring response</subject><subject>Nuclear Medicine</subject><subject>Patients</subject><subject>PET imaging</subject><subject>Radiation therapy</subject><subject>Radiology</subject><subject>Strategic planning (Business)</subject><subject>Tomography</subject><issn>2090-4762</issn><issn>0378-603X</issn><issn>2090-4762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNp9kstu1DAUhiMEElXpC7CyxDqt7cSXLEdDp1SqBIthbTn2yeDRJA62Z9E-EY_JSYMoSIh4Edv6_s-3U1XvGb1mTMub3DZUiJpyWlPKBKufXlUXnHa0bpXkr__ov62ucj5S_FokZXtR_dg4d07WPZI4EKZ39e7jHflyu7_Z7kmYyBinUGIK04GUb5DsDOcSHEmQ5zhlIHbyxEMBV0KcFsUpulgnOODQnpBDeYLJreQIxeZiF4OHOeZQ8pJx8RSRLBhwFtm0rOziONsUMmpLJNv9u-rNYE8Zrn79L6uvu9v99lP98Pnufrt5qF3byVI7NbRcCNcr7jzT1ra9U52n0OnGtw6UbXpAhlrg2veD6HsJth06JRXvBW8uq_vV66M9mjmF0aZHE20wzxMxHYxNeIITGAEDFcC0F7pDodActOq71qtB2B48uj6srjnF72fIxRzjOeHFZMM141JTLcULdbAoDdMQCz7IGLIzG0SY6qiUSF3_g8LmYQwuTjAEnP8rwNeASzHnBMPvwzBqlroxa90YrBvzXDfmCUPNGsrz8uiQXnb8n9RP7rHHLg</recordid><startdate>20200305</startdate><enddate>20200305</enddate><creator>Hetta, Waleed</creator><creator>Niazi, Gamal</creator><creator>Abdelbary, Mohammed H.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-2453-7449</orcidid></search><sort><creationdate>20200305</creationdate><title>Accuracy of 18F-FDG PET/CT in monitoring therapeutic response and detection of loco-regional recurrence and metastatic deposits of colorectal cancer in comparison to CT</title><author>Hetta, Waleed ; Niazi, Gamal ; Abdelbary, Mohammed H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-c7f4255cb72cd18aa4bc79d0e983d4ce7a3be7f40ae28dbf5bb6ea4f97672b523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abdomen</topic><topic>Accuracy</topic><topic>Biopsy</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Colorectal cancer</topic><topic>CRC</topic><topic>Diabetes</topic><topic>FDG PET/CT</topic><topic>Health aspects</topic><topic>Imaging</topic><topic>Lymphatic system</topic><topic>Medical imaging</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Metastasis</topic><topic>Monitoring response</topic><topic>Nuclear Medicine</topic><topic>Patients</topic><topic>PET imaging</topic><topic>Radiation therapy</topic><topic>Radiology</topic><topic>Strategic planning (Business)</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hetta, Waleed</creatorcontrib><creatorcontrib>Niazi, Gamal</creatorcontrib><creatorcontrib>Abdelbary, Mohammed H.</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Egyptian Journal of Radiology and Nuclear Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hetta, Waleed</au><au>Niazi, Gamal</au><au>Abdelbary, Mohammed H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Accuracy of 18F-FDG PET/CT in monitoring therapeutic response and detection of loco-regional recurrence and metastatic deposits of colorectal cancer in comparison to CT</atitle><jtitle>Egyptian Journal of Radiology and Nuclear Medicine</jtitle><stitle>Egypt J Radiol Nucl Med</stitle><date>2020-03-05</date><risdate>2020</risdate><volume>51</volume><issue>1</issue><spage>37</spage><epage>8</epage><pages>37-8</pages><artnum>37</artnum><issn>2090-4762</issn><issn>0378-603X</issn><eissn>2090-4762</eissn><abstract>Background
The study shows the role of PET/CT in monitoring response to therapy in colorectal cancer as well as detection of loco-regional recurrence and metastatic deposits hence guiding the clinician to the proper management strategy. Sixty patients (41male and 19 female) were included in our study. All patients are pathologically proven colorectal cancer. They had undergone 18F-FDG PET/CT for follow up post-therapeutic (operative, and/or chemotherapy and/or radiotherapy) follow up for metastatic or recurrent colorectal cancer during the period from September 2015 to August 2017.
Results
Our study demonstrated that FDG PET/CT is highly sensitive and specific in assessing local recurrence and distant metastasis in patient with pathologically proved colorectal cancer, with sensitivity 95.45%, specificity 97.3%, and accuracy 96.7% in detection of local recurrence; and sensitivity, specificity, and accuracy of 100% in detection of hepatic metastasis as well as in detection of nodal metastasis.
Conclusion
FDG PET/CT is an accurate modality in the treatment plan of cancer colon in monitoring therapeutic response as well as defining their local extent and distant metastatic disease thus provides valuable information that is very helpful in the clinical decision-making process.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s43055-020-00151-z</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-2453-7449</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature OA/Free Journals |
| subjects | Abdomen Accuracy Biopsy Cancer Cancer therapies Chemotherapy Colorectal cancer CRC Diabetes FDG PET/CT Health aspects Imaging Lymphatic system Medical imaging Medical research Medicine Medicine & Public Health Medicine, Experimental Metastasis Monitoring response Nuclear Medicine Patients PET imaging Radiation therapy Radiology Strategic planning (Business) Tomography |
| title | Accuracy of 18F-FDG PET/CT in monitoring therapeutic response and detection of loco-regional recurrence and metastatic deposits of colorectal cancer in comparison to CT |
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