Diffusion tensor imaging for assessment of normally appearing white matter of the brain and spinal cord in cases of multiple sclerosis: a multi-parametric correlation in view of patient’s clinical status
Background Conventional MRI provides important morphologic information regarding the brain and spinal cord involvement by demyelinating plaques. However, it is of almost no value in assessing the normal-appearing white matter which has been proved by multiple pathologic studies to be directly and in...
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| Veröffentlicht in: | Egyptian Journal of Radiology and Nuclear Medicine 2019-09, Vol.50 (1), p.30-10, Article 30 |
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| description | Background
Conventional MRI provides important morphologic information regarding the brain and spinal cord involvement by demyelinating plaques. However, it is of almost no value in assessing the normal-appearing white matter which has been proved by multiple pathologic studies to be directly and indirectly involved in the process of multiple sclerosis. Diffusion-weighted imaging and diffusion tensor imaging MRI have been widely used in multiple researches as a better solution for studying the normal-appearing white matter. The purpose of this study was to evaluate the role of diffusion tensor imaging examination of the normal-appearing white matter of the brain and spinal cord in patients with multiple sclerosis and to determine the relationship between diffusion tensor imaging metrics and patient’s clinical status.
Results
The significant negative correlation found between expanded disability status scale score of secondary progressive MS patients and global (brain and spinal cord) average fractional anisotropy values in normal-appearing white matter and tracts (
P
= 0.000). Correlation between average apparent diffusion coefficient of corpus callosum tract and expanded disability status scale score revealed a significant positive correlation in RRMS (
P
= 0.001). While in secondary progressive MS, a significant negative correlation between fractional anisotropy average of the corpus callosum tract and expanded disability status scale score was noted (
P
= 0.015).
Conclusion
There is a strong relationship between diffusion tensor imaging readings and clinical status of patients can be used to understand unexplained deterioration over disease course and also can be used when conventional MRI findings are equivocal. Corpus callosum affection in MS patients is intimately related to clinical status and its assessment should be done whenever possible. |
| doi_str_mv | 10.1186/s43055-019-0031-x |
| format | Article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_proquest_journals_2812337871</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A680162847</galeid><doaj_id>oai_doaj_org_article_0335aa3af019455ea82839c0ea78413f</doaj_id><sourcerecordid>A680162847</sourcerecordid><originalsourceid>FETCH-LOGICAL-c492t-e0b0c2d5f6d095a934e79b0abe93be6d3a7268cf0f498d1b980c72f542628c9f3</originalsourceid><addsrcrecordid>eNp1Uktu1TAUjRBIVKULYGaJcYp_SRxmVfm0UiUmMLZunOtXPyV2sP1oO-s2WBSbYCV1CKIggT3w1dE5x_dXVS8ZPWVMta-TFLRpasr6mlLB6tsn1RGnPa1l1_Knf8TPq5OU9rQcSSlr5VH1_a2z9pBc8CSjTyESN8PO-R2xJYaUMKUZfSbBEh_iDNN0R2BZEOJKurl2GckMOWNcKfkayRDBeQJ-JGlxHiZiQhxJgQwUt5U1H6bslglJMhPGkFx6Q2BD6wUizJijM6su4gR5Ta7Ivzq8WdVLQUpGP-6_JWIm550pf6QM-ZBeVM8sTAlPfr3H1ef37z6dX9RXHz9cnp9d1Ub2PNdIB2r42Nh2pH0DvZDY9QOFAXsxYDsK6HirjKVW9mpkQ6-o6bhtJG-5Mr0Vx9Xl5jsG2Osllp7FOx3A6Z9AiDsNMbtSnaZCNAACbJmObBoExZXoDUXolGRi9Xq1eS0xfDlgynofDrH0LWmuGBeiUx17ZO2gmDpvQ45gZpeMPmtVmSVXsius03-wyh1xdiZ4tK7gfwnYJjBlDCmi_V0Mo3rdLb3tli7Z63W39G3R8E2TlnUHMD4m_H_RA2l11eM</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2812337871</pqid></control><display><type>article</type><title>Diffusion tensor imaging for assessment of normally appearing white matter of the brain and spinal cord in cases of multiple sclerosis: a multi-parametric correlation in view of patient’s clinical status</title><source>Springer Nature - Complete Springer Journals</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>ElSayed, Mohamed ElSayed Kamel Abdulaziz ; El-Toukhy, Mohamed Mohamed Badawy ; Asaad, Ramy Edward ; El-Serafy, Omar Amin</creator><creatorcontrib>ElSayed, Mohamed ElSayed Kamel Abdulaziz ; El-Toukhy, Mohamed Mohamed Badawy ; Asaad, Ramy Edward ; El-Serafy, Omar Amin</creatorcontrib><description>Background
Conventional MRI provides important morphologic information regarding the brain and spinal cord involvement by demyelinating plaques. However, it is of almost no value in assessing the normal-appearing white matter which has been proved by multiple pathologic studies to be directly and indirectly involved in the process of multiple sclerosis. Diffusion-weighted imaging and diffusion tensor imaging MRI have been widely used in multiple researches as a better solution for studying the normal-appearing white matter. The purpose of this study was to evaluate the role of diffusion tensor imaging examination of the normal-appearing white matter of the brain and spinal cord in patients with multiple sclerosis and to determine the relationship between diffusion tensor imaging metrics and patient’s clinical status.
Results
The significant negative correlation found between expanded disability status scale score of secondary progressive MS patients and global (brain and spinal cord) average fractional anisotropy values in normal-appearing white matter and tracts (
P
= 0.000). Correlation between average apparent diffusion coefficient of corpus callosum tract and expanded disability status scale score revealed a significant positive correlation in RRMS (
P
= 0.001). While in secondary progressive MS, a significant negative correlation between fractional anisotropy average of the corpus callosum tract and expanded disability status scale score was noted (
P
= 0.015).
Conclusion
There is a strong relationship between diffusion tensor imaging readings and clinical status of patients can be used to understand unexplained deterioration over disease course and also can be used when conventional MRI findings are equivocal. Corpus callosum affection in MS patients is intimately related to clinical status and its assessment should be done whenever possible.</description><identifier>ISSN: 2090-4762</identifier><identifier>ISSN: 0378-603X</identifier><identifier>EISSN: 2090-4762</identifier><identifier>DOI: 10.1186/s43055-019-0031-x</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Anisotropy ; Apparent diffusion coefficient ; Diagnostic imaging ; Diffusion tensor magnetic resonance imaging ; Disease ; Fractional anisotropy ; Imaging ; Laboratories ; Magnetic resonance imaging ; Medicine ; Medicine & Public Health ; Multiple sclerosis ; Nervous system ; Normally appearing white matter ; Nuclear Medicine ; Patients ; Radiology ; Spinal cord ; Tractography</subject><ispartof>Egyptian Journal of Radiology and Nuclear Medicine, 2019-09, Vol.50 (1), p.30-10, Article 30</ispartof><rights>The Author(s) 2019</rights><rights>COPYRIGHT 2019 Springer</rights><rights>The Author(s) 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-e0b0c2d5f6d095a934e79b0abe93be6d3a7268cf0f498d1b980c72f542628c9f3</citedby><cites>FETCH-LOGICAL-c492t-e0b0c2d5f6d095a934e79b0abe93be6d3a7268cf0f498d1b980c72f542628c9f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids></links><search><creatorcontrib>ElSayed, Mohamed ElSayed Kamel Abdulaziz</creatorcontrib><creatorcontrib>El-Toukhy, Mohamed Mohamed Badawy</creatorcontrib><creatorcontrib>Asaad, Ramy Edward</creatorcontrib><creatorcontrib>El-Serafy, Omar Amin</creatorcontrib><title>Diffusion tensor imaging for assessment of normally appearing white matter of the brain and spinal cord in cases of multiple sclerosis: a multi-parametric correlation in view of patient’s clinical status</title><title>Egyptian Journal of Radiology and Nuclear Medicine</title><addtitle>Egypt J Radiol Nucl Med</addtitle><description>Background
Conventional MRI provides important morphologic information regarding the brain and spinal cord involvement by demyelinating plaques. However, it is of almost no value in assessing the normal-appearing white matter which has been proved by multiple pathologic studies to be directly and indirectly involved in the process of multiple sclerosis. Diffusion-weighted imaging and diffusion tensor imaging MRI have been widely used in multiple researches as a better solution for studying the normal-appearing white matter. The purpose of this study was to evaluate the role of diffusion tensor imaging examination of the normal-appearing white matter of the brain and spinal cord in patients with multiple sclerosis and to determine the relationship between diffusion tensor imaging metrics and patient’s clinical status.
Results
The significant negative correlation found between expanded disability status scale score of secondary progressive MS patients and global (brain and spinal cord) average fractional anisotropy values in normal-appearing white matter and tracts (
P
= 0.000). Correlation between average apparent diffusion coefficient of corpus callosum tract and expanded disability status scale score revealed a significant positive correlation in RRMS (
P
= 0.001). While in secondary progressive MS, a significant negative correlation between fractional anisotropy average of the corpus callosum tract and expanded disability status scale score was noted (
P
= 0.015).
Conclusion
There is a strong relationship between diffusion tensor imaging readings and clinical status of patients can be used to understand unexplained deterioration over disease course and also can be used when conventional MRI findings are equivocal. Corpus callosum affection in MS patients is intimately related to clinical status and its assessment should be done whenever possible.</description><subject>Anisotropy</subject><subject>Apparent diffusion coefficient</subject><subject>Diagnostic imaging</subject><subject>Diffusion tensor magnetic resonance imaging</subject><subject>Disease</subject><subject>Fractional anisotropy</subject><subject>Imaging</subject><subject>Laboratories</subject><subject>Magnetic resonance imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multiple sclerosis</subject><subject>Nervous system</subject><subject>Normally appearing white matter</subject><subject>Nuclear Medicine</subject><subject>Patients</subject><subject>Radiology</subject><subject>Spinal cord</subject><subject>Tractography</subject><issn>2090-4762</issn><issn>0378-603X</issn><issn>2090-4762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNp1Uktu1TAUjRBIVKULYGaJcYp_SRxmVfm0UiUmMLZunOtXPyV2sP1oO-s2WBSbYCV1CKIggT3w1dE5x_dXVS8ZPWVMta-TFLRpasr6mlLB6tsn1RGnPa1l1_Knf8TPq5OU9rQcSSlr5VH1_a2z9pBc8CSjTyESN8PO-R2xJYaUMKUZfSbBEh_iDNN0R2BZEOJKurl2GckMOWNcKfkayRDBeQJ-JGlxHiZiQhxJgQwUt5U1H6bslglJMhPGkFx6Q2BD6wUizJijM6su4gR5Ta7Ivzq8WdVLQUpGP-6_JWIm550pf6QM-ZBeVM8sTAlPfr3H1ef37z6dX9RXHz9cnp9d1Ub2PNdIB2r42Nh2pH0DvZDY9QOFAXsxYDsK6HirjKVW9mpkQ6-o6bhtJG-5Mr0Vx9Xl5jsG2Osllp7FOx3A6Z9AiDsNMbtSnaZCNAACbJmObBoExZXoDUXolGRi9Xq1eS0xfDlgynofDrH0LWmuGBeiUx17ZO2gmDpvQ45gZpeMPmtVmSVXsius03-wyh1xdiZ4tK7gfwnYJjBlDCmi_V0Mo3rdLb3tli7Z63W39G3R8E2TlnUHMD4m_H_RA2l11eM</recordid><startdate>20190906</startdate><enddate>20190906</enddate><creator>ElSayed, Mohamed ElSayed Kamel Abdulaziz</creator><creator>El-Toukhy, Mohamed Mohamed Badawy</creator><creator>Asaad, Ramy Edward</creator><creator>El-Serafy, Omar Amin</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>DOA</scope></search><sort><creationdate>20190906</creationdate><title>Diffusion tensor imaging for assessment of normally appearing white matter of the brain and spinal cord in cases of multiple sclerosis: a multi-parametric correlation in view of patient’s clinical status</title><author>ElSayed, Mohamed ElSayed Kamel Abdulaziz ; El-Toukhy, Mohamed Mohamed Badawy ; Asaad, Ramy Edward ; El-Serafy, Omar Amin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-e0b0c2d5f6d095a934e79b0abe93be6d3a7268cf0f498d1b980c72f542628c9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anisotropy</topic><topic>Apparent diffusion coefficient</topic><topic>Diagnostic imaging</topic><topic>Diffusion tensor magnetic resonance imaging</topic><topic>Disease</topic><topic>Fractional anisotropy</topic><topic>Imaging</topic><topic>Laboratories</topic><topic>Magnetic resonance imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multiple sclerosis</topic><topic>Nervous system</topic><topic>Normally appearing white matter</topic><topic>Nuclear Medicine</topic><topic>Patients</topic><topic>Radiology</topic><topic>Spinal cord</topic><topic>Tractography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ElSayed, Mohamed ElSayed Kamel Abdulaziz</creatorcontrib><creatorcontrib>El-Toukhy, Mohamed Mohamed Badawy</creatorcontrib><creatorcontrib>Asaad, Ramy Edward</creatorcontrib><creatorcontrib>El-Serafy, Omar Amin</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Egyptian Journal of Radiology and Nuclear Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ElSayed, Mohamed ElSayed Kamel Abdulaziz</au><au>El-Toukhy, Mohamed Mohamed Badawy</au><au>Asaad, Ramy Edward</au><au>El-Serafy, Omar Amin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diffusion tensor imaging for assessment of normally appearing white matter of the brain and spinal cord in cases of multiple sclerosis: a multi-parametric correlation in view of patient’s clinical status</atitle><jtitle>Egyptian Journal of Radiology and Nuclear Medicine</jtitle><stitle>Egypt J Radiol Nucl Med</stitle><date>2019-09-06</date><risdate>2019</risdate><volume>50</volume><issue>1</issue><spage>30</spage><epage>10</epage><pages>30-10</pages><artnum>30</artnum><issn>2090-4762</issn><issn>0378-603X</issn><eissn>2090-4762</eissn><abstract>Background
Conventional MRI provides important morphologic information regarding the brain and spinal cord involvement by demyelinating plaques. However, it is of almost no value in assessing the normal-appearing white matter which has been proved by multiple pathologic studies to be directly and indirectly involved in the process of multiple sclerosis. Diffusion-weighted imaging and diffusion tensor imaging MRI have been widely used in multiple researches as a better solution for studying the normal-appearing white matter. The purpose of this study was to evaluate the role of diffusion tensor imaging examination of the normal-appearing white matter of the brain and spinal cord in patients with multiple sclerosis and to determine the relationship between diffusion tensor imaging metrics and patient’s clinical status.
Results
The significant negative correlation found between expanded disability status scale score of secondary progressive MS patients and global (brain and spinal cord) average fractional anisotropy values in normal-appearing white matter and tracts (
P
= 0.000). Correlation between average apparent diffusion coefficient of corpus callosum tract and expanded disability status scale score revealed a significant positive correlation in RRMS (
P
= 0.001). While in secondary progressive MS, a significant negative correlation between fractional anisotropy average of the corpus callosum tract and expanded disability status scale score was noted (
P
= 0.015).
Conclusion
There is a strong relationship between diffusion tensor imaging readings and clinical status of patients can be used to understand unexplained deterioration over disease course and also can be used when conventional MRI findings are equivocal. Corpus callosum affection in MS patients is intimately related to clinical status and its assessment should be done whenever possible.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s43055-019-0031-x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2090-4762 |
| ispartof | Egyptian Journal of Radiology and Nuclear Medicine, 2019-09, Vol.50 (1), p.30-10, Article 30 |
| issn | 2090-4762 0378-603X 2090-4762 |
| language | eng |
| recordid | cdi_proquest_journals_2812337871 |
| source | Springer Nature - Complete Springer Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Anisotropy Apparent diffusion coefficient Diagnostic imaging Diffusion tensor magnetic resonance imaging Disease Fractional anisotropy Imaging Laboratories Magnetic resonance imaging Medicine Medicine & Public Health Multiple sclerosis Nervous system Normally appearing white matter Nuclear Medicine Patients Radiology Spinal cord Tractography |
| title | Diffusion tensor imaging for assessment of normally appearing white matter of the brain and spinal cord in cases of multiple sclerosis: a multi-parametric correlation in view of patient’s clinical status |
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